2020
Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids
Mallick P, Song G, Efremenko A, Pendse S, Creek M, Osimitz T, Hines R, Hinderliter P, Clewell H, Lake B, Yoon M, Moreau M. Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids. Toxicological Sciences 2020, 176: 460-469. PMID: 32421774, PMCID: PMC7416317, DOI: 10.1093/toxsci/kfaa070.Peer-Reviewed Original ResearchConceptsAge-related pharmacokinetic differencesPharmacokinetic differencesPBPK modelTarget tissue exposureAge-related sensitivityHuman PBPK modelAge-dependent changesAge-related differencesRat modelTissue exposureVivo rat dataPharmacokinetic modellingPharmacokinetic modelingInternal exposureRat dataRisk assessmentVivo extrapolationRisk assessment purposesExposureAdultsExternal exposureSensitive populationsChildrenMetabolic capacityAssessment
2017
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages
Song G, Sun X, Hines R, McCarver D, Lake B, Osimitz T, Creek M, Clewell H, Yoon M. Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. Drug Metabolism And Disposition 2017, 45: dmd.116.074583. PMID: 28228413, DOI: 10.1124/dmd.116.074583.Peer-Reviewed Original ResearchConceptsCYP2C8 expressionOntogeny dataMonths postnatal ageProtein levelsLiver microsomal samplesAge-dependent expressionMultiple cytochrome P450Weeks' gestationPostnatal agePostnatal dayYoung infantsPostnatal samplesFetal samplesMicrosomal samplesCYP1A2 expressionQuantitative Western blottingPyrethroid metabolismCYP2C8Western blottingHealth risk assessmentHuman health risk assessmentRisk assessmentAgeCarboxylesterase enzymesCytochrome P450
2016
Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards
El-Masri H, Kleinstreuer N, Hines R, Adams L, Tal T, Isaacs K, Wetmore B, Tan Y. Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards. Toxicological Sciences 2016, 152: 230-243. PMID: 27208077, PMCID: PMC5009469, DOI: 10.1093/toxsci/kfw082.Peer-Reviewed Original ResearchConceptsPutative adverse outcome pathwayExposure levelsPharmacokinetic modelAdverse outcome pathwaysPotential exposure levelsFetal blood levelsExternal exposure levelsMaternal exposureBlood levelsExposure modelHigh-throughput toxicity screeningVasculogenesis/angiogenesisOutcome pathwaysPBPK modelExposure estimatesChemical dispositionDevelopmental toxicityPotential exposureVivo extrapolationExposureAdulthood stagesToxicityAssaysEnvironmental exposure modelsPregnancy
2015
Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting
Doe J, Lander D, Doerrer N, Heard N, Hines R, Lowit A, Pastoor T, Phillips R, Sargent D, Sherman J, Tanir J, Embry M. Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting. Critical Reviews In Toxicology 2015, 46: 54-73. PMID: 26517449, PMCID: PMC4732465, DOI: 10.3109/10408444.2015.1082974.Peer-Reviewed Original ResearchCurrent Research and Opportunities to Address Environmental Asbestos Exposures
Carlin D, Larson T, Pfau J, Gavett S, Shukla A, Miller A, Hines R. Current Research and Opportunities to Address Environmental Asbestos Exposures. Environmental Health Perspectives 2015, 123: a194-a197. PMID: 26230287, PMCID: PMC4529018, DOI: 10.1289/ehp.1409662.Peer-Reviewed Original ResearchMeSH KeywordsAsbestosAsbestosisEnvironmental ExposureEnvironmental PollutantsEnvironmental Restoration and RemediationHumansRisk AssessmentConceptsEnvironmental asbestos exposureAsbestos exposureAsbestos-related diseasesHealth effectsRisk factorsOccupational exposureBasic research findingsDisease RegistryEnvironmental Health SciencesToxicological findingsTumor developmentSociety of ToxicologyHazardous exposuresPotential health risksDose metricsNational InstituteSusceptible populationPublic healthHigh rateAsbestosHealth risksDiseaseExposureProper dose metricToxicity
