2022
Microbe Profile: Wigglesworthia glossinidia: the tsetse fly’s significant other
Weiss BL, Rio RVM, Aksoy S. Microbe Profile: Wigglesworthia glossinidia: the tsetse fly’s significant other. Microbiology 2022, 168: 001242. PMID: 36129743, PMCID: PMC10723186, DOI: 10.1099/mic.0.001242.Peer-Reviewed Original ResearchConceptsPhysiological homeostasisNutritional roleEssential nutritional roleUnique physiological adaptationsTsetse fliesFly microbiotaWigglesworthia glossinidiaObligate mutualistsHost fitnessAncient associationParasitic trypanosomesLarval periodPhysiological adaptationsFitness outcomesTsetse's abilityAntimicrobial responsesImmune systemAmidasesFliesMicrobiotaMutualistsWigglesworthiaEndosymbiontsGenomeB vitamins
2009
Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission
Wang J, Wu Y, Yang G, Aksoy S. Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 12133-12138. PMID: 19587241, PMCID: PMC2715537, DOI: 10.1073/pnas.0901226106.Peer-Reviewed Original ResearchConceptsImmune deficiencyPGRP-LBHost immune responsePeptidoglycan recognition proteinsAnti-protozoal activityTsetse's abilityImmune responseInfection susceptibilityHost immunityExpression correlatesNormal adultsInfectionHost susceptibilityAntimicrobial peptidesParasitized adultsTrypanosome infectionAdult tsetseRecognition proteinsLimited exposureAdultsForeign microbesRNA interferencePathway functionActivationSusceptibility