2002
The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study.
Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ. The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study. Cancer Research 2002, 62: 1045-9. PMID: 11861380.Peer-Reviewed Original ResearchConceptsFirst-degree family historyBreast cancer riskHealth Study cohortAndrogen receptorBreast cancerCancer riskFamily historyAR genotypeCaucasian womenHormone levelsHealth StudyNurses' Health Study cohortBreast cancer risk factorsEndogenous steroid hormone levelsNurses' Health StudyCancer risk factorsPostmenopausal Caucasian womenCase-control studyAndrogen receptor genotypeAndrogen receptor CAGAndrogen receptor allelesSteroid hormone levelsShort alleleLong alleleSignificant positive association
2000
Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women.
Holmes M, Spiegelman D, Willett W, Manson J, Hunter D, Barbieri R, Colditz G, Hankinson S. Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women. Journal Of Clinical Oncology 2000, 18: 3668-76. PMID: 11054440, DOI: 10.1200/jco.2000.18.21.3668.Peer-Reviewed Original ResearchConceptsDietary fat intakeFat intakePostmenopausal womenInverse associationHormone levelsSex steroid hormone levelsHealthy postmenopausal womenTotal fat intakeFood frequency questionnaireEndogenous estrogen levelsBreast cancer riskOmega-3 fatsSex steroid hormonesCross-sectional associationsSteroid hormone levelsPercentage of energyEstradiol levelsEstrogen levelsPlasma sex steroidsPlasma levelsSex steroidsCancer riskProtein intakeEnergy intakeSteroid hormonesA prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk.
Hines LM, Hankinson SE, Smith-Warner SA, Spiegelman D, Kelsey KT, Colditz GA, Willett WC, Hunter DJ. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 2000, 9: 1099-105. PMID: 11045794.Peer-Reviewed Original ResearchConceptsBreast cancer riskAlcohol dehydrogenase type 3Hormone levelsCancer riskSteroid hormone levelsAlcohol intakeAlcohol consumptionADH3 genotypeHealth StudyADH3 polymorphismIncident breast cancer casesSex hormone-binding globulinOverall breast cancer riskPlasma steroid hormone levelsNurses' Health StudyHormone-binding globulinPartial Pearson correlation coefficientsCase-control studyConditional logistic regressionBreast cancer casesPostmenopausal womenProspective studyDehydroepiandrosterone sulfateRelative riskBreast cancer
1999
The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer.
Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer. Cancer Research 1999, 59: 1015-20. PMID: 10070957.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskBreast cancerHormone levelsA2 alleleCancer riskNurses' Health Study cohortStrong independent risk factorA2/A2 genotypeCYP17 A2 alleleElevated levelsAdvanced breast cancerIncident breast cancerIndependent risk factorPolycystic ovarian syndromeCertain steroid hormonesA1/A1 genotypeCase-control studyPlasma hormone levelsSteroid hormone levelsLater agePremenopausal womenCYP17 genotypeHormone replacementOvarian syndrome
1998
Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Hankinson S, Willett W, Manson J, Colditz G, Hunter D, Spiegelman D, Barbieri R, Speizer F. Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 1998, 90: 1292-1299. PMID: 9731736, DOI: 10.1093/jnci/90.17.1292.Peer-Reviewed Original ResearchConceptsSex steroid hormone levelsHormone replacement therapyBreast cancer riskPostmenopausal womenBreast cancerSteroid hormone levelsBlood collectionEstrogen levelsReplacement therapyHormone levelsCancer riskHealth StudyPrevious hormone replacement therapyPlasma sex steroid hormone levelsPostmenopausal estrogen levelsNurses' Health StudyPlasma estrogen levelsLevels of estradiolCase-control studyPlasma androgen levelsBioavailable estradiolMenopausal statusSignificant positive associationControl subjectsLowest quartile