The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms
McCarver D, Hines R. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. Journal Of Pharmacology And Experimental Therapeutics 2002, 300: 361-366. PMID: 11805192, DOI: 10.1124/jpet.300.2.361.Peer-Reviewed Original ResearchConceptsDrug-metabolizing enzyme expressionFetal liverN-acetyltransferase 1 (NAT1) activitiesPhase II conjugation enzymeHuman drug metabolizing enzymesEnzyme expressionDrug metabolizing enzymesPaucity of dataPhase II enzymesCCAAT/enhancer binding protein (C/EBP) familyHepatocyte nuclear factorSecond trimesterAdrenal glandHepatic expressionPostnatal changesNAT1 expressionFetal expressionNuclear factorUDP-glucuronosyltransferasePhase ILiverSulfotransferase isoformsRelated factorsIsoform expression patternLimited data