2003
Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk
Zheng T, Holford T, Zahm S, Owens P, Boyle P, Zhang Y, Zhang B, Wise J, Stephenson L, Ali-Osman F. Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk. British Journal Of Cancer 2003, 88: 58-62. PMID: 12556960, PMCID: PMC2376773, DOI: 10.1038/sj.bjc.6600708.Peer-Reviewed Original ResearchConceptsBreast cancer riskGSTT1 null genotypeCancer riskAlcohol consumptionGST genotypesBreast cancerPostmenopausal womenGenetic polymorphismsIncident breast cancer patientsGlutathione S-transferase M1Breast cancer patientsT1 genetic polymorphismsCase-control studyGSTT1 genetic polymorphismsGlutathione S-transferaseS-transferase M1Cancer patientsEffect modificationGSTM1 genotypeHigh riskNew Haven CountyYounger ageCancerWomenRisk
2002
Use of hair colouring products and breast cancer risk a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Boyle P, Zhang B, Zhang Y, Zahm S. Use of hair colouring products and breast cancer risk a case–control study in Connecticut. European Journal Of Cancer 2002, 38: 1647-1652. PMID: 12142056, DOI: 10.1016/s0959-8049(02)00138-7.Peer-Reviewed Original ResearchRadiation exposure from diagnostic and therapeutic treatments and risk of breast cancer
Zheng T, Holford TR, Mayne ST, Luo J, Owens PH, Zhang B, Zhang W, Zhang Y. Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancer. European Journal Of Cancer Prevention 2002, 11: 229-235. PMID: 12131656, DOI: 10.1097/00008469-200206000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreast NeoplasmsCase-Control StudiesFemaleHumansNeoplasms, Radiation-InducedRisk FactorsConceptsBreast cancerTherapeutic radiation treatmentRadiation treatmentOdds ratioTherapeutic radiationSkin problemsBreast cancer risk factorsRadiation exposureCancer risk factorsBreast cancer riskCase-control studyDiagnostic X-ray exposurePostmenopausal womenRisk factorsCancer riskHigh riskYounger ageTherapeutic treatmentCancerDiagnostic X-raysPerson interviewsTreatmentX-ray exposureRiskStructured questionnaireA case-control study of occupation and breast-cancer risk in Connecticut.
Zheng T, Holford T, Taylor Mayne S, Luo J, Hansen Owens P, Hoar Zahm S, Zhang B, Zhang Y, Zhang W, Jiang Y, Boyle P. A case-control study of occupation and breast-cancer risk in Connecticut. Journal Of Cancer Epidemiology And Prevention 2002, 7: 3-11. PMID: 12369604, DOI: 10.1080/14766650252962621.Peer-Reviewed Original Research
2001
Lactation and breast cancer risk: a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Zhang Y, Zhang B, Boyle P, Zahm S. Lactation and breast cancer risk: a case–control study in Connecticut. British Journal Of Cancer 2001, 84: 1472-1476. PMID: 11384096, PMCID: PMC2363665, DOI: 10.1054/bjoc.2001.1793.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskIncident breast cancer casesMajor risk factorCase-control studyBreast cancer casesRisk reductionMenopausal statusParous womenPostmenopausal womenInverse associationRisk factorsCancer casesStudy interviewersFurther stratificationFirst childWomenStructured questionnaireLifetime durationCancerRiskLactationChildrenBreastfeeding1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies
Laden F, Collman G, Iwamoto K, Alberg A, Berkowitz G, Freudenheim J, Hankinson S, Helzlsouer K, Holford T, Huang H, Moysich K, Tessari J, Wolff M, Zheng T, Hunter D. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies. Journal Of The National Cancer Institute 2001, 93: 768-775. PMID: 11353787, DOI: 10.1093/jnci/93.10.768.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskRisk factorsEffect modificationOdds ratioBreast cancer risk factorsElevated breast cancer riskAssess effect modificationBody mass indexCancer risk factorsConfidence intervalsPooled odds ratioPotential risk factorsPlasma/serum concentrationsAssociation of levelsLarge U.S. studiesRandom-effects modelCase patientsMass indexMiddle tertileFifth quintilePooled analysisControl subjectsSerum concentrations
2000
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk
Holford T, Zheng T, Mayne S, Zahm S, Tessari J, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. International Journal Of Epidemiology 2000, 29: 975-982. PMID: 11101537, DOI: 10.1093/ije/29.6.975.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskProtective effectBreast adipose tissue samplesYale-New Haven HospitalBreast-related surgeryAdipose tissue samplesStandardized questionnaireHealth concernCYP2B inducersAdverse effectsLogistic ridge regressionTissue samplesExposure levelsSignificant differencesMajor environmental health concernRiskEnvironmental health concernsPCB congenersDioxin-like congenersJoint effectsPatientsStatistical analysisSurgeryRegressionBreast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls
