2007
Regulation of CYP3A4 Expression by PAR Transcription Factors
Mantei K, Le M, Klick D, Vyhlidal C, Hines R. Regulation of CYP3A4 Expression by PAR Transcription Factors. The FASEB Journal 2007, 21: a1183-a1183. DOI: 10.1096/fasebj.21.6.a1183-a.Peer-Reviewed Original ResearchD-element binding proteinCYP3A4 expressionHepatic leukemia factorCYP3A4 promoter activityAdult human liverAbundant cytochrome P450CYP3A4 promoterHuman liverPostnatal liverProtein 4DBP expressionPAR familyEmbryonic factorsHepG2 cellsTranscription factorsCytochrome P450LiverFunctional significanceCo-transfection experimentsBinding proteinPromoter activityExpressionReporter constructsFactorsFactor family
2005
MOLECULAR MECHANISMS REGULATING HUMAN CYP4B1 LUNG-SELECTIVE EXPRESSION
Poch M, Cutler N, Yost G, Hines R. MOLECULAR MECHANISMS REGULATING HUMAN CYP4B1 LUNG-SELECTIVE EXPRESSION. Drug Metabolism And Disposition 2005, 33: 1174-1184. PMID: 15900016, DOI: 10.1124/dmd.105.004523.Peer-Reviewed Original ResearchConceptsDistal regulatory elementsRegulatory elementsTransient expressionCompetitive electrophoretic mobility shift assaysDNA/protein binding assaysKrüppel-like factor (KLF) familyElectrophoretic mobility shift assaysTranscription factor recognition sequenceChromatin immunoprecipitation assaysTranscription factor sitesProximal elementMobility shift assaysHepG2 hepatoblastoma cellsProtein binding assaysSp1 bindingSp1 elementImmunoprecipitation assaysNuclear proteinsKidney-derived cellsFactor familyShift assaysFactor sitesMutagenesis studiesRegulatory mechanismsMolecular mechanisms