1998
Prognostic Indicators for AIDS and Infectious Disease Death in HIV-Infected Injection Drug Users: Plasma Viral Load and CD4+ Cell Count
Vlahov D, Graham N, Hoover D, Flynn C, Bartlett J, Margolick J, Lyles C, Nelson K, Smith D, Holmberg S, Farzadegan H. Prognostic Indicators for AIDS and Infectious Disease Death in HIV-Infected Injection Drug Users: Plasma Viral Load and CD4+ Cell Count. JAMA 1998, 279: 35-40. PMID: 9424041, DOI: 10.1001/jama.279.1.35.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsBiomarkersBlack or African AmericanCD4 Lymphocyte CountDisease ProgressionFemaleHIV-1HumansMalePrognosisProportional Hazards ModelsProspective StudiesRegression AnalysisRNA, ViralSubstance Abuse, IntravenousSurvival AnalysisViral LoadConceptsInfectious disease deathsInjection drug usersPlasma viral loadViral loadDisease deathsCell countDrug usersPrognostic indicatorHuman immunodeficiency virus type 1 (HIV-1) viral loadAfrican American injection drug usersPlasma HIV-1 RNAHIV-1 viral loadInfectious diseasesClinical AIDS diagnosisLevels of CD4Kaplan-Meier analysisHIV-1 RNAPrognosis of personsPowerful prognostic informationProportional hazards modelCases of AIDSGood predictive valueCell count measurementsMedian followCohort study
1997
Markers of response to zidovudine monotherapy among treated HIV seroconverters. Italian Seroconversion Study.
Rezza G, Galai N, Pezzotti P, Vlahov D, Graham N, Viale P, Angarano G. Markers of response to zidovudine monotherapy among treated HIV seroconverters. Italian Seroconversion Study. Antiviral Therapy 1997, 2: 167-74. PMID: 11322271.Peer-Reviewed Original ResearchConceptsCD4 cell countInitiation of treatmentZidovudine monotherapyP24 antigenaemiaCell countConstitutional symptomsHIV seroconvertersRisk groupsCopies/Human immunodeficiency virus seroconvertersPlasma RNA viral loadHIV RNA copiesCD4 cell declineRNA viral loadStart of therapyMarker of responseAntigen-positive individualsAdditional predictive informationIndicator of responseStandard survival methodsTerms of progressionAntiretroviral therapyViral loadAntigen levelsDisease progressionVitamin A levels and human immunodeficiency virus load in injection drug users.
Semba R, Farzadegan H, Vlahov D. Vitamin A levels and human immunodeficiency virus load in injection drug users. MSphere 1997, 4: 93-5. PMID: 9008289, PMCID: PMC170483, DOI: 10.1128/cdli.4.1.93-95.1997.Peer-Reviewed Original ResearchConceptsInjection drug usersInfectious viral loadHIV viral loadPlasma vitaminViral loadDrug usersHuman immunodeficiency virus (HIV) infectionPeripheral blood mononuclear cellsHuman immunodeficiency virus loadHigher vertical transmissionLow plasma vitaminImmunodeficiency virus infectionIndependent risk factorProspective cohort studyBlood mononuclear cellsEntire study populationCross-sectional studyHIV loadQuantitative microcultureCohort studyHIV infectionMononuclear cellsRisk factorsVirus loadLow vitamin
1995
Changes in Markers of Disease Progression in HIV-1 Seroconverters
Galai N, Vlahov D, Margolick J, Chen K, Graham N, Munoz A. Changes in Markers of Disease Progression in HIV-1 Seroconverters. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 8: 66-82. PMID: 8548349, DOI: 10.1097/00042560-199501000-00011.Peer-Reviewed Original ResearchConceptsHomosexual menDrug usersDisease progressionRisk groupsHuman immunodeficiency virus (HIV) disease progressionHIV-1 seroconversionHIV-1 seroconvertersT lymphocyte subsetsImmune deficiency syndromeWhite homosexual menCD8 percentagesTotal lymphocytesHIV infectionSimilar CD4HIV seroconvertersDeficiency syndromeInitial courseSeroconversionCD4Long incubation periodSeroconvertersMenCohortInfectionSimilar rates
1992
Immune Serum Markers and CD4 Cell Counts in HIV-Infected Intravenous Drug Users.
Chaisson R, Taylor E, Margolick J, Muñoz A, Solomon L, Cohn S, Nelson K, Vlahov D. Immune Serum Markers and CD4 Cell Counts in HIV-Infected Intravenous Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1992, 5: 456. PMID: 1348535, DOI: 10.1097/00126334-199205000-00004.Peer-Reviewed Original ResearchConceptsCD4 cell countSerum immune markersDrug use patternsCell countCD4 countHIV statusImmune markersImmune activationDrug usersHuman immunodeficiency virus (HIV) infectionHIV-seropositive individualsImmunodeficiency virus infectionSerum IgA levelsIntravenous drug usersAssociation of raceIgA levelsNeopterin levelsSerum markersVirus infectionLarge cohortBacterial infectionsHIVHepatitisInfectionMarkers