2023
Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda
Saarman N, Son J, Zhao H, Cosme L, Kong Y, Li M, Wang S, Weiss B, Echodu R, Opiro R, Aksoy S, Caccone A. Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda. Infection Genetics And Evolution 2023, 114: 105501. PMID: 37709241, PMCID: PMC10593118, DOI: 10.1016/j.meegid.2023.105501.Peer-Reviewed Original ResearchConceptsGenome-wide association analysisNovel vector control strategiesAnimal African trypanosomiasisSex chromosome aneuploidyNatural populationsGenome assemblySex chromosomesGenomic regionsGenomic evidenceGenetic variationBp upstreamAutosomal SNPsSeq dataTrypanosome infectionTrypanosome parasitesAssociation analysisMolecular pathwaysAssembly metricsLinkage disequilibriumLecithin-cholesterol acyltransferaseAfrican trypanosomiasisMajor vectorGenomeSNPsPrimary vector
2021
Viviparity and habitat restrictions may influence the evolution of male reproductive genes in tsetse fly (Glossina) species
Savini G, Scolari F, Ometto L, Rota-Stabelli O, Carraretto D, Gomulski LM, Gasperi G, Abd-Alla AMM, Aksoy S, Attardo GM, Malacrida AR. Viviparity and habitat restrictions may influence the evolution of male reproductive genes in tsetse fly (Glossina) species. BMC Biology 2021, 19: 211. PMID: 34556101, PMCID: PMC8461966, DOI: 10.1186/s12915-021-01148-4.Peer-Reviewed Original ResearchConceptsMale reproductive genesReproductive genesSelective pressureHabitat restrictionLong evolutionary time scalesFunctional selective pressuresPost-zygotic isolationComparative genomics approachReproductive behaviorEvolutionary time scalesUnique reproductive strategyLong evolutionary historyStrong selective pressureDivergent demographic historiesMale reproductive biologyTsetse fly speciesGenomic conflictAdenotrophic viviparityParental genomesGenomic approachesAllopatric distributionsEvolutionary historyDemographic historyReproductive biologyEvolutionary tree
2019
Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Attardo GM, Abd-Alla AMM, Acosta-Serrano A, Allen JE, Bateta R, Benoit JB, Bourtzis K, Caers J, Caljon G, Christensen MB, Farrow DW, Friedrich M, Hua-Van A, Jennings EC, Larkin DM, Lawson D, Lehane MJ, Lenis VP, Lowy-Gallego E, Macharia RW, Malacrida AR, Marco HG, Masiga D, Maslen GL, Matetovici I, Meisel RP, Meki I, Michalkova V, Miller WJ, Minx P, Mireji PO, Ometto L, Parker AG, Rio R, Rose C, Rosendale AJ, Rota-Stabelli O, Savini G, Schoofs L, Scolari F, Swain MT, Takáč P, Tomlinson C, Tsiamis G, Van Den Abbeele J, Vigneron A, Wang J, Warren WC, Waterhouse RM, Weirauch MT, Weiss BL, Wilson RK, Zhao X, Aksoy S. Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes. Genome Biology 2019, 20: 187. PMID: 31477173, PMCID: PMC6721284, DOI: 10.1186/s13059-019-1768-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA Transposable ElementsDrosophila melanogasterFemaleGene Expression RegulationGenes, InsectGenes, X-LinkedGenome, InsectGenomicsGeographyInsect ProteinsInsect VectorsMaleMutagenesis, InsertionalPhylogenyRepetitive Sequences, Nucleic AcidSequence Homology, Amino AcidSyntenyTrypanosomaTsetse FliesWolbachiaConceptsFemale-specific gene expressionMale seminal proteinsSex-linked scaffoldsComparative genomic analysisLow evolutionary ratesVectors of humanSyntenic analysisEvolutionary ratesNovel pestsEvolutionary relationshipsBacterial symbiosisGustatory genesEvolutionary biologyHelicase activityStructural conservationDifferent habitatsSeminal proteinsGenomic analysisHost preferenceX chromosomeDisease control strategiesUnique adaptationsGene expressionAfrican trypanosomesRhodopsin gene
2018
