2017
Unravelling the relationship between the tsetse fly and its obligate symbiont Wigglesworthia: transcriptomic and metabolomic landscapes reveal highly integrated physiological networks
Bing X, Attardo GM, Vigneron A, Aksoy E, Scolari F, Malacrida A, Weiss BL, Aksoy S. Unravelling the relationship between the tsetse fly and its obligate symbiont Wigglesworthia: transcriptomic and metabolomic landscapes reveal highly integrated physiological networks. Proceedings Of The Royal Society B 2017, 284: 20170360. PMID: 28659447, PMCID: PMC5489720, DOI: 10.1098/rspb.2017.0360.Peer-Reviewed Original ResearchConceptsPeptidoglycan recognition proteinsAfrican trypanosome parasitesTsetse fliesAmino acid metabolismWigglesworthia glossinidiaMultiple metabolic pathwaysObligate endosymbiontsMolecular chaperonesTransport machineryVertebrate bloodMetabolomic landscapeRecognition proteinsSeq analysisSymbiotic dialogueNucleotide biosynthesisAdenosyl methionineBiological functionsSpecialized cellsTsetse survivalTrypanosome parasitesEssential cofactorMetabolic pathwaysNew biological targetsAcid metabolismPhysiological networks
2012
PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring
Wang J, Aksoy S. PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 10552-10557. PMID: 22689989, PMCID: PMC3387098, DOI: 10.1073/pnas.1116431109.Peer-Reviewed Original ResearchConceptsMother's milkImmune deficiency (IMD) pathwayPGRP-LBHost immune systemImmune system developmentIntrauterine environmentNutritional supplementationDietary supplementationHyperimmune responseImmune systemImpact immunityNewborn progenyParasite infectionAdultsParasitized adultsPeptidoglycan recognition proteinsSuch adultsImmunitySupplementationAntitrypanosomal activityPivotal roleMilkInductionHost fecundityMilk proteins
2009
Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission
Wang J, Wu Y, Yang G, Aksoy S. Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 12133-12138. PMID: 19587241, PMCID: PMC2715537, DOI: 10.1073/pnas.0901226106.Peer-Reviewed Original ResearchConceptsImmune deficiencyPGRP-LBHost immune responsePeptidoglycan recognition proteinsAnti-protozoal activityTsetse's abilityImmune responseInfection susceptibilityHost immunityExpression correlatesNormal adultsInfectionHost susceptibilityAntimicrobial peptidesParasitized adultsTrypanosome infectionAdult tsetseRecognition proteinsLimited exposureAdultsForeign microbesRNA interferencePathway functionActivationSusceptibility