2013
Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population
Manini A, Jacobs M, Vlahov D, Hurd Y. Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population. Journal Of Medical Toxicology 2013, 9: 148-154. PMID: 23318993, PMCID: PMC3648633, DOI: 10.1007/s13181-012-0286-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternative SplicingAmino Acid SubstitutionBenzodiazepinesCohort StudiesDrug OverdoseFemaleFollow-Up StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHeart ArrestHumansMaleNarcoticsPilot ProjectsPolymorphism, Single NucleotideProspective StudiesReceptors, Opioid, muRespiratory InsufficiencySeverity of Illness IndexSympathomimeticsUnited StatesConceptsAcute drug overdoseG variant alleleClinical severityVariant allelesEmergency departmentDrug overdoseSingle nucleotide polymorphismsConsecutive adult ED patientsHuman mu-opioid receptor geneReceptor single nucleotide polymorphismsWorse clinical severityAdult ED patientsObservational cohort studyUrban teaching hospitalMu-opioid receptor geneAbove single nucleotide polymorphismsCohort studyED patientsRespiratory arrestCardiac arrestClinical variablesAcute drugSevere outcomesTeaching hospitalBlood samples
1998
Mycobacterium tuberculosis infection and disease are not associated with protection against subsequent disseminated M. avium complex disease
Sterling T, Moore R, Graham N, Astemborski J, Vlahov D, Chaisson R. Mycobacterium tuberculosis infection and disease are not associated with protection against subsequent disseminated M. avium complex disease. AIDS 1998, 12: 1451-1457. PMID: 9727565, DOI: 10.1097/00002030-199812000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAIDS-Related Opportunistic InfectionsAntibiotic ProphylaxisAntitubercular AgentsCD4 Lymphocyte CountCohort StudiesFemaleHumansMaleMiddle AgedMycobacterium avium ComplexMycobacterium avium-intracellulare InfectionMycobacterium tuberculosisProspective StudiesRisk FactorsSubstance Abuse, IntravenousTuberculosisConceptsM. tuberculosis infectionM. avium complex diseaseMycobacterium tuberculosis infectionDisseminated MACTuberculosis infectionExtrapulmonary tuberculosisDrug useLow CD4 cell levelsProspective observational cohort studyAdult HIV clinicIntravenous Experience cohortPrior opportunistic infectionsCD4 cell levelsObservational cohort studyLogistic regression analysisALIVE cohortAntibiotic prophylaxisMAC prophylaxisAntiretroviral therapyCD4 lymphocytesHIV clinicMAC diseaseActive tuberculosisCohort studyOpportunistic infections
1996
Effect of Isoniazid Chemoprophylaxis on HIV-Related Mycobacterial Disease
Graham N, Galai N, Nelson K, Astemborski J, Bonds M, Rizzo R, Sheeley L, Vlahov D. Effect of Isoniazid Chemoprophylaxis on HIV-Related Mycobacterial Disease. JAMA Internal Medicine 1996, 156: 889-894. PMID: 8774208, DOI: 10.1001/archinte.1996.00440080089010.Peer-Reviewed Original ResearchConceptsM avium complexMycobacterial diseaseTuberculosis incidenceAvium complexCutaneous anergyIsoniazid chemoprophylaxisIsoniazid prophylaxisPreventive therapyRisk factorsIncidence rateCD4 lymphocyte cell countProspective observational cohort studyPPD-positive patientsTwice-weekly isoniazidWeeks of therapyObservational cohort studyLymphocyte cell countsMonths of diagnosisOverall incidence rateAnnual incidence ratePopulation-based dataStrong risk factorTuberculin-positive subjectsMycobacterium avium complexTuberculin-positive individuals
1995
Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes.
Holmberg S, Conley L, Luby S, Cohn S, Wong L, Vlahov D. Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 9: 291. PMID: 7788428, DOI: 10.1097/00042560-199507000-00011.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCD4 T lymphocytesObservational cohort studyT lymphocytesCell countHIV seroconversionCohort studyHIV infectionImmunodeficiency virusOngoing observational cohort studyEarlier calendar yearsMore rapid declineLow CD4Mean CD4Recent infectionHIV-1CD4Drug usersBisexual menInfectionSeroconversionCalendar yearLymphocytesRapid lossFirst year