2005
Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study
Modi W, Scott K, Goedert J, Vlahov D, Buchbinder S, Detels R, Donfield S, O'Brien S, Winkler C. Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. Genes & Immunity 2005, 6: 691-698. PMID: 16177829, DOI: 10.1038/sj.gene.6364258.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAllelesBlack or African AmericanChemokine CXCL12Chemokines, CXCChildCohort StudiesDisease ProgressionFemaleGene FrequencyHaplotypesHIV InfectionsHIV-1HumansLongitudinal StudiesMaleOdds RatioPolymorphism, Single NucleotideRisk FactorsSurvival AnalysisUnited StatesWhite PeopleConceptsSDF-1 geneCohort studySingle nucleotide polymorphismsAfrican AmericansOnly natural ligandSingle disease outcomesX4 HIV-1HIV-1 infectionAIDS Cohort StudyRisk of infectionMACS cohortDisease outcomeHIV-1Epidemiological studiesSDF-1Significant associationChemokine genesInfectionRs1801157Natural ligandProgressionHaplotype analysisCommon haplotypeCXCR4Cohort
2003
Longitudinal Patterns of Drug Injection Behavior in the ALIVE Study Cohort,1988–2000: Description and Determinants
Galai N, Safaeian M, Vlahov D, Bolotin A, Celentano D. Longitudinal Patterns of Drug Injection Behavior in the ALIVE Study Cohort,1988–2000: Description and Determinants. American Journal Of Epidemiology 2003, 158: 695-704. PMID: 14507606, DOI: 10.1093/aje/kwg209.Peer-Reviewed Original ResearchConceptsInjection drug usersDrug injection behaviorDrug usersIntravenous Experience (ALIVE) studyDrug treatment programsHistory of incarcerationLogistic regression modelsALIVE studySemiannual visitsMultinomial logistic regression modelsBaseline factorsChronic diseasesDrug injectionRecent overdoseCessation attemptsDrug use transitionsDrug injectorsCommunity outreach effortsLongitudinal patternsHigh mortalityEarly determinantsYounger ageTreatment programInjection behaviorStudy periodSocial Circumstances of Initiation of Injection Drug Use and Early Shooting Gallery Attendance: Implications for HIV Intervention Among Adolescent and Young Adult Injection Drug Users
Fuller C, Vlahov D, Latkin C, Ompad D, Celentano D, Strathdee S. Social Circumstances of Initiation of Injection Drug Use and Early Shooting Gallery Attendance: Implications for HIV Intervention Among Adolescent and Young Adult Injection Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 32: 86. PMID: 12514419, DOI: 10.1097/00126334-200301010-00013.Peer-Reviewed Original ResearchConceptsInjection drug usersNew injection drug usersOlder injection drug usersYoung adult injection drug usersDrug usersHigh-risk injection drug usersStreet-recruited injection drug usersAdult injection drug usersYoung injection drug usersGallery attendanceProspective cohort studyInjection drug useMultiple logistic regressionHigh-risk practicesCohort studyMedian ageHIV incidenceHIV prevalenceInnovative intervention strategiesHIV interventionsDrug useLogistic regressionHIVBaseline dataMost participants
2002
Does Bleach Disinfection of Syringes Protect Against Hepatitis C Infection Among Young Adult Injection Drug Users?
