2019
Multivariate spatiotemporal modeling of drug- and alcohol-poisoning deaths in New York City, 2009–2014
Ransome Y, Subramanian SV, Duncan DT, Vlahov D, Warren J. Multivariate spatiotemporal modeling of drug- and alcohol-poisoning deaths in New York City, 2009–2014. Spatial And Spatio-temporal Epidemiology 2019, 32: 100306. PMID: 32007280, PMCID: PMC9996640, DOI: 10.1016/j.sste.2019.100306.Peer-Reviewed Original ResearchConceptsDrug-poisoning deathsMultivariate Poisson regression modelCurrent public health problemPublic health problemZip codesDrug overdose deathsCo-occurring epidemicsPublic health plannersPoisson regression modelsHigh prevalenceOverdose deathsHealth problemsHealth plannersHeavy drinkingDeathDrugsOutcomesRegression modelsPredictorsNew York CityIndividual-level predictorsPrevalenceYork City
2013
Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population
Manini A, Jacobs M, Vlahov D, Hurd Y. Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population. Journal Of Medical Toxicology 2013, 9: 148-154. PMID: 23318993, PMCID: PMC3648633, DOI: 10.1007/s13181-012-0286-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternative SplicingAmino Acid SubstitutionBenzodiazepinesCohort StudiesDrug OverdoseFemaleFollow-Up StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHeart ArrestHumansMaleNarcoticsPilot ProjectsPolymorphism, Single NucleotideProspective StudiesReceptors, Opioid, muRespiratory InsufficiencySeverity of Illness IndexSympathomimeticsUnited StatesConceptsAcute drug overdoseG variant alleleClinical severityVariant allelesEmergency departmentDrug overdoseSingle nucleotide polymorphismsConsecutive adult ED patientsHuman mu-opioid receptor geneReceptor single nucleotide polymorphismsWorse clinical severityAdult ED patientsObservational cohort studyUrban teaching hospitalMu-opioid receptor geneAbove single nucleotide polymorphismsCohort studyED patientsRespiratory arrestCardiac arrestClinical variablesAcute drugSevere outcomesTeaching hospitalBlood samples
2008
Prevalence and Correlates of Previous Hepatitis B Vaccination and Infection Among Young Drug-users In New York City
Amesty S, Ompad D, Galea S, Fuller C, Wu Y, Koblin B, Vlahov D. Prevalence and Correlates of Previous Hepatitis B Vaccination and Infection Among Young Drug-users In New York City. Journal Of Community Health 2008, 33: 139-148. PMID: 18185987, DOI: 10.1007/s10900-007-9082-4.Peer-Reviewed Original ResearchConceptsEvidence of infectionHBV vaccinationPrevious vaccinationSerological evidenceHepatitis B vaccination coveragePrevious hepatitis B vaccinationPrevious HBV infectionPrevious HBV vaccinationHepatitis B vaccinationHepatitis B vaccineHigh-risk groupYears of ageCommunity-based sampleB vaccinationHBV infectionB vaccineVaccination statusVaccination coverageRisk groupsHigh school educationVaccinationSusceptible individualsDrug usersInfection rateBivariate analysis
2007
Explaining Racial Disparities in Incidence of and Survival from Out-of-Hospital Cardiac Arrest
Galea S, Blaney S, Nandi A, Silverman R, Vlahov D, Foltin G, Kusick M, Tunik M, Richmond N. Explaining Racial Disparities in Incidence of and Survival from Out-of-Hospital Cardiac Arrest. American Journal Of Epidemiology 2007, 166: 534-543. PMID: 17584756, DOI: 10.1093/aje/kwm102.Peer-Reviewed Original ResearchConceptsAge-adjusted survivalInitial cardiac rhythmHospital cardiac arrestCardiac arrestCardiac rhythmAge-adjusted relative oddsEthnic disparitiesPrior functional statusProspective observational studyAge-adjusted incidenceEmergency medical services responseLikelihood of receiptFull multivariable modelOOHCA patientsHospital dischargeConsecutive casesFunctional statusCardiopulmonary resuscitationMultivariable modelObservational studyVentricular fibrillationLow prevalenceRelative oddsOOHCARacial disparitiesIdentifying injection drug users at risk of nonfatal overdose.
