2023
Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda
Saarman N, Son J, Zhao H, Cosme L, Kong Y, Li M, Wang S, Weiss B, Echodu R, Opiro R, Aksoy S, Caccone A. Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda. Infection Genetics And Evolution 2023, 114: 105501. PMID: 37709241, PMCID: PMC10593118, DOI: 10.1016/j.meegid.2023.105501.Peer-Reviewed Original ResearchConceptsGenome-wide association analysisNovel vector control strategiesAnimal African trypanosomiasisSex chromosome aneuploidyNatural populationsGenome assemblySex chromosomesGenomic regionsGenomic evidenceGenetic variationBp upstreamAutosomal SNPsSeq dataTrypanosome infectionTrypanosome parasitesAssociation analysisMolecular pathwaysAssembly metricsLinkage disequilibriumLecithin-cholesterol acyltransferaseAfrican trypanosomiasisMajor vectorGenomeSNPsPrimary vectorMicrobiota in disease-transmitting vectors
Wang J, Gao L, Aksoy S. Microbiota in disease-transmitting vectors. Nature Reviews Microbiology 2023, 21: 604-618. PMID: 37217793, DOI: 10.1038/s41579-023-00901-6.Peer-Reviewed Original ResearchConceptsSymbiotic associationVector-borne diseasesDisease-transmitting vectorsAlternative control methodsVector competenceUnique key featuresHealth of humansSymbiotic microorganismsVector taxaReproductive strategiesArthropod hostsLife historyVector arthropodsHaematophagous arthropodsTriatomine bugsBlood feedVector populationsTransmission successArthropodsFeeding behaviorCurrent knowledgeMicrobiotaPathogensKnowledge gapsTaxa
2020
Vector-borne Zoonotic Diseases in Turkey: Rising Threats on Public Health
Düzlü Ö, İnci A, Yıldırım A, Doğanay M, Özbel Y, Aksoy S. Vector-borne Zoonotic Diseases in Turkey: Rising Threats on Public Health. Turkish Journal Of Parasitology 2020, 44: 168-175. PMID: 32928726, DOI: 10.4274/tpd.galenos.2020.6985.Peer-Reviewed Original ResearchConceptsVector-borne zoonotic diseasePublic healthZoonotic diseaseRe-emerging arbovirusWorld Health OrganizationSuch infectionsZoonotic infectionMosquito-borneArthropod speciesDiseaseHabitat featuresHealth OrganizationPathogen transmission patternsAlarming increaseClimate-related changesFly-borne diseasesGlobal healthInfectionHealthMigratory patternsNew control programsAnimal welfareFuture control effortsTransmission patternsControl programsSingle-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens
Vigneron A, O'Neill MB, Weiss BL, Savage AF, Campbell OC, Kamhawi S, Valenzuela JG, Aksoy S. Single-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 2613-2621. PMID: 31964820, PMCID: PMC7007551, DOI: 10.1073/pnas.1914423117.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingRNA sequencingInfectious metacyclic formsMetacyclic parasitesMammalian host environmentFly salivary glandsMajor cell clustersClustering of cellsTsetse salivary glandsFamily proteinsDevelopmental programMammalian hostsMetacyclic cellsProtein transcriptsTrypanosoma bruceiDevelopmental processesGene expressionAfrican trypanosomesExpression profilesMolecular mechanismsSalivary glandsNew hostSurface localizationTrypanosome transmissionMetacyclogenesis
2019
Colonization of the tsetse fly midgut with commensal Kosakonia cowanii Zambiae inhibits trypanosome infection establishment
