2019
A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes
Matlock M, Tambe A, Elliott-Higgins J, Hines R, Miller G, Swamidass S. A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes. Chemical Research In Toxicology 2019, 32: 1707-1721. PMID: 31304741, PMCID: PMC6933754, DOI: 10.1021/acs.chemrestox.9b00223.Peer-Reviewed Original ResearchConceptsAge-dependent changesHepatic Drug Metabolizing EnzymesAdverse drug reactionsValproic acid toxicityDrug metabolizing enzymesDrug metabolism enzymesElimination of drugsPediatric patientsPediatric populationMetabolite exposureDrug reactionsClinical dataElevated riskOverall clearanceDrug toxicityFunction of ageDrug safetyFetal periodMetabolizing enzymesDrug metabolismDrug toxicity risksPotential mechanismsAcid toxicityEnzyme expressionDemographic factors
2010
Pharmacogenetic Testing in the Pediatric Epileptic Population
Sander T, Marcuccilli C, Zembles T, Hines R, Lo S, North P. Pharmacogenetic Testing in the Pediatric Epileptic Population. The FASEB Journal 2010, 24: 568.16-568.16. DOI: 10.1096/fasebj.24.1_supplement.568.16.Peer-Reviewed Original ResearchAdverse drug reactionsAntiepileptic drugsSevere adverse drug reactionsABCB1 genetic variantsChronic neurologic disordersFast Real-Time PCR SystemRecurrent unprovoked seizuresAED therapyPediatric patientsUnprovoked seizuresADR riskDrug reactionsPhysician comfortNeurologic disordersEpileptic populationPharmacogenetic testingTherapeutic windowPharmacogenetic testsPatientsTherapeutic treatmentGenotype resultsReal-time PCR systemGenotyping assaysTherapyGenetic variants
2007
Ontogeny of human hepatic cytochromes P450
Hines R. Ontogeny of human hepatic cytochromes P450. Journal Of Biochemical And Molecular Toxicology 2007, 21: 169-175. PMID: 17936930, DOI: 10.1002/jbt.20179.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAryl Hydrocarbon HydroxylasesChildChild, PreschoolCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9Cytochrome P-450 CYP2E1Cytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHumansInfantLiverMixed Function OxygenasesConceptsHuman hepatic cytochrome P450Adverse drug reactionsConsiderable interindividual variabilityHepatic cytochrome P450Cytochrome P450Human liver samplesImportant endogenous functionsWeeks' gestationThird trimesterFirst trimesterDrug reactionsKey cytochrome P450Postnatal onsetPostnatal increaseTherapeutic efficacyInterindividual variabilityQuantitative Western blottingWestern blottingGestationLow levelsLiver samplesProbe substratesOnset of expressionTrimesterThird group
2006
Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: I. Expression and Role of Cytochromes P450
Vyas P, Roychowdhury S, Khan F, Prisinzano T, Lamba J, Schuetz E, Blaisdell J, Goldstein J, Munson K, Hines R, Svensson C. Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: I. Expression and Role of Cytochromes P450. Journal Of Pharmacology And Experimental Therapeutics 2006, 319: 488-496. PMID: 16857728, DOI: 10.1124/jpet.106.105858.Peer-Reviewed Original ResearchConceptsCutaneous drug reactionsNormal human epidermal keratinocytesEnzyme-linked immunosorbent assayDrug reactionsProtein haptenationCommon adverse drug reactionsLife-threatening complicationsAdverse drug reactionsCytochrome P450Presence of CYP3A4Immunofluorescence confocal microscopyConfocal microscopyImmune responseHuman epidermal keratinocytesNumerous minorArylamine drugsImmunosorbent assayCellular proteinsCYP2C9 proteinEpidermal keratinocytesHaptenationHuman keratinocytesChemical inhibitorsProtein adductionCyclooxygenase
2005
Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development
Koukouritaki S, Hines R. Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development. Pharmacogenomics 2005, 6: 807-822. PMID: 16296944, DOI: 10.2217/14622416.6.8.807.Peer-Reviewed Original Research