2019
Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”
Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW. Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”. Human Genomics 2019, 13: 11. PMID: 30782214, PMCID: PMC6381713, DOI: 10.1186/s40246-019-0191-9.Peer-Reviewed Original ResearchConceptsMajor urinary protein genesKingdoms of lifeLipocalin gene familyGene familyMUP genesMouse genomeHuman genomeProtein geneChromosome 4Regulation of glucoseBarrel structurePhysiological processesΒ-strandsPhysiological functionsSecretory tissueGenesScent marksPseudogenesGenomeLipid metabolismBloomsEvidence pointsSyntenicImportant roleSteroid hormones
2015
Update of the human and mouse Fanconi anemia genes
Dong H, Nebert DW, Bruford EA, Thompson DC, Joenje H, Vasiliou V. Update of the human and mouse Fanconi anemia genes. Human Genomics 2015, 9: 32. PMID: 26596371, PMCID: PMC4657327, DOI: 10.1186/s40246-015-0054-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowDNA DamageDNA RepairEvolution, MolecularFanconi AnemiaFanconi Anemia Complementation Group ProteinsHumansMiceNeoplasmsConceptsHUGO Gene Nomenclature CommitteeDNA repair pathwaysFanconi anemiaFanconi anemia (FA) complementation group proteinsRepair pathwaysFA DNA repair pathwayCommon DNA repair pathwaySet of genesFanconi anemia genesGene Nomenclature CommitteeNumber of genesFANC genesFA pathogenesisGenomic integrityEvolutionary phylogenyGroup proteinsMutant proteinsMouse orthologRoot symbolFA pathwayPhysiological functionsGenesBone marrow failureGenetic diseasesEvolutionary perspective
2013
Update of the human and mouse SERPINgene superfamily
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V. Update of the human and mouse SERPINgene superfamily. Human Genomics 2013, 7: 22. PMID: 24172014, PMCID: PMC3880077, DOI: 10.1186/1479-7364-7-22.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEvolution, MolecularGenetic VariationHumansMiceMultigene FamilyPhylogenyProtein ConformationSerpinsConceptsHuman protein-coding genesMultiple paralogous genesProtein-coding genesParalogous genesSerine proteinase inhibitorFunctional genesSerpin geneIntracellular serpinsSerpin familyGenesProteinase inhibitorsSerpinsCancer metastasisFurther characterizationProteinTherapeutic targetChaperonesPseudogenesGenomeBlood clottingImmune functionPotential biomarkersInhibitorsTumorigenesisRole
2012
Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
Jackson BC, Holmes RS, Backos DS, Reigan P, Thompson DC, Vasiliou V. Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2. Chemico-Biological Interactions 2012, 202: 11-21. PMID: 23247008, PMCID: PMC3687035, DOI: 10.1016/j.cbi.2012.11.022.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAldehyde Dehydrogenase, MitochondrialAmino Acid SequenceAnimalsAnuraComputer SimulationEvolution, MolecularGenomicsHumansMiceModels, MolecularMolecular Sequence DataPhylogenyProtein Interaction Domains and MotifsProtein Structure, TertiarySequence AlignmentConceptsMitochondrial enzymesGenomes of birdsRepresentative vertebrate speciesProtein-protein interactionsAmino acid sequenceVertebrate genomesComparative genomicsMolecular evolutionALDH2 geneEarly vertebratesVertebrate speciesPhylogenetic analysisBioinformatics analysisAcid sequenceMammalian speciesSubunit sequencesBiological aldehydesHuman ALDH2Coenzyme bindingInactivating mutationALDH2 mutantGenesALDH1B1HeterotetramerizationGenome
2011
Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily
Jackson BC, Thompson DC, Wright MW, McAndrews M, Bernard A, Nebert DW, Vasiliou V. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. Human Genomics 2011, 5: 691. PMID: 22155607, PMCID: PMC3251818, DOI: 10.1186/1479-7364-5-6-691.Peer-Reviewed Original ResearchConceptsGene familyLarge gene familyNovel drug targetsMammalian lineagesProtein geneMammalian secretionsDrug targetsGenesMate selectionProteinSecretoglobinTissue repairBloomsBiological activityFamilyAndrogen-binding proteinPseudogenesHuman healthImportant roleModulation of inflammationLineagesSalivary glandsRoleTumorigenesisBetter understandingUpdate on the aldehyde dehydrogenase gene (ALDH) superfamily
Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V. Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Human Genomics 2011, 5: 283. PMID: 21712190, PMCID: PMC3392178, DOI: 10.1186/1479-7364-5-4-283.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAnimalsComputational BiologyEvolution, MolecularHumansMultigene FamilyPhylogenySequence Analysis, DNAConceptsAldehyde dehydrogenase geneALDH genesDehydrogenase geneALDH family membersGene loss eventsBiotechnology Information gene databaseGamma-hydroxybutyric aciduriaWhole-genome sequencingCellular processesHuman genomeEnzymic detoxificationGene databaseExogenous aldehydesProtein sequencingType II hyperprolinaemiaCancer stem cellsEntire complementMolecular basisALDH enzymesGenesFamily membersStem cellsAldehyde metabolismRetinoic acidSjögren-Larsson syndrome
2010
Evolutionary divergence and functions of the human interleukin (IL) gene family
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human interleukin (IL) gene family. Human Genomics 2010, 5: 30. PMID: 21106488, PMCID: PMC3390169, DOI: 10.1186/1479-7364-5-1-30.Peer-Reviewed Original ResearchMeSH KeywordsCluster AnalysisCytokinesEvolution, MolecularHumansInterleukinsMultigene FamilyPhylogenyProtein ConformationTerminology as TopicConceptsHelical cytokinesCell typesAmino acid conservationEvolutionary divergenceOrthologous proteinsEvolutionary relationshipsGene familyImmune cell differentiationCommon structural motifBiological functionsCell differentiationUnique structural featuresExact functionStructural featuresGroup of cytokinesMajor groupsCell proliferationImportant roleImmune systemReceptor-binding propertiesHost immune systemStructural motifsStructural informationContinual competitionNumber of interleukin