2020
Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids
Mallick P, Song G, Efremenko A, Pendse S, Creek M, Osimitz T, Hines R, Hinderliter P, Clewell H, Lake B, Yoon M, Moreau M. Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids. Toxicological Sciences 2020, 176: 460-469. PMID: 32421774, PMCID: PMC7416317, DOI: 10.1093/toxsci/kfaa070.Peer-Reviewed Original ResearchConceptsAge-related pharmacokinetic differencesPharmacokinetic differencesPBPK modelTarget tissue exposureAge-related sensitivityHuman PBPK modelAge-dependent changesAge-related differencesRat modelTissue exposureVivo rat dataPharmacokinetic modellingPharmacokinetic modelingInternal exposureRat dataRisk assessmentVivo extrapolationRisk assessment purposesExposureAdultsExternal exposureSensitive populationsChildrenMetabolic capacityAssessment
2016
Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards
El-Masri H, Kleinstreuer N, Hines R, Adams L, Tal T, Isaacs K, Wetmore B, Tan Y. Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards. Toxicological Sciences 2016, 152: 230-243. PMID: 27208077, PMCID: PMC5009469, DOI: 10.1093/toxsci/kfw082.Peer-Reviewed Original ResearchConceptsPutative adverse outcome pathwayExposure levelsPharmacokinetic modelAdverse outcome pathwaysPotential exposure levelsFetal blood levelsExternal exposure levelsMaternal exposureBlood levelsExposure modelHigh-throughput toxicity screeningVasculogenesis/angiogenesisOutcome pathwaysPBPK modelExposure estimatesChemical dispositionDevelopmental toxicityPotential exposureVivo extrapolationExposureAdulthood stagesToxicityAssaysEnvironmental exposure modelsPregnancy
2015
Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting
Doe J, Lander D, Doerrer N, Heard N, Hines R, Lowit A, Pastoor T, Phillips R, Sargent D, Sherman J, Tanir J, Embry M. Use of the RISK21 roadmap and matrix: human health risk assessment of the use of a pyrethroid in bed netting. Critical Reviews In Toxicology 2015, 46: 54-73. PMID: 26517449, PMCID: PMC4732465, DOI: 10.3109/10408444.2015.1082974.Peer-Reviewed Original ResearchCurrent Research and Opportunities to Address Environmental Asbestos Exposures
Carlin D, Larson T, Pfau J, Gavett S, Shukla A, Miller A, Hines R. Current Research and Opportunities to Address Environmental Asbestos Exposures. Environmental Health Perspectives 2015, 123: a194-a197. PMID: 26230287, PMCID: PMC4529018, DOI: 10.1289/ehp.1409662.Peer-Reviewed Original ResearchConceptsEnvironmental asbestos exposureAsbestos exposureAsbestos-related diseasesHealth effectsRisk factorsOccupational exposureBasic research findingsDisease RegistryEnvironmental Health SciencesToxicological findingsTumor developmentSociety of ToxicologyHazardous exposuresPotential health risksDose metricsNational InstituteSusceptible populationPublic healthHigh rateAsbestosHealth risksDiseaseExposureProper dose metricToxicity