Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells
Markham R, Schwartz D, Templeton A, Margolick J, Farzadegan H, Vlahov D, Yu X. Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells. Journal Of Virology 1996, 70: 6947-6954. PMID: 8794338, PMCID: PMC190744, DOI: 10.1128/jvi.70.10.6947-6954.1996.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 variantsHu-PBLSCID miceType 1 variantsPrimary isolatesNSI variantsSCID mouse model systemPeripheral blood mononuclear cellsBlood mononuclear cellsHIV-1 variantsMT-2 cellsMouse model systemMononuclear cellsRelative infectiousnessCell culturesVaccine developmentClinical settingMiceEnv sequencesMonoclonal cellsTissue culture systemCellsIsolatesCulture systemPreferential transmissionEvidence for HIV Type 1 Strains of U.S. Intravenous Drug Users as Founders of AIDS Epidemic among Intravenous Drug Users in Northern Europe
Lukashov V, Kuiken C, Vlahov D, Coutinho R, Goudsmit J. Evidence for HIV Type 1 Strains of U.S. Intravenous Drug Users as Founders of AIDS Epidemic among Intravenous Drug Users in Northern Europe. AIDS Research And Human Retroviruses 1996, 12: 1179-1183. PMID: 8844022, DOI: 10.1089/aid.1996.12.1179.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHomosexual menDrug usersV3 sequencesEuropean intravenous drug usersHIV Type 1 StrainsAIDS epidemicHIV-1 epidemicGp120 V3 loopSignature pattern analysisType 1 strainsRisk groupsV3 loopEpidemiological linkMenEpidemicVirusUnited StatesSuggestive evidencePresent suggestive evidenceHigh levelsNucleotide substitutionsEuropean origin