1998
Opiates as potential cofactors in progression of HIV-1 infections to AIDS
Donahoe R, Vlahov D. Opiates as potential cofactors in progression of HIV-1 infections to AIDS. Journal Of Neuroimmunology 1998, 83: 77-87. PMID: 9610676, DOI: 10.1016/s0165-5728(97)00224-5.Peer-Reviewed Original ResearchConceptsHIV-1 infectionEffects of opiatesOpiate useAIDS progressionEpidemiological studiesImmune processesCD4 T-cell countT-cell countsHIV-1 expressionHost protective responsesAssociation of AIDSOpiate exposureOpportunistic infectionsAIDS pathogenesisHIV-1Monkey modelOpiate abuseEpidemiological dataInfectious processClinical observationsProtective responseOpiatesInfectionAIDSDrug abuseGenetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Winkler C, Modi W, Smith M, Nelson G, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert J, O'Brien T, Jacobson L, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, Study A, Study H, Study M, Study M, Cohort S, O'Brien S. Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant. Science 1998, 279: 389-393. PMID: 9430590, DOI: 10.1126/science.279.5349.389.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultChemokine CXCL12ChemokinesChemokines, CXCCohort StudiesDisease ProgressionGenesGenetic VariationGenotypeHeterozygoteHIV InfectionsHIV-1HumansMaleMolecular Sequence DataOdds RatioPolymorphism, GeneticRacial GroupsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CXCR4Survival AnalysisT-LymphocytesConceptsSDF1-3'AGenetic restrictionRecessive protective effectOnset of AIDSAIDS Cohort StudyStromal-derived factorCohort studyImmunodeficiency syndromeAIDS pathogenesisHuman immunodeficiencyHIV-1Protective effectCommon polymorphismsReceptor variantsGene variantsPrincipal ligandAIDSHomozygous stateGenetic association analysisOnsetCD4CCR5PatientsGene transcriptsImmunodeficiency
1996
Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion
Pezzotti P, Phillips A, Dorrucci M, Lepri A, Galai N, Vlahov D, Rezza G. Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion. The BMJ 1996, 313: 583. PMID: 8806246, PMCID: PMC2352019, DOI: 10.1136/bmj.313.7057.583.Peer-Reviewed Original ResearchConceptsDate of seroconversionCategories of exposureExposure categoriesOlder subjectsInjected drugsMore rapid progressionHeterosexual sexLongitudinal studyHomosexual sexHIV treatmentAIDS pathogenesisUnivariate analysisRapid progressionAge effectsYoung subjectsHomosexual menHIVRate of developmentEvidence of differencesDisease controlAIDSSeroconversionSexAgeDefinitions of Center