2020
Forced Zika Virus Infection of Culex pipiens Leads to Limited Virus Accumulation in Mosquito Saliva
Abbo SR, Vogels CBF, Visser TM, Geertsema C, van Oers MM, Koenraadt CJM, Pijlman GP. Forced Zika Virus Infection of Culex pipiens Leads to Limited Virus Accumulation in Mosquito Saliva. Viruses 2020, 12: 659. PMID: 32575394, PMCID: PMC7354520, DOI: 10.3390/v12060659.Peer-Reviewed Original ResearchConceptsZika virusGuillain-Barré syndromeZika virus infectionInfectious blood mealUrban transmission cyclesMosquito-borne pathogenMosquito salivaZIKV transmissionOral exposureVirus infectionCongenital microcephalySevere diseaseIntrathoracic injectionLarge outbreakVirus disseminationUsutu virusMidgut barrierBarrier functionMosquito midgutVirus transmissionSalivaBlood mealYellow fever mosquitoVector competenceVirusThe invasive Asian bush mosquito Aedes japonicus found in the Netherlands can experimentally transmit Zika virus and Usutu virus
Abbo SR, Visser TM, Wang H, Göertz GP, Fros JJ, Abma-Henkens MHC, Geertsema C, Vogels CBF, Koopmans MPG, Reusken CBEM, Hall-Mendelin S, Hall RA, van Oers MM, Koenraadt CJM, Pijlman GP. The invasive Asian bush mosquito Aedes japonicus found in the Netherlands can experimentally transmit Zika virus and Usutu virus. PLOS Neglected Tropical Diseases 2020, 14: e0008217. PMID: 32282830, PMCID: PMC7153878, DOI: 10.1371/journal.pntd.0008217.Peer-Reviewed Original ResearchConceptsZika virusUsutu virusFed mosquitoesMidgut barrierMosquito midgut barrierGuillain-Barré syndromeInfectious blood mealSevere neurological impairmentSevere congenital microcephalyField-collected AeWest Nile virusClinical manifestationsMild diseaseUSUV infectionNeurological impairmentCongenital microcephalyRNA responseVirus disseminationArboviral diseasesNile virusVirus transmissionDroplet feedingVirusFemale mosquitoesBlood meal
2015
West Nile Virus: High Transmission Rate in North-Western European Mosquitoes Indicates Its Epidemic Potential and Warrants Increased Surveillance
Fros JJ, Geertsema C, Vogels CB, Roosjen PP, Failloux AB, Vlak JM, Koenraadt CJ, Takken W, Pijlman GP. West Nile Virus: High Transmission Rate in North-Western European Mosquitoes Indicates Its Epidemic Potential and Warrants Increased Surveillance. PLOS Neglected Tropical Diseases 2015, 9: e0003956. PMID: 26225555, PMCID: PMC4520649, DOI: 10.1371/journal.pntd.0003956.Peer-Reviewed Original ResearchConceptsWest Nile virusEpidemic potentialLineage 1 West Nile VirusInfectious blood mealFurther epidemic spreadLineage 2 West Nile virusNeuroinvasive diseaseIntrathoracic injectionEuropean mosquitoesPathogenic flavivirusesInfection rateVirus activityLarge outbreakVirus disseminationWNV infection ratesNile virusWNV activityWNV lineagesBlood mealVector competenceInfectionCulex pipiens mosquitoesWNV transmissionEpidemic spreadDisease-free regions