2008
Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition
Hines R, Koukouritaki S, Poch M, Stephens M. Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition. Drug Metabolism Reviews 2008, 40: 263-301. PMID: 18464046, DOI: 10.1080/03602530801952682.Peer-Reviewed Original ResearchConceptsRegulatory polymorphismsRegulatory sequencesHuman proteinsSelection pressureGene expressionCo-dominant traitEvolutionary perspectiveXenobiotic metabolismEnvironmental changesToxicant dispositionUnexpected paucityCurrent understandingHeterozygous stateTraitsPolymorphismSuch variationExpressionKnowledge gapsGenesProteinFitnessSequenceMetabolismVariationDrug disposition
1994
A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities
Lawton M, Cashman J, Cresteil T, Dolphin C, Elfarra A, Hines R, Hodgson E, Kimura T, Ozols J, Phillips I, Philpot R, Poulsen L, Rettie A, Shephard E, Williams D, Ziegler D. A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities. Archives Of Biochemistry And Biophysics 1994, 308: 254-257. PMID: 8311461, DOI: 10.1006/abbi.1994.1035.Peer-Reviewed Original ResearchConceptsAmino acid sequenceGene familyAcid sequenceMammalian FMOsMammalian flavinFMO gene familySingle gene familyGene designationIndividual genesOrthologous formsPercentage identitySpecies linesGenesEnzymeFlavinSequenceFMO4FamilyUnambiguous identificationRelated formsFMO1OrthologsFMO2FMO3Nomenclature