Coffin P, Tracy M, Bucciarelli A, Ompad D, Vlahov D, Galea S. Identifying injection drug users at risk of nonfatal overdose. Academic Emergency Medicine 2007, 14: 616-23. PMID: 17554010, DOI: 10.1197/j.aem.2007.04.005.Peer-Reviewed Original ResearchConceptsDrug usersHabitual drug usersNonfatal overdoseAggressive prevention effortsAgonist maintenance treatmentSerious withdrawal symptomsInjection drug usersFurther longitudinal studiesIndividual-level risk factorsTake-home naloxoneOverdose prevention interventionsFuture overdosesMaintenance treatmentWithdrawal symptomsRisk factorsDrug overdoseRecent overdoseEmergency physiciansOverdose riskPrevention interventionsHigh riskOverdoseMedical careYounger ageU.S. adultsEarly immunologic and virologic responses to highly active antiretroviral therapy and subsequent disease progression among HIV-infected injection drug users
Mehta S, Lucas G, Astemborski J, Kirk G, Vlahov D, Galai N. Early immunologic and virologic responses to highly active antiretroviral therapy and subsequent disease progression among HIV-infected injection drug users. AIDS Care 2007, 19: 637-645. PMID: 17505924, DOI: 10.1080/09540120701235644.Peer-Reviewed Original ResearchConceptsInjection drug usersActive antiretroviral therapyRisk of progressionVirologic responseTreatment interruptionImmunologic responseAntiretroviral therapyCommunity-based injection drug usersDrug usersMultiple Cox regression analysisRecent outpatient visitYears of HAARTCox regression analysisInjection drug useNew AIDS diagnosesSubsequent disease progressionEarly responseHAART initiationHAART initiatorsHIV careOutpatient visitsCox regressionPrognostic valueAIDS diagnosisPoor response
2006
Physical activity in a cohort of HIV-positive and HIV-negative injection drug users
Smit E, Crespo C, Semba R, Jaworowicz D, Vlahov D, Ricketts E, Ramirez-Marrero F, Tang A. Physical activity in a cohort of HIV-positive and HIV-negative injection drug users. AIDS Care 2006, 18: 1040-1045. PMID: 17012097, DOI: 10.1080/09540120600580926.Peer-Reviewed Original ResearchConceptsInjection drug usersHIV-positive participantsHIV-positive injection drug usersInjection drug useHIV-negativeVigorous activityPhysical activityDrug usersDrug usePaffenbarger Physical Activity QuestionnaireRecent injection drug usersHIV-negative injection drug usersIntravenous Experience cohortActive antiretroviral therapyCohort of HIVHIV-negative participantsPhysical Activity QuestionnairePhysical activity levelsAntiretroviral therapyHIV infectionViral loadHIV treatmentActivity QuestionnaireAnthropometric measurementsEnergy expenditureDeterminants of influenza vaccination in hard-to-reach urban populations
Bryant W, Ompad D, Sisco S, Blaney S, Glidden K, Phillips E, Vlahov D, Galea S, Group F. Determinants of influenza vaccination in hard-to-reach urban populations. Preventive Medicine 2006, 43: 60-70. PMID: 16684559, DOI: 10.1016/j.ypmed.2006.03.018.Peer-Reviewed Original ResearchConceptsInfluenza vaccinationRoutine medical careMedical careReceipt of healthInfluenza vaccination ratesCross-sectional studyVenue-based samplingGovernment health insuranceTime of surveyLow annual incomeVaccination ratesMultivariable modelVaccinationMinority raceHealth insuranceEast HarlemDisadvantaged urban areasReach populationsCareTotal respondentsSocial servicesParticipantsNew York CityHealthPrevious year
2005
Probable Cigarette Dependence, PTSD, and Depression after an Urban Disaster: Results from a Population Survey of New York City Residents 4 Months after September 11, 2001
Arijit N, Sandro G, Jennifer A, Vlahov D. Probable Cigarette Dependence, PTSD, and Depression after an Urban Disaster: Results from a Population Survey of New York City Residents 4 Months after September 11, 2001. Psychiatry 2005, 68: 299-310. PMID: 16599397, DOI: 10.1521/psyc.2005.68.4.299.Peer-Reviewed Original ResearchConceptsProbable posttraumatic stress disorderProbable PTSDCigarette dependenceCigarette useDSM-IV criteriaSubstance-related disordersRandom digit dialingPosttraumatic stress disorderCigarette smokingProbable depressionMore symptomsDrug useStress disorderDepressionDisaster exposureNational surveySymptomsMonthsPopulation surveyDisordersRepresentative sampleNew York CitySmokersSmokingCasesInjection Drug Use Is an Independent Risk Factor for Iron Deficiency and Iron Deficiency Anemia Among HIV-Seropositive and HIV-Seronegative Women