2014
Risk assessment in the 21st century: Roadmap and matrix
Embry M, Bachman A, Bell D, Boobis A, Cohen S, Dellarco M, Dewhurst I, Doerrer N, Hines R, Moretto A, Pastoor T, Phillips R, Rowlands J, Tanir J, Wolf D, Doe J. Risk assessment in the 21st century: Roadmap and matrix. Critical Reviews In Toxicology 2014, 44: 6-16. PMID: 25070414, DOI: 10.3109/10408444.2014.931924.Peer-Reviewed Original ResearchA 21st century roadmap for human health risk assessment
Pastoor T, Bachman A, Bell D, Cohen S, Dellarco M, Dewhurst I, Doe J, Doerrer N, Embry M, Hines R, Moretto A, Phillips R, Rowlands J, Tanir J, Wolf D, Boobis A. A 21st century roadmap for human health risk assessment. Critical Reviews In Toxicology 2014, 44: 1-5. PMID: 25070413, DOI: 10.3109/10408444.2014.931923.Peer-Reviewed Original Research
2010
Human and environmental health challenges for the next decade (2010–2020)
Bonnefoi M, Belanger S, Devlin D, Doerrer N, Embry M, Fukushima S, Harpur E, Hines R, Holsapple M, Kim J, MacDonald J, O’Lone R, Pettit S, Stevens J, Takei A, Tinkle S, van der Laan J. Human and environmental health challenges for the next decade (2010–2020). Critical Reviews In Toxicology 2010, 40: 893-911. PMID: 20854192, DOI: 10.3109/10408444.2010.506640.Peer-Reviewed Original ResearchConceptsKey governmentEnvironmental health challengesGovernment agenciesMapping exerciseScientific portfolioNext decadeResearch institutionsRegulatory challengesFuture landscapeEnvironmental communityIndividual companiesKey challengesRegulatory authoritiesPublic healthHealth challengesSignificant issue
2009
Approaches for Assessing Risks to Sensitive Populations: Lessons Learned from Evaluating Risks in the Pediatric Population
Hines R, Sargent D, Autrup H, Birnbaum L, Brent R, Doerrer N, Hubal E, Juberg D, Laurent C, Luebke R, Olejniczak K, Portier C, Slikker W. Approaches for Assessing Risks to Sensitive Populations: Lessons Learned from Evaluating Risks in the Pediatric Population. Toxicological Sciences 2009, 113: 4-26. PMID: 19770482, PMCID: PMC3469276, DOI: 10.1093/toxsci/kfp217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsBiomarkersChildChild, PreschoolDose-Response Relationship, DrugEnvironmental ExposureEnvironmental MonitoringGenetic Predisposition to DiseaseGovernment RegulationHealth PolicyHumansInfantInfant, NewbornModels, BiologicalPharmacokineticsPublic HealthRisk AssessmentRisk FactorsToxicity Tests
2003
Workshop Overview: Use of Genomic Data in Risk Assessment
Cunningham M, Bogdanffy M, Zacharewski T, Hines R. Workshop Overview: Use of Genomic Data in Risk Assessment. Toxicological Sciences 2003, 73: 209-215. PMID: 12700425, DOI: 10.1093/toxsci/kfg071.Peer-Reviewed Original ResearchConceptsGenomic technologiesGenomic researchHigh-throughput genomic technologiesHigh-throughput proteomicsHuman Genome ProjectPosttranslational eventsGenetic compositionThroughput proteomicsNew high-throughput genomic technologiesGenetic variabilityGenome ProjectGenomic dataDNA microarraysDifferent genesExpression levelsSpecific cellsGenesToxicological responsesToxicant exposureRecent advancesProteomicsMicroarrayBetter understandingIndividual adaptiveExpression