2013
Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity
Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity. Epidemiology 2013, 24: 320-330. PMID: 23337243, PMCID: PMC3686297, DOI: 10.1097/ede.0b013e318280e2ac.Peer-Reviewed Original ResearchConceptsAsthma severityNight symptomsAsthma morbiditySeverity scoreNO2 exposureHigher asthma severity scoresFrequency of wheezeIndoor NO2 exposurePediatric asthma severityRescue medication useIndoor allergen exposureAsthma severity scoreAdverse respiratory effectsDose-dependent increaseYears of ageInner-city childrenLogistic regression modelsRescue medicationActive asthmaAllergen exposureAsthmatic childrenMedication useRespiratory effectsChildren 5Health outcomes
1995
Effect of nitrous acid on lung function in asthmatics: a chamber study.
Beckett W, Russi M, Haber A, Rivkin R, Sullivan J, Tameroglu Z, Mohsenin V, Leaderer B. Effect of nitrous acid on lung function in asthmatics: a chamber study. Environmental Health Perspectives 1995, 103: 372-375. PMID: 7607138, PMCID: PMC1519093, DOI: 10.1289/ehp.95103372.Peer-Reviewed Original ResearchConceptsSignificant airflow obstructionChamber exposure studiesFiltered room airModerate cycle exerciseNitrous acid exposureIndoor nitrogen dioxideMucous membrane symptomsDuration of exposureAirflow obstructionLung functionIrritant symptomsVital capacityCycle exerciseLung mechanicsRespiratory effectsAcid exposureRespiratory parametersAdult subjectsRoom airHealth effectsSymptomsSignificant decreaseAsthmaticsExposure studiesCommon indoor air pollutants
1987
A study of respiratory effects from exposure to 2.0 ppm formaldehyde in occupationally exposed workers
Schachter E, Witek T, Brody D, Tosun T, Beck G, Leaderer B. A study of respiratory effects from exposure to 2.0 ppm formaldehyde in occupationally exposed workers. Environmental Research 1987, 44: 188-205. PMID: 3691441, DOI: 10.1016/s0013-9351(87)80227-x.Peer-Reviewed Original ResearchConceptsPeak expiratory flow rateLung functionLaboratory workersExposure daysHospital laboratory workersLower airway symptomsLung function changesHealthy laboratory workersExpiratory flow rateAirway symptomsObstructive changesAsthmatic individualsIrritative symptomsSymptom diaryExercise regimenAsthmatic symptomatologyMild exerciseRespiratory effectsPEFR recordingsFrequent complaintEye irritationMore occasionsSymptomsPpm formaldehydeUnusual odorAn evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics: lung function, symptoms, and airway reactivity.
Witek T, Schachter E, Tosun T, Beck G, Leaderer B. An evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics: lung function, symptoms, and airway reactivity. Archives Of Environmental & Occupational Health 1987, 42: 230-7. PMID: 3310924.Peer-Reviewed Original ResearchConceptsMethacholine inhalation challenge testFlow-volume parametersInhalation challenge testSignificant airway obstructionAirway reactivityAirway obstructionAirway responsesAsthmatic volunteersLung functionSore throatAirway resistanceMethacholine concentrationModerate exerciseRespiratory effectsFormaldehyde exposurePpm exposureChallenge testSeparate daysEye irritationMedian decrementAsthmaticsSymptomsExposurePpm formaldehydeDegrees C
1986
A Study of Respiratory Effects from Exposure to 2 ppm Formaldehyde in Healthy Subjects
Schachter E, Witek T, Tosun T, Leaderer B, Beck G. A Study of Respiratory Effects from Exposure to 2 ppm Formaldehyde in Healthy Subjects. Archives Of Environmental & Occupational Health 1986, 41: 229-239. PMID: 3767432, DOI: 10.1080/00039896.1986.9938338.Peer-Reviewed Original ResearchConceptsHealthy subjectsUpper airwaySeparate daysMaximal flow-volume curvesLower airway symptomsFlow-volume curvesAirway responsesAirway symptomsPulmonary functionRespiratory symptomsSignificant bronchoconstrictionLung functionSymptom diaryAirway resistanceIrritative phenomenaModerate exercisePhysiologic alterationsRespiratory effectsSubjective complaintsBaseline responsivenessFA exposureHealthy individualsIrritative propertiesRespiratory systemSuch exposure
1984
Airway Effects of Low Concentrations of Sulfur Dioxide: Dose-Response Characteristics
Schachter E, Witek T, Beck G, Hosein H, Colice G, Leaderer B, Cain W. Airway Effects of Low Concentrations of Sulfur Dioxide: Dose-Response Characteristics. Archives Of Environmental & Occupational Health 1984, 39: 34-42. PMID: 6370145, DOI: 10.1080/00039896.1984.10545831.Peer-Reviewed Original ResearchConceptsAsthmatic subjectsVital capacityPartial flow-volume curvesAcute respiratory effectsTotal lung capacityMaximal expiratory flowAbsence of exerciseKpm/minEnd of exerciseFlow-volume curvesDose-response relationshipDose-response characteristicsAirway effectsExpiratory volumeAirway resistanceLung capacitySignificant changesExpiratory flowRespiratory effectsHealthy subjectsHealthy individualsSeparate daysMin subjectsVolume curvesVmax50