Dancheck B, Tang A, Thomas A, Smit E, Vlahov D, Semba R. Injection Drug Use Is an Independent Risk Factor for Iron Deficiency and Iron Deficiency Anemia Among HIV-Seropositive and HIV-Seronegative Women. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 198-201. PMID: 16186738, DOI: 10.1097/01.qai.0000165909.12333.07.Peer-Reviewed Original ResearchConceptsInjection drug useIron deficiency anemiaHepatitis C virus statusFemale injection drug usersC virus statusInjection drug usersDeficiency anemiaDrug useIron deficiencyRisk factorsVirus statusDrug usersMultivariate analysisInjection drug use historyCD4 lymphocyte countHIV-seronegative womenIndependent risk factorHIV-positive womenCross-sectional studyFurther longitudinal studiesNatural history studiesIntravenous Experience (ALIVE) studyDrug use historyHIV-seropositiveLymphocyte countHaplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study
Modi W, Scott K, Goedert J, Vlahov D, Buchbinder S, Detels R, Donfield S, O'Brien S, Winkler C. Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. Genes & Immunity 2005, 6: 691-698. PMID: 16177829, DOI: 10.1038/sj.gene.6364258.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAllelesBlack or African AmericanChemokine CXCL12Chemokines, CXCChildCohort StudiesDisease ProgressionFemaleGene FrequencyHaplotypesHIV InfectionsHIV-1HumansLongitudinal StudiesMaleOdds RatioPolymorphism, Single NucleotideRisk FactorsSurvival AnalysisUnited StatesWhite PeopleConceptsSDF-1 geneCohort studySingle nucleotide polymorphismsAfrican AmericansOnly natural ligandSingle disease outcomesX4 HIV-1HIV-1 infectionAIDS Cohort StudyRisk of infectionMACS cohortDisease outcomeHIV-1Epidemiological studiesSDF-1Significant associationChemokine genesInfectionRs1801157Natural ligandProgressionHaplotype analysisCommon haplotypeCXCR4CohortUrban built environment and depression: a multilevel analysis
Galea S, Ahern J, Rudenstine S, Wallace Z, Vlahov D. Urban built environment and depression: a multilevel analysis. Journal Of Epidemiology & Community Health 2005, 59: 822. PMID: 16166352, PMCID: PMC1732922, DOI: 10.1136/jech.2005.033084.Peer-Reviewed Original ResearchConceptsNew York CityNew York City HousingUrban planning effortsFuture prospective workNeighborhood-level incomeCity housingVacancy SurveyNeighborhood of residencePlanning effortsNeighborhoodNYC neighborhoodsLifetime depressionYork CityPoor featuresLevel incomeManagement reportsEnvironmentPopulation mental healthResidencePoor qualityCross-sectional surveyHousingRace/ethnicityProspective workCityLiver enzyme values in injection drug users with chronic hepatitis C
Mehta S, Netski D, Sulkowski M, Strathdee S, Vlahov D, Thomas D. Liver enzyme values in injection drug users with chronic hepatitis C. Digestive And Liver Disease 2005, 37: 674-680. PMID: 15951255, DOI: 10.1016/j.dld.2005.03.009.Peer-Reviewed Original ResearchConceptsHepatitis C virusHepatitis C virus-infected personsAcute viral hepatitisLiver enzyme valuesVirus-infected personsC virusAminotransferase levelsViral hepatitisAlanine aminotransferaseAlanine aminotransferase/aspartate aminotransferase ratioChronic hepatitis C virus (HCV) infectionEnzyme valuesHepatitis C virus infectionAspartate aminotransferase ratioC virus infectionChronic hepatitis CHigher alanine aminotransferaseInjection drug usersHepatitis CAminotransferase ratioSerologic testingLiver enzymesULNVirus infectionDrug usersCommunity Incidence of Hepatitis B and C among Reincarcerated Women
Macalino G, Vlahov D, Dickinson B, Schwartzapfel B, Rich J. Community Incidence of Hepatitis B and C among Reincarcerated Women. Clinical Infectious Diseases 2005, 41: 998-1002. PMID: 16142665, DOI: 10.1086/432936.Peer-Reviewed Original ResearchConceptsHepatitis B virusIncidence of HBVHCV infectionHepatitis BHepatitis C virus infectionC virus infectionDrug treatment servicesDrug-dependent personsIncident infectionsHIV testingBaseline prevalenceB virusCommunity incidenceIncidence rateVirus infectionTreatment servicesDrug useDrug dependenceInfectious diseasesInfectionSerum samplesIncidenceStudy periodWomenHCVSexual Risk Behavior Among Injection Drug Users Before Widespread Availability of Highly Active Antiretroviral Therapy
