Population Dynamics of a Naturally Occurring Heterogeneous Mixture of Borrelia burgdorferiClones
Hofmeister E, Glass G, Childs J, Persing D. Population Dynamics of a Naturally Occurring Heterogeneous Mixture of Borrelia burgdorferiClones. Infection And Immunity 1999, 67: 5709-5716. PMID: 10531219, PMCID: PMC96945, DOI: 10.1128/iai.67.11.5709-5716.1999.Peer-Reviewed Original ResearchConceptsC3H/HeJ miceC.B-17 miceLarval Ixodes scapularis ticksMajority of miceB. burgdorferiInfected nymphal ticksIxodes scapularis ticksBurgdorferi antibodiesSecondary challengeHeJ micePrimary isolatesSequential isolatesC3H miceSequential infectionMiceMonoclonal antibodiesBorrelia burgdorferiC expressionScapularis ticksClonal dominanceUnique isolatesMacrorestriction analysisOspC proteinsClonal groupsEnzootic siteEXPERIMENTAL INFECTION OF COTTON RATS WITH THREE NATURALLY OCCURRING BARTONELLA SPECIES
Kosoy M, Regnery R, Kosaya O, Childs J. EXPERIMENTAL INFECTION OF COTTON RATS WITH THREE NATURALLY OCCURRING BARTONELLA SPECIES. Journal Of Wildlife Diseases 1999, 35: 275-284. PMID: 10231754, DOI: 10.7589/0090-3558-35.2.275.Peer-Reviewed Original ResearchConceptsCotton ratsHigh dosesLow dosesBartonella sppHigh IgG titersHumoral immune responseHigh antibody titersGroups of ratsKinetics of infectionChallenge antigenIgG titersAntibody titersDetectable bacteremiaSecondary challengeImmune responseLow doseHigh doseHigher bacteremiaBacteremiaExperimental infectionSame rodent speciesRatsEvidence of resistanceInactivated bacteriaPeak bacteremia