A fine-tuned vector-parasite dialogue in tsetse's cardia determines peritrophic matrix integrity and trypanosome transmission success
Vigneron A, Aksoy E, Weiss BL, Bing X, Zhao X, Awuoche EO, O'Neill MB, Wu Y, Attardo GM, Aksoy S. A fine-tuned vector-parasite dialogue in tsetse's cardia determines peritrophic matrix integrity and trypanosome transmission success. PLOS Pathogens 2018, 14: e1006972. PMID: 29614112, PMCID: PMC5898766, DOI: 10.1371/journal.ppat.1006972.Peer-Reviewed Original Research
2014
Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis
Initiative I, Attardo G, Abila P, Auma J, Baumann A, Benoit J, Brelsfoard C, Ribeiro J, Cotton J, Pham D, Darby A, Van Den Abbeele J, Denlinger D, Field L, Nyanjom S, Gaunt M, Geiser D, Gomulski L, Haines L, Hansen I, Jones J, Kibet C, Kinyua J, Larkin D, Lehane M, Rio R, Macdonald S, Macharia R, Malacrida A, Marco H, Marucha K, Masiga D, Meuti M, Mireji P, Obiero G, Koekemoer J, Okoro C, Omedo I, Osamor V, Balyeidhusa A, Peyton J, Price D, Quail M, Ramphul U, Rawlings N, Riehle M, Robertson H, Sanders M, Scott M, Dashti Z, Snyder A, Srivastava T, Stanley E, Swain M, Hughes D, Tarone A, Taylor T, Telleria E, Thomas G, Walshe D, Wilson R, Winzerling J, Acosta-Serrano A, Aksoy S, Arensburger P, Aslett M, Bateta R, Benkahla A, Berriman M, Bourtzis K, Caers J, Caljon G, Christoffels A, Falchetto M, Friedrich M, Fu S, Gäde G, Githinji G, Gregory R, Hall N, Harkins G, Hattori M, Hertz-Fowler C, Hide W, Hu W, Imanishi T, Inoue N, Jonas M, Kawahara Y, Koffi M, Kruger A, Lawson D, Lehane S, Lehväslaiho H, Luiz T, Makgamathe M, Malele I, Manangwa O, Manga L, Megy K, Michalkova V, Mpondo F, Mramba F, Msangi A, Mulder N, Murilla G, Mwangi S, Okedi L, Ommeh S, Ooi C, Ouma J, Panji S, Ravel S, Rose C, Sakate R, Schoofs L, Scolari F, Sharma V, Sim C, Siwo G, Solano P, Stephens D, Suzuki Y, Sze S, Touré Y, Toyoda A, Tsiamis G, Tu Z, Wamalwa M, Wamwiri F, Wang J, Warren W, Watanabe J, Weiss B, Willis J, Wincker P, Zhang Q, Zhou J. Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis. Science 2014, 344: 380-386. PMID: 24763584, PMCID: PMC4077534, DOI: 10.1126/science.1249656.Peer-Reviewed Original ResearchConceptsGenome sequenceLactation-specific proteinsProtein-encoding genesBacterial genome sequencesPathogen recognition proteinsTsetse fliesMicrobial symbiosesTsetse biologyViviparous reproductionGenome dataRecognition proteinsSole vectorsChromosomal integrationDisease vectorsAfrican trypanosomiasisGenomeGenesFliesProteinSequenceMultiple aspectsHuman African trypanosomiasisImportant insightsMultiple discoveriesSymbioses
2009
Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission
Wang J, Wu Y, Yang G, Aksoy S. Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 12133-12138. PMID: 19587241, PMCID: PMC2715537, DOI: 10.1073/pnas.0901226106.Peer-Reviewed Original ResearchConceptsImmune deficiencyPGRP-LBHost immune responsePeptidoglycan recognition proteinsAnti-protozoal activityTsetse's abilityImmune responseInfection susceptibilityHost immunityExpression correlatesNormal adultsInfectionHost susceptibilityAntimicrobial peptidesParasitized adultsTrypanosome infectionAdult tsetseRecognition proteinsLimited exposureAdultsForeign microbesRNA interferencePathway functionActivationSusceptibility
1992
Spliced leader RNA sequences of Trypanosoma rangeli are organized within the 5S rRNA-encoding genes
Aksoy S, Shay G, Villaneuva M, Beard C, Richards F. Spliced leader RNA sequences of Trypanosoma rangeli are organized within the 5S rRNA-encoding genes. Gene 1992, 113: 239-243. PMID: 1572544, DOI: 10.1016/0378-1119(92)90401-a.Peer-Reviewed Original Research