Kapadia F, Vlahov D, Jarlais D, Strathdee S, Ouellet L, Kerndt P, E E, Williams I, Garfein R. Does Bleach Disinfection of Syringes Protect Against Hepatitis C Infection Among Young Adult Injection Drug Users? Epidemiology 2002, 13: 738-741. PMID: 12410020, DOI: 10.1097/00001648-200211000-00023.Peer-Reviewed Original ResearchConceptsInjection drug usersAnti-HCV seroconversionHepatitis C virusDrug usersOdds ratioBleach useYoung adult injection drug usersSeronegative injection drug usersMajor public health problemAdult injection drug usersBleach disinfectionHepatitis C infectionProspective cohort studyCase-control studyConditional logistic regressionPublic health problemCessation of injectionsC infectionHCV infectionCohort studyC virusProtective effectHealth problemsSeroconversionLogistic regressionHLA-Cw*04 and Hepatitis C Virus Persistence
Thio C, Gao X, Goedert J, Vlahov D, Nelson K, Hilgartner M, O'Brien S, Karacki P, Astemborski J, Carrington M, Thomas D. HLA-Cw*04 and Hepatitis C Virus Persistence. Journal Of Virology 2002, 76: 4792-4797. PMID: 11967296, PMCID: PMC136132, DOI: 10.1128/jvi.76.10.4792-4797.2002.Peer-Reviewed Original ResearchConceptsHuman leukocyte antigenHCV infectionViral persistenceAcute hepatitis C virus (HCV) infectionAssociation of HLAHepatitis C virus infectionHepatitis C virus (HCV) persistenceKiller immunoglobulin-like receptorsClass I human leukocyte antigenEarly host immune responseC virus infectionHCV RNA levelsNatural killer cellsImmunoglobulin-like receptorsCytolytic T cellsHost immune responsePolymorphic HLA genesHCV clearanceHCV persistenceKiller cellsViral clearanceLeukocyte antigenPx groupForeign antigensT cellsHigh-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study
Fuller C, Vlahov D, Ompad D, Shah N, Arria A, Strathdee S. High-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study. Drug And Alcohol Dependence 2002, 66: 189-198. PMID: 11906806, DOI: 10.1016/s0376-8716(01)00200-9.Peer-Reviewed Original ResearchConceptsInjection drug usersInjection drug useAge-matched case-control analysisDrug usersDrug useBlood-borne infectionsAge-matched personsCase-control studyConditional logistic regressionCase-control analysisHigh-risk behaviorsNon-injection heroinCharacteristics of personsHIV seroprevalenceCohort studyInjection useAdult drug usersLogistic regressionPrevention effortsSame calendar timeYoung adult drug usersCalendar timePrior yearAfrican AmericansBaseline
2001
Multiple Access to Sterile Syringes for Injection Drug Users: Vending Machines, Needle Exchange Programs and Legal Pharmacy Sales in Marseille, France
Moatti J, Vlahov D, Feroni I, Perrin V, Obadia Y. Multiple Access to Sterile Syringes for Injection Drug Users: Vending Machines, Needle Exchange Programs and Legal Pharmacy Sales in Marseille, France. European Addiction Research 2001, 7: 40-45. PMID: 11316925, DOI: 10.1159/000050713.Peer-Reviewed Original ResearchConceptsInjection drug usersNeedle exchange programsSterile syringesNEP usersNew syringesPharmacy salesCharacteristics of IDUsDrug usersPrevention of HIVDrug use characteristicsHIV prevention programsSelf-administered questionnaireMethadone programsHeroin injectorsUseful adjunctPrevention programsInfectious diseasesProgram utilizationHIVSyringesPharmacyExchange programsQuestionnaireBuprenorphineDiseaseSelective risk taking among needle exchange participants: implications for supplemental interventions.
Valente T, Vlahov D. Selective risk taking among needle exchange participants: implications for supplemental interventions. American Journal Of Public Health 2001, 91: 406-11. PMID: 11236405, PMCID: PMC1446573, DOI: 10.2105/ajph.91.3.406.Peer-Reviewed Original ResearchDynamics of behavioral risk factors for HIV/AIDS: a 6-year prospective study of injection drug users
Celentano D, Muñoz A, Cohn S, Vlahov D. Dynamics of behavioral risk factors for HIV/AIDS: a 6-year prospective study of injection drug users. Drug And Alcohol Dependence 2001, 61: 315-322. PMID: 11164696, DOI: 10.1016/s0376-8716(00)00154-x.Peer-Reviewed Original ResearchConceptsBehavioral risk factorsInjection drug usersProspective studyHIV transmissionRisk factorsDrug usersHIV behavioral risk factorsIncremental risk reductionHIV/AIDSRisk reductionHIV-seronegativesTime-dependent covariatesDrug injectorsHigh riskRisk behaviorsBehavioral risksBehavior changeRisky behaviorsRegression modelsLongitudinal predictorsRiskSeronegativesHIVAIDSAbstinenceCharacteristics of injection drug using parents who retain their children
Pilowsky D, Lyles C, Cross S, Celentano D, Nelson K, Vlahov D. Characteristics of injection drug using parents who retain their children. Drug And Alcohol Dependence 2001, 61: 113-122. PMID: 11137275, DOI: 10.1016/s0376-8716(00)00130-7.Peer-Reviewed Original ResearchConceptsInjection drug usersClinical symptomsHIV-positive parentsActive drug useAge 14High-risk practicesHIV statusInjection drugsRetention of childrenDrug usersDrug useAsymptomatic parentsHealth factorsHIVDrug practicesHealth insuranceChildrenPositive parentsCommunity sampleSymptomsRelated behaviorsParentsIllnessFactors associated with prevalent hepatitis C: differences among young adult injection drug users in lower and upper Manhattan, New York City
Diaz T, Des Jarlais D, Vlahov D, Perlis T, Edwards V, Friedman S, Rockwell R, Hoover D, Williams I, Monterroso E. Factors associated with prevalent hepatitis C: differences among young adult injection drug users in lower and upper Manhattan, New York City. American Journal Of Public Health 2001, 91: 23-30. PMID: 11189819, PMCID: PMC1446499, DOI: 10.2105/ajph.91.1.23.Peer-Reviewed Original ResearchConceptsInjection drug usersYoung adult injection drug usersAdult injection drug usersHepatitis B virusDrug usersHCV infectionPrevalent hepatitis C virus infectionHepatitis C virus infectionYoung injection drug usersAnti-HCV positivityPrevalent HCV infectionPrevalent hepatitis CC virus infectionHIV serologyHCV antibodiesHepatitis CB virusVirus infectionDrug treatmentDrug useHCVNew York CitySex practicesInfectionUpper Manhattan
1999
Syringe vending machines for injection drug users: an experiment in Marseille, France.