Zheng T, Holford TR, Tessari J, Mayne ST, Owens PH, Ward B, Carter D, Boyle P, Dubrow R, Archibeque-Engle S, Zahm SH. Breast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls. American Journal Of Epidemiology 2000, 152: 50-58. PMID: 10901329, DOI: 10.1093/aje/152.1.50.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAgedBreast NeoplasmsCase-Control StudiesFemaleHumansMiddle AgedPolychlorinated BiphenylsRisk FactorsConceptsBreast cancer riskCancer riskCovariate-adjusted odds ratioBreast Cancer Risk AssociatedCase-control studyBreast cancer casesBreast adipose tissueMean tissue levelsCancer Risk AssociatedLowest tertileThird tertileBreast diseaseOdds ratioBreast cancerCancer casesConnecticut womenAdipose tissueFurther stratificationSignificant associationStudy participantsTissue levelsNonhormonal activitiesBody levelEnvironmental exposuresSpecific PCB congenersExposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk
Zheng T, Holford T, Mayne S, Owens P, Zhang B, Boyle P, Carter D, Ward B, Zhang Y, Zahm S. Exposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk. American Journal Of Epidemiology 2000, 151: 1103-1111. PMID: 10873135, DOI: 10.1093/oxfordjournals.aje.a010154.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskOdds ratioAge frequency-matched controlsIncident breast cancer patientsElectric blanketFrequency-matched controlsAdjusted odds ratioBreast cancer patientsEstrogen receptor statusFemale breast cancerCase-control studyDuration of useReceptor statusCancer patientsNever usersBreast cancerStudy interviewersRegular useLifetime useRiskStructured questionnaireExposureTotalOxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer.
Zheng T, Holford T, Tessari J, Mayne S, Zahm S, Owens P, Zhang B, Ward B, Carter D, Zhang Y, Zhang W, Dubrow R, Boyle P. Oxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer. Journal Of Cancer Epidemiology And Prevention 2000, 5: 153-60. PMID: 11051111.Peer-Reviewed Original ResearchConceptsAdipose tissue levelsBreast cancer riskFemale breast cancerBreast adipose tissueBreast cancerRisk factorsOdds ratioAdipose tissueBenign breast disease controlsFemale breast cancer riskPrimary breast cancer patientsCovariate-adjusted odds ratioEnvironmental exposuresProgesterone receptor statusBreast cancer patientsRecent epidemiological studiesMenopausal statusReceptor statusHighest quartileEpidemiological studiesCancerMajor metaboliteRiskStructured questionnaireOverall significant impact
1999
DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer
Zheng T, Holford T, Mayne S, Ward B, Carter D, Ownes P, Dubrow R, Zahm S, Boyle P, Archibeque S, Tessari J. DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer. American Journal Of Epidemiology 1999, 150: 453-458. PMID: 10472944, DOI: 10.1093/oxfordjournals.aje.a010033.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast adipose tissueTissue levelsCancer riskAdipose tissueBenign breast disease controlsIncident breast cancer casesYale-New Haven HospitalBreast-related surgeryAdipose tissue levelsFemale breast cancerCase-control studyBreast cancer casesMean tissue levelsLogistic regression modelsRank sum testHighest quartileSurgical specimenDichlorodiphenyltrichloroethane (DDT) exposureOdds ratioBreast cancerCancer casesDisease controlSum testMean levelsβ‐Benzene hexachloride in breast adipose tissue and risk of breast carcinoma
Zheng T, Holford T, Mayne S, Owens P, Ward B, Carter D, Dubrow R, Zahm S, Boyle P, Tessari J. β‐Benzene hexachloride in breast adipose tissue and risk of breast carcinoma. Cancer 1999, 85: 2212-2218. PMID: 10326700, DOI: 10.1002/(sici)1097-0142(19990515)85:10<2212::aid-cncr16>3.0.co;2-f.Peer-Reviewed Original ResearchConceptsBreast adipose tissueAdipose tissue levelsBreast carcinoma riskBreast carcinoma casesBreast carcinomaAdipose tissueCarcinoma casesCarcinoma riskTissue levelsBenign breast diseaseProgesterone receptor statusPatients age 40Association of exposurePrimary breast carcinomaLogistic regression modelsPostmenopausal womenMenopausal statusParous womenNulliparous womenReceptor statusHighest quartilePotential confoundersBreast diseaseΒ-benzene hexachlorideConnecticut women
1997
Time trend of female breast carcinoma In Situ by race and histology in Connecticut, U.S.A.
