2019
Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana.
Orr AR, Quagraine JE, Suwondo P, George S, Harrison LM, Dornas FP, Evans B, Caccone A, Humphries D, Wilson MD, Cappello M. Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana. American Journal Of Tropical Medicine And Hygiene 2019, 100: 351-356. PMID: 30734697, PMCID: PMC6367626, DOI: 10.4269/ajtmh.18-0727.Peer-Reviewed Original ResearchConceptsMass drug administrationSoil-transmitted helminthsKintampo North MunicipalitySchool-aged childrenSingle nucleotide polymorphismsPolymerase chain reactionEffectiveness of MDAWild-type SNPsInfected study subjectsPeriodic mass drug administrationResistance-associated single nucleotide polymorphismsCross-sectional studyResistance-associated mutationsWorld Health OrganizationHookworm infectionDrug exposureHookworm eggsUnreported associationStudy subjectsDrug AdministrationPosttreatment samplesChemotherapeutic approachesGrowth delayHuman hookwormHealth Organization
2014
Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana
Kotze AC, Dobson RJ, Humphries D, Wilson M, Cappello M. Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana. International Journal For Parasitology Drugs And Drug Resistance 2014, 4: 64-70. PMID: 24596670, PMCID: PMC3940077, DOI: 10.1016/j.ijpddr.2014.01.001.Peer-Reviewed Original ResearchDrug treatmentFaecal egg count reduction testDrug efficacyPre-treatment samplesDrug treatment studiesOverall drug efficacyStudy subjectsSignificant prevalenceEgg excretionPoisson distribution analysisTreatment studiesEfficacySignificant increaseEgg count reduction testSubjectsTreatmentControl measuresSuch subjectsReduction testStoolCasesPoisson distribution methodExcretionPrevalenceQuality control measures