Rusch M, Farzadegan H, Tarwater P, Safaeian M, Vlahov D, Strathdee S. Sexual Risk Behavior Among Injection Drug Users Before Widespread Availability of Highly Active Antiretroviral Therapy. AIDS And Behavior 2005, 9: 289-299. PMID: 16133905, DOI: 10.1007/s10461-005-9003-4.Peer-Reviewed Original ResearchConceptsInjection drug usersCondom useAntiretroviral therapyHIV testingDrug usersEligible injection drug usersRisk behaviorsActive antiretroviral therapyInconsistent condom useSexual risk behaviorsIDU cohortHIV transmissionRetrospective analysisLower riskStudy exposureSexual riskLong-term studiesTherapySignificant changesCounselingRiskExposureLogistic modelWidespread availabilityCohortThe relationship between non‐injection drug use behaviors on progression to AIDS and death in a cohort of HIV seropositive women in the era of highly active antiretroviral therapy use
Kapadia F, Cook J, Cohen M, Sohler N, Kovacs A, Greenblatt R, Choudhary I, Vlahov D. The relationship between non‐injection drug use behaviors on progression to AIDS and death in a cohort of HIV seropositive women in the era of highly active antiretroviral therapy use. Addiction 2005, 100: 990-1002. PMID: 15955015, PMCID: PMC3128378, DOI: 10.1111/j.1360-0443.2005.01098.x.Peer-Reviewed Original ResearchConceptsNon-injection drug useWomen's Interagency HIV StudyHIV progressionMultivariate analysisActive antiretroviral therapy (HAART) eraActive antiretroviral therapy (HAART) useMultivariate Cox proportional hazardsAntiretroviral therapy eraAntiretroviral therapy useFormer usersHIV-seropositive womenProspective cohort studyCells/Cox proportional hazardsDrug use behaviorsUse of stimulantsCause deathHAART initiationHAART utilizationTherapy eraCause mortalityHAART useSeropositive womenAIDS eventsCohort studyThe urban built environment and overdose mortality in New York City neighborhoods
Hembree C, Galea S, Ahern J, Tracy M, Piper T, Miller J, Vlahov D, Tardiff K. The urban built environment and overdose mortality in New York City neighborhoods. Health & Place 2005, 11: 147-156. PMID: 15629682, DOI: 10.1016/j.healthplace.2004.02.005.Peer-Reviewed Original ResearchConceptsAccidental drug overdoseNew York City HousingMultilevel case-control studyNew York City OfficeNew York City neighborhoodsAccidental overdose deathsFatal drug overdoseCharacteristics of neighborhoodsCity housingDrug overdose mortalityCity neighborhoodsVacancy SurveyMayor's OfficeDifferent neighborhoodsCity OfficeNeighborhood-level variablesNeighborhoodInternal environmentNeighborhood differencesExternal environmentOfficeEnvironmentHousingDisinvestmentSocial resourcesEcstasy Use Among Hispanic and Black Substance Users in New York City
Ompad D, Galea S, Fuller C, Edwards V, Vlahov D. Ecstasy Use Among Hispanic and Black Substance Users in New York City. Substance Use & Misuse 2005, 40: 1399-1407. PMID: 16048824, DOI: 10.1081/ja-200066960.Peer-Reviewed Original ResearchSuicidal ideation among African-American non-injection drug users.
Havens J, Ompad D, Latkin C, Fuller C, Arria A, Vlahov D, Strathdee S. Suicidal ideation among African-American non-injection drug users. Ethnicity & Disease 2005, 15: 110-5. PMID: 15720057.Peer-Reviewed Original ResearchConceptsSuicidal ideationDrug usersDrug dependenceNon-injection drug usersCommunity-based cohortInterview-administered questionnaireMultiple logistic regressionDrug use historyUse of heroinAfrican American drug usersMedian agePsychiatric comorbidityDepressive symptomsMore drugsSuicidal thoughtsLogistic regressionIdeationAfrican AmericansUse historyParticipantsComorbiditiesCohortSymptomsYearsHeroin
2004
Acceptance and completion of hepatitis B vaccination among drug users in New York City.
Ompad D, Galea S, Wu Y, Fuller C, Latka M, Koblin B, Vlahov D. Acceptance and completion of hepatitis B vaccination among drug users in New York City. Communicable Disease And Public Health 2004, 7: 294-300. PMID: 15779793.Peer-Reviewed Original ResearchConceptsDrug usersVaccine acceptanceHepatitis B vaccination ratesNon-injecting drug usersDaily crack usersPrevious HBV infectionHepatitis B vaccinationB vaccination ratesOngoing prospective studyB vaccinationDaily injectorsHBV testingHBV vaccinationVaccination seriesVaccine acceptorsHBV infectionVaccine seriesPrevious vaccinationRisk behavior questionnaireProspective studyVaccination acceptanceVaccination ratesSerological evidenceSeries completionVaccination