2019
Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana.
Orr AR, Quagraine JE, Suwondo P, George S, Harrison LM, Dornas FP, Evans B, Caccone A, Humphries D, Wilson MD, Cappello M. Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana. American Journal Of Tropical Medicine And Hygiene 2019, 100: 351-356. PMID: 30734697, PMCID: PMC6367626, DOI: 10.4269/ajtmh.18-0727.Peer-Reviewed Original ResearchConceptsMass drug administrationSoil-transmitted helminthsKintampo North MunicipalitySchool-aged childrenSingle nucleotide polymorphismsPolymerase chain reactionEffectiveness of MDAWild-type SNPsInfected study subjectsPeriodic mass drug administrationResistance-associated single nucleotide polymorphismsCross-sectional studyResistance-associated mutationsWorld Health OrganizationHookworm infectionDrug exposureHookworm eggsUnreported associationStudy subjectsDrug AdministrationPosttreatment samplesChemotherapeutic approachesGrowth delayHuman hookwormHealth Organization
2018
Albendazole Treatment Improves Work Capacity in Women Smallholder Farmers Infected with Hookworm: A Double-Blind Randomized Control Trial.
Salmon M, Salmon C, Masoda M, Salumu JM, Bozzi C, Nieburg P, Harrison LM, Humphries D, Abaca Uvon N, Wendel SK, Trout C, Cappello M. Albendazole Treatment Improves Work Capacity in Women Smallholder Farmers Infected with Hookworm: A Double-Blind Randomized Control Trial. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1419-1426. PMID: 29611504, PMCID: PMC5953358, DOI: 10.4269/ajtmh.17-0403.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlbendazoleAnthelminticsDouble-Blind MethodFarmersFemaleHeart RateHookworm InfectionsHumansConceptsWork capacityRandomized Effectiveness TrialSoil-transmitted helminthsHealth of womenStep testPlacebo groupAlbendazole treatmentPrimary outcomeHookworm infectionStep test resultsEffectiveness trialNonsignificant decreaseHeart rateControl trialTreatment groupsIntestinal parasitesPulse rateHookwormTrialsRisk benefitDrug distributionWomenTreatmentAlbendazoleMinutes
2016
Effectiveness of Albendazole for Hookworm Varies Widely by Community and Correlates with Nutritional Factors: A Cross-Sectional Study of School-Age Children in Ghana.
Humphries D, Nguyen S, Kumar S, Quagraine JE, Otchere J, Harrison LM, Wilson M, Cappello M. Effectiveness of Albendazole for Hookworm Varies Widely by Community and Correlates with Nutritional Factors: A Cross-Sectional Study of School-Age Children in Ghana. American Journal Of Tropical Medicine And Hygiene 2016, 96: 347-354. PMID: 27895280, PMCID: PMC5303035, DOI: 10.4269/ajtmh.16-0682.Peer-Reviewed Original ResearchConceptsEgg reduction rateCross-sectional studyMass drug administrationSchool-aged childrenEffectiveness of albendazoleCure rateDrug AdministrationMid-upper arm circumferenceSoil-transmitted helminth infectionsHost factorsNutritional factorsSingle-dose albendazoleOverall cure rateBlood hemoglobin levelsKintampo North MunicipalitySignificant community-level variationIndividual host factorsWorld Health OrganizationCommon STHHemoglobin levelsArm circumferenceHookworm infectionHelminth infectionsDeworming programsHookworm prevalence
2013
In vitro Screening of Compounds against Laboratory and Field Isolates of Human Hookworm Reveals Quantitative Differences in Anthelmintic Susceptibility
Treger RS, Otchere J, Keil MF, Quagraine JE, Rai G, Mott BT, Humphries DL, Wilson M, Cappello M, Vermeire JJ. In vitro Screening of Compounds against Laboratory and Field Isolates of Human Hookworm Reveals Quantitative Differences in Anthelmintic Susceptibility. American Journal Of Tropical Medicine And Hygiene 2013, 90: 71-74. PMID: 24297811, PMCID: PMC3886431, DOI: 10.4269/ajtmh.12-0547.Peer-Reviewed Original ResearchConceptsField isolatesA. ceylanicumHookwormScreening of compoundsAncylostoma ceylanicumHuman hookwormAnthelmintic compoundsLaboratory strainsHookworm speciesPercent inhibitionSchool childrenTwofold increaseSelect compoundsAnthelmintic activityNovel anthelmintic compoundsAnthelmintic susceptibilityBrong Ahafo RegionIsolatesAhafo Region
2012
The promise and pitfalls of mass drug administration to control intestinal helminth infections
Humphries D, Nguyen S, Boakye D, Wilson M, Cappello M. The promise and pitfalls of mass drug administration to control intestinal helminth infections. Current Opinion In Infectious Diseases 2012, 25: 584-589. PMID: 22903231, DOI: 10.1097/qco.0b013e328357e4cf.Peer-Reviewed Original ResearchMeSH KeywordsAnthelminticsCost of IllnessGlobal HealthHelminthiasisHumansIntestinal DiseasesIntestinal Diseases, ParasiticConceptsMass drug administrationIntestinal helminth infectionsHelminth infectionsDrug AdministrationSoil-transmitted nematode infectionsIntensity of schistosomiasisHigh-risk groupResource-limited settingsLong-term controlSignificant morbidityPregnant womenLong-term benefitsNew drug developmentIntensity of infectionIntestinal helminthsEndemic areasConsistent benefitInfectionChemotherapeutic interventionCertain populationsDrug developmentBenzimidazole anthelminthicsIntensive monitoringPrevalenceAdministration
2011
Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure
Humphries D, Mosites E, Otchere J, Twum WA, Woo L, Jones-Sanpei H, Harrison LM, Bungiro RD, Benham-Pyle B, Bimi L, Edoh D, Bosompem K, Wilson M, Cappello M. Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure. American Journal Of Tropical Medicine And Hygiene 2011, 84: 792-800. PMID: 21540391, PMCID: PMC3083749, DOI: 10.4269/ajtmh.2011.11-0003.Peer-Reviewed Original ResearchConceptsPoor nutritional statusHookworm infectionRisk factorsNutritional statusOverall egg reduction rateSerum immunoglobulin G (IgG) reactivitiesCross-sectional pilot studyEgg reduction rateImmunoglobulin G reactivityKintampo North MunicipalityAlbendazole therapyKintampo NorthMalaria coinfectionTreatment failureOverall prevalenceHigh prevalenceRepeat examinationEgg excretionSecretory antigensInfectionPilot studyCoinfectionSignificant reductionTherapyHigh rate