2019
A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes
Matlock M, Tambe A, Elliott-Higgins J, Hines R, Miller G, Swamidass S. A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes. Chemical Research In Toxicology 2019, 32: 1707-1721. PMID: 31304741, PMCID: PMC6933754, DOI: 10.1021/acs.chemrestox.9b00223.Peer-Reviewed Original ResearchConceptsAge-dependent changesHepatic Drug Metabolizing EnzymesAdverse drug reactionsValproic acid toxicityDrug metabolizing enzymesDrug metabolism enzymesElimination of drugsPediatric patientsPediatric populationMetabolite exposureDrug reactionsClinical dataElevated riskOverall clearanceDrug toxicityFunction of ageDrug safetyFetal periodMetabolizing enzymesDrug metabolismDrug toxicity risksPotential mechanismsAcid toxicityEnzyme expressionDemographic factors
1997
Variation in Induction of Human Placental CYP2E1: Possible Role in Susceptibility to Fetal Alcohol Syndrome?
Rasheed A, Hines R, McCarver-May D. Variation in Induction of Human Placental CYP2E1: Possible Role in Susceptibility to Fetal Alcohol Syndrome? Toxicology And Applied Pharmacology 1997, 144: 396-400. PMID: 9194424, DOI: 10.1006/taap.1997.8152.Peer-Reviewed Original ResearchConceptsFetal alcohol syndromeAlcohol syndromeIntersubject variationHeavy drinking womenSmall birth weightAbsolute alcohol intakeWestern blot analysisBirth lengthAlcohol intakeDrinking womenHepatic CYP2E1Birth weightTerm placentaHeavy drinkersAlcohol metabolismCYP2E1Placental microsomesHuman placentaHeavy drinkingPlacentaTime pointsPotential mechanismsEnvironmental agentsWomenPregnancy