Obadia Y, Feroni I, Perrin V, Vlahov D, Moatti J. Syringe vending machines for injection drug users: an experiment in Marseille, France. American Journal Of Public Health 1999, 89: 1852-4. PMID: 10589315, PMCID: PMC1509009, DOI: 10.2105/ajph.89.12.1852.Peer-Reviewed Original ResearchSelf-Reported Bacterial Infections Among Women with or at Risk for Human Immunodeficiency Virus Infection
Flanigan T, Hogan J, Smith D, Schoenbaum E, Vlahov D, Schuman P, Mayer K. Self-Reported Bacterial Infections Among Women with or at Risk for Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 1999, 29: 608-612. PMID: 10530455, DOI: 10.1086/598641.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionCD4 cell countImmunodeficiency virus infectionBacterial infectionsRecent pneumoniaVirus infectionCell countHIV-negative womenHIV-seropositive womenUrinary tract infectionInjection drug useLogistic regression analysisSelf-reported pneumoniaCross-sectional analysisSeronegative womenTract infectionsHIV infectionDrug useLifetime historyInfectionPneumoniaMajor causeWomenRegression analysisCell categoriesThe effect of immunodeficiency on cutaneous delayed-type hypersensitivity testing in HIV-infected women without anergy: implications for tuberculin testing. HER Study Group. HIV Epidemiology Research.
Klein R, Flanigan T, Schuman P, Smith D, Vlahov D. The effect of immunodeficiency on cutaneous delayed-type hypersensitivity testing in HIV-infected women without anergy: implications for tuberculin testing. HER Study Group. HIV Epidemiology Research. The International Journal Of Tuberculosis And Lung Disease 1999, 3: 681-8. PMID: 10460100.Peer-Reviewed Original ResearchConceptsCell countSeronegative womenHigh-risk seronegative womenHuman immunodeficiency virus (HIV) infectionDelayed-type hypersensitivity testingDegree of immunodeficiencyHIV antibody testingImmunodeficiency virus infectionType hypersensitivity responseEffects of immunodeficiencyUrban medical centerDTH antigensDTH testingHIV seropositivesHIV-seronegativesPPD sizeSeropositive womenLymphocyte countHIV infectionAntibody testingHypersensitivity responseTuberculin antigenCutaneous responseHypersensitivity testingTetanus toxoid
1998
Satellite exchange in the Baltimore Needle Exchange Program.
Valente T, Foreman R, Junge B, Vlahov D. Satellite exchange in the Baltimore Needle Exchange Program. Public Health Reports 1998, 113 Suppl 1: 90-6. PMID: 9722814, PMCID: PMC1307731.Peer-Reviewed Original ResearchConceptsPrevention messagesBaltimore Needle Exchange ProgramHIV prevention messagesNeedle exchange programsNeedle exchange program participantsDrug-using networksDrug injectorsNumber of syringesDrug usersDrug useRisk behaviorsLogistic regressionOne-way ANOVAIDUsPrevention materialsProgram effectivenessProgram participantsActivities of SSParticipantsPotential bridgeExchange programsGenetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Winkler C, Modi W, Smith M, Nelson G, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert J, O'Brien T, Jacobson L, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, Study A, Study H, Study M, Study M, Cohort S, O'Brien S. Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant. Science 1998, 279: 389-393. PMID: 9430590, DOI: 10.1126/science.279.5349.389.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultChemokine CXCL12ChemokinesChemokines, CXCCohort StudiesDisease ProgressionGenesGenetic VariationGenotypeHeterozygoteHIV InfectionsHIV-1HumansMaleMolecular Sequence DataOdds RatioPolymorphism, GeneticRacial GroupsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CXCR4Survival AnalysisT-LymphocytesConceptsSDF1-3'AGenetic restrictionRecessive protective effectOnset of AIDSAIDS Cohort StudyStromal-derived factorCohort studyImmunodeficiency syndromeAIDS pathogenesisHuman immunodeficiencyHIV-1Protective effectCommon polymorphismsReceptor variantsGene variantsPrincipal ligandAIDSHomozygous stateGenetic association analysisOnsetCD4CCR5PatientsGene transcriptsImmunodeficiency