Weiss BL, Maltz MA, Vigneron A, Wu Y, Walter KS, O’Neill M, Wang J, Aksoy S. Colonization of the tsetse fly midgut with commensal Kosakonia cowanii Zambiae inhibits trypanosome infection establishment. PLOS Pathogens 2019, 15: e1007470. PMID: 30817773, PMCID: PMC6394900, DOI: 10.1371/journal.ppat.1007470.Peer-Reviewed Original ResearchConceptsRefractory phenotypeEnormous socio-economic burdenWild-type counterpartsInfection establishmentSocio-economic burdenMidgut environmentEntomopathogenic Serratia marcescensEndemic regionsPathogenic trypanosomesInfectionStable infectionAdverse effectsAnimal African trypanosomiasesVector competenceGutCurrent disease control strategiesSaharan AfricaDisease control strategiesSurvivalSerratia marcescensTsetse gutExogenous bacteriumFly survivalNovel strategyPhenotype
2017
Human African trypanosomiasis control: Achievements and challenges
Aksoy S, Buscher P, Lehane M, Solano P, Van Den Abbeele J. Human African trypanosomiasis control: Achievements and challenges. PLOS Neglected Tropical Diseases 2017, 11: e0005454. PMID: 28426685, PMCID: PMC5398477, DOI: 10.1371/journal.pntd.0005454.Peer-Reviewed Original Research
2016
Mammalian African trypanosome VSG coat enhances tsetse’s vector competence
Aksoy E, Vigneron A, Bing X, Zhao X, O'Neill M, Wu YN, Bangs JD, Weiss BL, Aksoy S. Mammalian African trypanosome VSG coat enhances tsetse’s vector competence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 6961-6966. PMID: 27185908, PMCID: PMC4922192, DOI: 10.1073/pnas.1600304113.Peer-Reviewed Original ResearchConceptsVariant surface glycoproteinPeritrophic matrixMammalian hostsVector competenceTranscription factor familyMidgut homeostasisTsetse midgutTrypanosome biologyFactor familyPM barrierCoat proteinNovel functionAfrican trypanosomesTsetse vectorInfection processParasite developmentAnimal trypanosomiasesAntigenic variationVSG moleculesVSG coatBiological vectorsMidgutProtozoan parasiteDisease transmissionTsetse flies
2001
Prospects for control of African trypanosomiasis by tsetse vector manipulation
Aksoy S, O'Neill S, Maudlin I, Dale C, Robinson A. Prospects for control of African trypanosomiasis by tsetse vector manipulation. Trends In Parasitology 2001, 17: 29-35. PMID: 11137738, DOI: 10.1016/s1471-4922(00)01850-x.Peer-Reviewed Original ResearchConceptsArea-wide approachHuman disease managementLivestock ownersAnimal diseasesAgricultural outputMolecular genetic approachesImportant insectsInfected hostDisease managementEconomic incentivesTsetse populationsVector manipulationGenetic approachesMammalian hostsVector competenceEffective vaccineDiseases reliesHostTrypanosomiasisControl strategyInsectsAfrican trypanosomiasisTsetseLong runControl
1999
Sandflies (Diptera: Psychodidae) Associated with Epidemic Cutaneous Leishmaniasis in Sanliurfa, Turkey
Alptekin D, Kasap M, Luleyap U, Kasap H, Aksoy S, Wilson M. Sandflies (Diptera: Psychodidae) Associated with Epidemic Cutaneous Leishmaniasis in Sanliurfa, Turkey. Journal Of Medical Entomology 1999, 36: 277-281. PMID: 10337097, DOI: 10.1093/jmedent/36.3.277.Peer-Reviewed Original Research
1995
The GAP Project in Southeastern Turkey: The Potential for Emergence of Diseases - Volume 1, Number 2—April 1995 - Emerging Infectious Diseases journal - CDC
Aksoy S, Ariturk S, Armstrong M, Chang K, Dörtbudak Z, Gottlieb M, Ozcel M, Richards F, Western K. The GAP Project in Southeastern Turkey: The Potential for Emergence of Diseases - Volume 1, Number 2—April 1995 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 1995, 1: 62-63. PMID: 8903163, PMCID: PMC2626833, DOI: 10.3201/eid0102.950207.Peer-Reviewed Original Research