2024
Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE)
Rodwin R, Wang F, Lu L, Li Z, Srivastava D, Phillips N, Khan R, Brinkman T, Krull K, Boop F, Armstrong G, Merchant T, Gajjar A, Robison L, Hudson M, Kadan‐Lottick N, Ness K. Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE). Cancer Medicine 2024, 13: e7422. PMID: 39056576, PMCID: PMC11273544, DOI: 10.1002/cam4.7422.Peer-Reviewed Original ResearchConceptsSt. Jude Lifetime CohortQuality of lifeChildhood central nervous systemSurvivors of childhood CNS tumorsSensory impairmentChildhood CNS tumorsImpaired physical quality of lifeCentral nervous systemPhysical quality of lifeMotor impairmentCNS tumorsCommon Terminology Criteria for Adverse EventsModified total neuropathy scoreMultivariate modelIn-person evaluationAssociated with older ageClinical assessmentTotal Neuropathy ScoreNervous systemExposure to etoposideModified Common Terminology Criteria for Adverse EventsPrevalence of motorTreating motor impairmentIn-personCraniospinal irradiationSevere Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors
Goggin K, Lu L, Lee D, Howell C, Srivastava D, Brinkman T, Armstrong G, Bhakta N, Robison L, Ehrhardt M, Hudson M, Krull K, Pui C, Rubnitz J, Ness K, Wolf J. Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors. JAMA Network Open 2024, 7: e242727. PMID: 38497960, PMCID: PMC10949094, DOI: 10.1001/jamanetworkopen.2024.2727.Peer-Reviewed Original ResearchConceptsChronic health conditionsHealth conditionsAdult survivorsCohort studyAdult survivors of childhood cancerSt Jude Lifetime Cohort StudyIncidence of chronic health conditionsChildhood leukemiaSurvivors of childhood cancerAssociated with long-term riskIncreased riskMedical record reviewQuality of lifeInverse propensity score weightingAdult survivors of childhood leukemiaYear of diagnosisCancer survivorsSevere sepsisPropensity score weightingSurvivors of childhood leukemiaMain OutcomesPotential confoundersChildhood cancerRecord reviewLong-term risk
2021
“Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study”
Bade BC, Gan G, Li F, Lu L, Tanoue L, Silvestri GA, Irwin ML. “Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study”. BMC Cancer 2021, 21: 352. PMID: 33794808, PMCID: PMC8015735, DOI: 10.1186/s12885-021-08084-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorExerciseFemaleHumansLung NeoplasmsMaleNeoplasm StagingPilot ProjectsQuality of LifeConceptsNon-small cell lung cancerAdvanced-stage lung cancerStage lung cancerUsual carePhysical activityIntervention groupQuality of lifeLung cancerEligible patientsStage III/IV non-small cell lung cancerLow baseline physical activityHome-based physical activityAdvanced stage diseaseSoluble PD-1Stage IV adenocarcinomaBaseline physical activityMinority of patientsCell lung cancerPatient-reported outcomesEffects of exerciseRole functioning domainsLung cancer biologyAspects of QoL.Mobile health interventionsCancer biomarkers
2020
Risk‐stratifying clinicopathologic criteria for ovarian preservation in premenopausal women with early stage low‐risk endometrial cancer
Khadraoui W, Tierney C, Chung S, Mutlu L, Lu L, Azodi M, Ratner E, Menderes G. Risk‐stratifying clinicopathologic criteria for ovarian preservation in premenopausal women with early stage low‐risk endometrial cancer. International Journal Of Gynecology & Obstetrics 2020, 150: 385-391. PMID: 32506422, DOI: 10.1002/ijgo.13254.Peer-Reviewed Original ResearchConceptsEarly-stage diseaseEndometrioid endometrial cancerEndometrial cancerOvarian preservationPremenopausal womenStage diseaseMetastatic diseaseGrade 1 endometrioid endometrial cancerEarly-stage endometrial cancerLow-risk endometrial cancerEarly-stage endometrioid endometrial cancerStage endometrial cancerStage II diseaseSingle institutional databaseFrozen section specimenQuality of lifeSignificant health benefitsIIA diseaseAdnexal involvementStage IAEndometrial biopsyOvarian involvementRetrospective reviewMyometrial biopsiesClinicopathologic criteria
2018
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
Sanft T, Usiskin I, Harrigan M, Cartmel B, Lu L, Li FY, Zhou Y, Chagpar A, Ferrucci LM, Pusztai L, Irwin ML. Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study. Breast Cancer Research And Treatment 2018, 172: 105-112. PMID: 30062572, DOI: 10.1007/s10549-018-4895-7.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsWeight loss interventionUsual care groupBody mass indexBreast cancer riskCancer survivorsUsual careLoss interventionBreast cancerStage 0Quantitative polymerase chain reactionCare groupTelomere lengthCancer riskStage II/III breast cancerObese breast cancer survivorsWeight lossI breast cancerNon-Hispanic whitesPurposeSome studiesMass indexIntervention groupPhysical activityBlood samplesConclusionOur findingsPeripheral Neuropathy, Sensory Processing, and Balance in Survivors of Acute Lymphoblastic Leukemia.
Varedi M, Lu L, Howell C, Partin R, Hudson M, Pui C, Krull K, Robison L, Ness K, McKenna R. Peripheral Neuropathy, Sensory Processing, and Balance in Survivors of Acute Lymphoblastic Leukemia. Journal Of Clinical Oncology 2018, 36: 2315-2322. PMID: 29812998, PMCID: PMC6067801, DOI: 10.1200/jco.2017.76.7871.Peer-Reviewed Original ResearchConceptsAdult survivors of childhood acute lymphoblastic leukemiaWalking enduranceStatic balanceAdult survivorsStatic standing balanceAdult survivors of childhood ALLSurvivors of childhood ALLTimed Up andAnterior-posterior swayChildhood ALLALL survivorsAssessment of PNVisual motor processing speedLong-term ALL survivorsSurvivors of acute lymphoblastic leukemiaQuality of lifeSurvivors of childhood acute lymphoblastic leukemiaStanding balanceBalance impairmentCancer historyAssociated with longer timePeripheral neuropathyReduced QoLQoLEndurance