2012
Amine Oxidases and Reductases
Hines R, Prough R. Amine Oxidases and Reductases. 2012, 1-27. DOI: 10.1002/9780470921920.edm012.Peer-Reviewed Original ResearchNatural environmental chemicalsCytochrome P450-dependent monooxygenasesP450-dependent monooxygenasesAmine oxidationVariety of compoundsParticular reactionAmine oxidaseEnvironmental chemicalsEnzymeGenesMonooxygenasesProteinReductaseEndogenous aminesVariety of drugsOxidationAminesCompoundsOxidaseReactionChemicalsVariety
2008
Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition
Hines R, Koukouritaki S, Poch M, Stephens M. Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition. Drug Metabolism Reviews 2008, 40: 263-301. PMID: 18464046, DOI: 10.1080/03602530801952682.Peer-Reviewed Original ResearchConceptsRegulatory polymorphismsRegulatory sequencesHuman proteinsSelection pressureGene expressionCo-dominant traitEvolutionary perspectiveXenobiotic metabolismEnvironmental changesToxicant dispositionUnexpected paucityCurrent understandingHeterozygous stateTraitsPolymorphismSuch variationExpressionKnowledge gapsGenesProteinFitnessSequenceMetabolismVariationDrug disposition
2003
Workshop Overview: Use of Genomic Data in Risk Assessment
Cunningham M, Bogdanffy M, Zacharewski T, Hines R. Workshop Overview: Use of Genomic Data in Risk Assessment. Toxicological Sciences 2003, 73: 209-215. PMID: 12700425, DOI: 10.1093/toxsci/kfg071.Peer-Reviewed Original ResearchConceptsGenomic technologiesGenomic researchHigh-throughput genomic technologiesHigh-throughput proteomicsHuman Genome ProjectPosttranslational eventsGenetic compositionThroughput proteomicsNew high-throughput genomic technologiesGenetic variabilityGenome ProjectGenomic dataDNA microarraysDifferent genesExpression levelsSpecific cellsGenesToxicological responsesToxicant exposureRecent advancesProteomicsMicroarrayBetter understandingIndividual adaptiveExpressionGenotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis
Zheng Y, Henne K, Charmley P, Kim R, McCarver D, Cabacungan E, Hines R, Rettie A. Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis. Toxicology And Applied Pharmacology 2003, 186: 119-126. PMID: 12639503, DOI: 10.1016/s0041-008x(02)00028-5.Peer-Reviewed Original ResearchConceptsHeme bindingArg motifAmino acid sequence alignmentNonhuman primate speciesPrimate speciesRedox partner interactionsSite-directed mutagenesisCYP4B1 geneRestriction enzyme fragment length polymorphismArg triadFragment length polymorphismRabbit CYP4B1Sequence alignmentHuman allelesN-terminalCatalytic functionCommon laboratory animalsAmino acidsPro residuesLength polymorphismMeander regionHuman populationDistal ArgGenesGlu-Arg
2002
Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression
Koukouritaki S, Simpson P, Yeung C, Rettie A, Hines R. Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression. Pediatric Research 2002, 51: 236-243. PMID: 11809920, DOI: 10.1203/00006450-200202000-00018.Peer-Reviewed Original ResearchConceptsFlavin-containing monooxygenasesExpression patternsSpecies-specific expression patternsFMO3 expressionTemporal expression patternsMajor adult isoformFMO genesPotential control mechanismsDevelopmental expressionProtein levelsAdult isoformsWestern blottingExpressionEmbryosNumerous therapeuticsIsoformsMonooxygenases 1Most individualsFMO3Microsomal fractionHuman liver samplesIntermediate levelsControl mechanismsGenesPrecise timing
2001
Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors.
Hines R, Luo Z, Cresteil T, Ding X, Prough R, Fitzpatrick J, Ripp S, Falkner K, Ge N, Levine A, Elferink C. Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors. Drug Metabolism And Disposition 2001, 29: 623-33. PMID: 11302926.Peer-Reviewed Original ResearchConceptsDevelopmental-specific expressionSignal transduction pathwaysMolecular regulationTransduction pathwaysCommon signal transduction pathwayReceptor-mediated signal transduction pathwaysRegulation of xenobioticGenome levelTranscription factorsMolecular mechanismsMolecular biologyEndogenous factorsGenesRegulatory systemXenobiotic-metabolizing enzymesEnzymeRegulationExpressionCytochrome P450Fundamental rolePathwayRapid proliferationTissueBiologyExperimental therapeutics
1994
A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities
Lawton M, Cashman J, Cresteil T, Dolphin C, Elfarra A, Hines R, Hodgson E, Kimura T, Ozols J, Phillips I, Philpot R, Poulsen L, Rettie A, Shephard E, Williams D, Ziegler D. A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities. Archives Of Biochemistry And Biophysics 1994, 308: 254-257. PMID: 8311461, DOI: 10.1006/abbi.1994.1035.Peer-Reviewed Original ResearchConceptsAmino acid sequenceGene familyAcid sequenceMammalian FMOsMammalian flavinFMO gene familySingle gene familyGene designationIndividual genesOrthologous formsPercentage identitySpecies linesGenesEnzymeFlavinSequenceFMO4FamilyUnambiguous identificationRelated formsFMO1OrthologsFMO2FMO3Nomenclature