Zheng T, Holford T, Chen Y, Jones B, Flannery J, Boyle P. Time trend of female breast carcinoma In Situ by race and histology in Connecticut, U.S.A. European Journal Of Cancer 1997, 33: 96-100. PMID: 9071907, DOI: 10.1016/s0959-8049(96)00371-1.Peer-Reviewed Original ResearchConceptsAge-adjusted incidence ratesSitu breast cancerFemale breast carcinomaIncidence rateBreast cancerMammography screeningBreast carcinomaOverall age-adjusted incidence rateAge group 40 yearsAge groupsEarly-stage breast cancerAge-specific incidence ratesFemale breast cancer incidenceConnecticut Tumor RegistryBreast cancer incidenceStage breast cancerEfficacy of mammographyFemale breast cancerAge group 40Older age groupsTime trendsTumor RegistryIncident casesDuctal carcinomaCancer incidence
1992
Risk Factors Predicting the Incidence of Second Primary Breast Cancer among Women Diagnosed with a First Primary Breast Cancer*
Bernstein J, Thompson W, Risch N, Holford T. Risk Factors Predicting the Incidence of Second Primary Breast Cancer among Women Diagnosed with a First Primary Breast Cancer*. American Journal Of Epidemiology 1992, 136: 925-936. PMID: 1456269, DOI: 10.1093/oxfordjournals.aje.a116565.Peer-Reviewed Original ResearchConceptsFirst primary breast cancerPrimary breast cancerSecond primary breast cancerContralateral breast cancerBreast cancerRisk factorsInitial tumorIncidence rateFirst primaryFirst prospective cohort studyAge-specific incidence ratesDirect patient interviewProspective cohort studySteroid Hormone StudySecond breast cancerEnd Results ProgramBenign breast biopsyProportional hazards modelSpecific risk factorsCohort studyTumor characteristicsLobular carcinomaResults ProgramPatient interviewsTreatment modalitiesThe Genetic Epidemiology of Second Primary Breast Cancer*
Bernstein J, Thompson W, Risch N, Holford T. The Genetic Epidemiology of Second Primary Breast Cancer*. American Journal Of Epidemiology 1992, 136: 937-948. PMID: 1456270, DOI: 10.1093/oxfordjournals.aje.a116566.Peer-Reviewed Original ResearchConceptsSecond primary breast cancerPrimary breast cancerContralateral breast cancerFirst primary breast cancerFirst-degree relativesBreast cancerFamily historyOvarian cancerMulti-center population-based case-control studyPopulation-based case-control studyAge-adjusted rate ratioSteroid Hormone StudyBilateral breast cancerEnd Results ProgramRate ratioCase-control studyCorresponding rate ratiosContralateral breastEndometrial cancerProspective studyResults ProgramSecond primaryCohort membersHigh riskHormone Study
1991
Trends in female breast cancer in Connecticut and the United States
Holford T, Roush G, McKay L. Trends in female breast cancer in Connecticut and the United States. Journal Of Clinical Epidemiology 1991, 44: 29-39. PMID: 1986055, DOI: 10.1016/0895-4356(91)90198-i.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsBreast NeoplasmsCohort StudiesConnecticutFemaleHumansIncidenceMenopauseUnited StatesConceptsBreast cancer mortalityBirth-cohort patternFemale breast cancerBreast cancerCancer mortalityCohort patternsPostmenopausal breast cancerInvasive breast cancerBlind biopsyBirth cohortMortalityCancerCohort modelingEarly detectionPrior reportsImproved treatmentTime trendsCohortU.S. mortalityModest declineLittle evidenceImportant differencesBiopsyIncidenceUnderdetection