1997
Postcoital Vaginal Bleeding as a Risk Factor for Transmission of the Human Immunodeficiency Virus in a Heterosexual Partner Study in Brazil
Guimarães M, Vlahov D, Castilho E. Postcoital Vaginal Bleeding as a Risk Factor for Transmission of the Human Immunodeficiency Virus in a Heterosexual Partner Study in Brazil. JAMA Internal Medicine 1997, 157: 1362-1368. PMID: 9201011, DOI: 10.1001/archinte.1997.00440330102012.Peer-Reviewed Original ResearchConceptsPostcoital vaginal bleedingHIV infectionVaginal bleedingRisk factorsAnal sexMale partnersPostcoital bleedingFemale partnersCondom useHuman immunodeficiency virus (HIV) transmissionSexual contactAdvanced HIV infectionHuman immunodeficiency virusInconsistent condom useHIV positivityAIDS CenterHIV serostatusImmunodeficiency syndromeImmunodeficiency virusHeterosexual contactBleedingEligibility criteriaVaginal sexPartner studiesInfection
1995
Instability of Delayed-type Hypersensitivity Skin Test Anergy in Human Immunodeficiency Virus Infection
Caiaffa W, Graham N, Galai N, Rizzo R, Nelson K, Vlahov D. Instability of Delayed-type Hypersensitivity Skin Test Anergy in Human Immunodeficiency Virus Infection. JAMA Internal Medicine 1995, 155: 2111-2117. PMID: 7575072, DOI: 10.1001/archinte.1995.00430190107015.Peer-Reviewed Original ResearchConceptsHIV-seropositive subjectsHIV-seronegative subjectsCD4 cell countSkin test resultsDrug usersCell countDTH anergyDTH positivityDelayed-type hypersensitivity (DTH) skin testDelayed-type hypersensitivity anergyHuman immunodeficiency virus (HIV) infectionDTH skin testingSkin test anergyImmunodeficiency virus infectionCommunity-based cohortHuman immunodeficiency virusHypersensitivity skin testsCandida albicans antigenAnergy testingSerial skinCD4 cellsHIV statusSingle testSkin testingImmunodeficiency virusCompliance with universal precautions among health care workers at three regional hospitals
Gershon R, Vlahov D, Felknor S, Vesley D, Johnson P, Delcios G, Murphy L. Compliance with universal precautions among health care workers at three regional hospitals. American Journal Of Infection Control 1995, 23: 225-236. PMID: 7503434, DOI: 10.1016/0196-6553(95)90067-5.Peer-Reviewed Original ResearchMeSH KeywordsBlood-Borne PathogensChi-Square DistributionCooperative BehaviorFemaleHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansInfectious Disease Transmission, Patient-to-ProfessionalLogistic ModelsMaleMid-Atlantic RegionMidwestern United StatesMotivationOdds RatioOrganizational CulturePersonnel, HospitalRisk-TakingSocioeconomic FactorsSouthwestern United StatesUniversal PrecautionsConceptsHospital-based health care workersOverall compliance scoreHealth care workersUniversal precautionsCare workersCompliance scoreCompliance rateConfidential questionnaire surveyCompliance correlatesHIV transmissionCorrelates of complianceDistinct hospitalsCritical careRegional hospitalStratified convenience sampleModifiable variablesOverall complianceMedical carePatient specimensConflicts of interestCompliance ScaleConvenience sampleDemographic characteristicsMale workersSelf-reported levelsIncidence and Risk Factors for Human T-Lymphotropic Virus Type II Seroconversion Among Injecting Drug Users in Baltimore, Maryland, U.S.A
Vlahov D, Khabbaz R, Cohn S, Galai N, Taylor E, Kaplan J. Incidence and Risk Factors for Human T-Lymphotropic Virus Type II Seroconversion Among Injecting Drug Users in Baltimore, Maryland, U.S.A. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 9: 89-96. PMID: 7712239, DOI: 10.1097/00042560-199505010-00013.Peer-Reviewed Original ResearchConceptsRisk factorsDrug usersEnzyme immunoassayWestern blotHuman T-lymphotropic virusNeedle-sharing practicesRisk factor analysisT-lymphotropic virusMedian lag timeCase-control designALIVE studyRecent serumSeronegative IDUsStudy entryBaseline historyIncidence rateSeroconversionPositive casesSex partnersIDUsHTLVCalendar timeMonthsIncidenceBaseline