2019
Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
Mallick P, Moreau M, Song G, Efremenko A, Pendse S, Creek M, Osimitz T, Hines R, Hinderliter P, Clewell H, Lake B, Yoon M. Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans. Toxicological Sciences 2019, 173: 86-99. PMID: 31593217, PMCID: PMC6944222, DOI: 10.1093/toxsci/kfz211.Peer-Reviewed Original ResearchConceptsTarget tissue exposureTissue exposurePharmacokinetic modelLiver blood flowLow internal exposureAge-related sensitivityAge-dependent changesEfficient metabolic clearanceIndividual cytochrome P450Human hepatic metabolismAge-related differencesCis-permethrinHepatic metabolismBlood flowMetabolic clearanceCES enzymesHepatic CLintInternal doseIntrinsic clearanceTarget tissuesInternal exposureClearanceCarboxylesterase enzymesCytochrome P450Vivo extrapolation
2011
Chloride Modulates GSTZ1 Haplotype‐dependent Inactivation by Dichloroacetate
Li W, Gu Y, Langaee T, Hines R, Stacpoole P, James M. Chloride Modulates GSTZ1 Haplotype‐dependent Inactivation by Dichloroacetate. The FASEB Journal 2011, 25: 813.2-813.2. DOI: 10.1096/fasebj.25.1_supplement.813.2.Peer-Reviewed Original ResearchGSTZ1 activityLiver cytosolHuman liver cytosolCongenital lactic acidosisHaplotype-dependent mannerLactic acidosisGSTZ1 protein expressionGSTZ1 haplotypeMM dichloroacetateDCA pharmacokineticsProtein expressionDichloroacetateHr incubationGSTZ1SubjectsKRTIndividualsHeterozygous individualsInactivationAcidosisPharmacokineticsCancerDosesClearance