Human ALDH1B1 Polymorphisms may Affect the Metabolism of Acetaldehyde and All-trans retinaldehyde—In Vitro Studies and Computational Modeling
Jackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V. Human ALDH1B1 Polymorphisms may Affect the Metabolism of Acetaldehyde and All-trans retinaldehyde—In Vitro Studies and Computational Modeling. Pharmaceutical Research 2014, 32: 1648-1662. PMID: 25413692, PMCID: PMC4382438, DOI: 10.1007/s11095-014-1564-3.Peer-Reviewed Original ResearchAcetaldehydeAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAldehyde Dehydrogenase, MitochondrialAldehydesAmino Acid SequenceComputer SimulationHumansModels, BiologicalModels, MolecularMolecular Sequence DataNitroglycerinPolymorphism, GeneticProtein ConformationRetinaldehydeSubstrate SpecificityAcetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers
Singh S, Arcaroli J, Thompson DC, Messersmith W, Vasiliou V. Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers. Advances In Experimental Medicine And Biology 2014, 815: 281-294. PMID: 25427913, PMCID: PMC4347404, DOI: 10.1007/978-3-319-09614-8_16.Peer-Reviewed Original ResearchConceptsPancreatic cancerColorectal cancerRetinoic acidChronic alcohol consumptionImportant risk factorCancer-related deathCancer stem cellsProgression of cancerPoor prognosisEventual prognosisRisk factorsAlcohol consumptionCancerImportant mechanistic roleTumor developmentRetinaldehyde dehydrogenasesCancer initiationPrognosisColonTumorsStem cellsProgressionBiomarkersALDH1A1Mechanistic role