2000
Diflubenzuron, a Benzoyl-Urea Insecticide, Is a Potent Inhibitor of TCDD-Induced CYP1A1 Expression in HepG2 Cells
Ledirac N, Delescluse C, Lesca P, Piechocki M, Hines R, de Sousa G, Pralavorio M, Rahmani R. Diflubenzuron, a Benzoyl-Urea Insecticide, Is a Potent Inhibitor of TCDD-Induced CYP1A1 Expression in HepG2 Cells. Toxicology And Applied Pharmacology 2000, 164: 273-279. PMID: 10799337, DOI: 10.1006/taap.2000.8920.Peer-Reviewed Original ResearchConceptsCYP1A1 expressionEthoxyresorufin-O-deethylase (EROD) activityHepG2 cellsStrong dose-dependent decreaseDose-dependent decreaseB16 murine melanomaHuman hepatoma cells HepG2Receptor antagonismTreatment of HepG2Hepatoma cells HepG2Human CYP1A1 promoterParental HepG2 cellsCYP1A1 inducerNoncytotoxic concentrationsMurine melanomaChloramphenicol acetyltransferase (CAT) reporter geneAdditional studiesCYP1A1 inductionNorthern blot analysisCell linesBlot analysisSynthesis inhibitorH exposurePotent inhibitorAh receptor
1994
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor
Thomsen J, Wang X, Hines R, Safe S. Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis 1994, 15: 933-937. PMID: 8200098, DOI: 10.1093/carcin/15.5.933.Peer-Reviewed Original ResearchConceptsMDA-MB-231 cellsHuman breast cancer cellsMDA-MB-231 human breast cancer cellsAh-responsivenessBreast cancer cellsNM TCDDHuman estrogen receptor expression plasmidAryl hydrocarbon responsivenessCancer cellsReceptor expression plasmidAryl hydrocarbon receptorProgesterone receptorEstrogen receptorResponsive plasmidCYP1A1 gene expressionHydrocarbon receptorReceptorsCell linesCYP1A1 geneCAT activityExpression of nuclearParallel studyHuman CYP1A1 geneCellsExpression plasmid
1991
Differences in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans‐acting factors
THOMSEN J, NISSEN L, STACEY S, HINES R, AUTRUP H. Differences in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans‐acting factors. The FEBS Journal 1991, 197: 577-582. PMID: 2029891, DOI: 10.1111/j.1432-1033.1991.tb15946.x.Peer-Reviewed Original Research
1988
Induction of cytochrome P-450IA1 gene expression in human breast tumour cell lines
Pasanen M, Stacey S, Lykkesfeldt A, Briand P, Hines R, Autrup H. Induction of cytochrome P-450IA1 gene expression in human breast tumour cell lines. Chemico-Biological Interactions 1988, 66: 223-232. PMID: 2456161, DOI: 10.1016/0009-2797(88)90073-7.Peer-Reviewed Original ResearchConceptsBreast tumor cell linesHuman breast tumor cell linesTumor cell linesTCDD treatmentCell linesDifferent breast tumor cell linesConcentrations of TCDDZR-75BT-20Cytochrome P-450IA1NM TCDDCAMA-1Basal expression levelsControl cellsExpression levelsMCF-7Northern blot analysisBlot analysisTCDDTreatmentTotal RNAP-450IA1TCDD inductionDiol metabolitesInduction