2007
Regulation of CYP3A4 Expression by PAR Transcription Factors
Mantei K, Le M, Klick D, Vyhlidal C, Hines R. Regulation of CYP3A4 Expression by PAR Transcription Factors. The FASEB Journal 2007, 21: a1183-a1183. DOI: 10.1096/fasebj.21.6.a1183-a.Peer-Reviewed Original ResearchD-element binding proteinCYP3A4 expressionHepatic leukemia factorCYP3A4 promoter activityAdult human liverAbundant cytochrome P450CYP3A4 promoterHuman liverPostnatal liverProtein 4DBP expressionPAR familyEmbryonic factorsHepG2 cellsTranscription factorsCytochrome P450LiverFunctional significanceCo-transfection experimentsBinding proteinPromoter activityExpressionReporter constructsFactorsFactor family
1998
A Genetic Polymorphism in the Regulatory Sequences of HumanCYP2E1:Association with Increased Chlorzoxazone Hydroxylation in the Presence of Obesity and Ethanol Intake
McCarver D, Byun R, Hines R, Hichme M, Wegenek W. A Genetic Polymorphism in the Regulatory Sequences of HumanCYP2E1:Association with Increased Chlorzoxazone Hydroxylation in the Presence of Obesity and Ethanol Intake. Toxicology And Applied Pharmacology 1998, 152: 276-281. PMID: 9772223, DOI: 10.1006/taap.1998.8532.Peer-Reviewed Original ResearchConceptsMetabolic abilitiesDNA samplesHuman DNA samplesDNA insertionRegulatory sequencesRegulatory regionsXbaI fragmentGenomic probesRegulatory polymorphismsRestriction enzyme XbaIRestriction enzyme digestionSame DNA samplesInsertion mutationsUpstream regionRestriction enzymesSouthern blotFunctional significanceSouthern blottingMutationsEnzyme XbaIEnzyme digestionGenetic polymorphismsVivo CYP2E1 activity