1985
Risk Factors for Fibrocystic Breast Disease and Its Histopathologic Components2
Berkowitz G, Kelsey J, LiVolsi V, Holford T, Merino M, Ort S, O'Connor T, White C. Risk Factors for Fibrocystic Breast Disease and Its Histopathologic Components2. Journal Of The National Cancer Institute 1985, 75: 43-50. PMID: 3859695, DOI: 10.1093/jnci/75.1.43.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseBenign breast diseaseBreast diseaseHigher socioeconomic statusOdds ratioLow Quetelet's indexSocioeconomic statusBreast cancer patientsCase-control studyEpidemiologic similaritiesCurrent smokersPostmenopausal womenPremenopausal womenEpithelial atypiaGross cystsFibrocystic diseaseCancer patientsPapillary hyperplasiaQuetelet indexBiopsy specimensRisk factorsSurgical conditionsConnecticut hospitalsLow parityBreast cancerAN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA
PASTIDES H, KELSEY J, HOLFORD T, LIVOLSI V. AN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA. American Journal Of Epidemiology 1985, 121: 440-447. PMID: 4014134, DOI: 10.1093/oxfordjournals.aje.a114016.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseDuctal epithelial atypiaCase-control studyBreast diseaseDuctal atypiaEpithelial atypiaMinimal atypiaBreast cancerFirst-degree female relativesBreast biopsy specimensRecent checkupSurgical menopauseEpidemiologic characteristicsFirst pregnancyBiopsy specimensRisk factorsEpidemiologic studiesAtypiaCheckupAtypia scoreFrequent checkupsBreast lesionsDiseaseFemale relativesOnly variable
1982
Effect of age at first childbirth on risk of developing specific histologic subtype of breast cancer
Livolsi V, Kelsey J, Fischer D, Holford T, Mostow E, Goldenberg I. Effect of age at first childbirth on risk of developing specific histologic subtype of breast cancer. Cancer 1982, 49: 1937-1940. PMID: 6280850, DOI: 10.1002/1097-0142(19820501)49:9<1937::aid-cncr2820490931>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsBreast cancerRisk factorsHistologic subtypeLobular carcinomaSpecific histologic subtypesBenign breast diseaseBreast cancer riskCase-control studyFirst childLater ageVariety of cancersPostmenopausal womenDuct cancerEffect of ageNulliparous womenDuctal carcinomaHistopathologic subtypeEpidemiologic variablesLobular tumorsBreast diseaseBreast carcinomaFamily historyCancer riskBody weightComparison women
1979
Fibroadenoma in oral contraceptive users. A histopathologic evaluation of epithelial atypia
Livolsi V, Stadel B, Kelsey J, Holford T. Fibroadenoma in oral contraceptive users. A histopathologic evaluation of epithelial atypia. Cancer 1979, 44: 1778-1781. PMID: 498048, DOI: 10.1002/1097-0142(197911)44:5<1778::aid-cncr2820440535>3.0.co;2-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenofibromaAdultBreast NeoplasmsContraceptives, OralEpitheliumFemaleFibrocystic Breast DiseaseHumansRiskConceptsEpithelial atypiaLong-term usersOral contraceptivesOral contraceptive useOral contraceptive usersFibrocystic diseaseHistopathologic evaluationBreast diseaseContraceptive usersCytologic atypiaContraceptive useEpithelial componentAtypiaEpidemiological investigationsFibroadenomaDiseaseContraceptives