Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells
Delescluse C, Ledirac N, Li R, Piechocki M, Hines R, Gidrol X, Rahmani R. Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochemical Pharmacology 2001, 61: 399-407. PMID: 11226373, DOI: 10.1016/s0006-2952(00)00562-1.Peer-Reviewed Original ResearchMeSH KeywordsCarbarylChloramphenicol O-AcetyltransferaseCholinesterase InhibitorsCytochrome P-450 CYP1A1DNA DamageEndoplasmic Reticulum Chaperone BiPEnzyme InductionGene ExpressionHeat-Shock ProteinsHumansMutagenicity TestsOxidative StressThiabendazoleTranscription, GeneticTransfectionTumor Cells, CulturedConceptsXenobiotic responsive elementStress genesChloramphenicol acetyl transferase (CAT) reporter geneAcetyl transferase reporter geneLevel of transcriptionTransferase reporter geneOxidative stressCell linesHuman hepatoma HepG2 cell lineHuman lymphoblastoid cell linesTranscriptional regulationHepatoma HepG2 cell lineCytochrome P450 1A1 gene expressionReporter CATTranscriptional levelReporter geneXRE sequenceLymphoblastoid cell linesGene expressionFusion constructsIntracellular signalsParental linesCYP1A1 cDNAResponse elementResponsive element