2008
Continuous infusion versus intermittent bolus doses of indomethacin for patent ductus arteriosus closure in symptomatic preterm infants
Görk A, Ehrenkranz R, Bracken M. Continuous infusion versus intermittent bolus doses of indomethacin for patent ductus arteriosus closure in symptomatic preterm infants. Cochrane Database Of Systematic Reviews 2008, 2010: cd006071. PMID: 18254092, PMCID: PMC8912238, DOI: 10.1002/14651858.cd006071.pub2.Peer-Reviewed Original ResearchConceptsSymptomatic patent ductus arteriosusPatent ductus arteriosusTreatment of PDAContinuous indomethacin infusionRetinopathy of prematurityPDA closurePreterm infantsBolus administrationBolus injectionBlood flowBronchopulmonary dysplasiaIndomethacin infusionIntraventricular hemorrhagePremature infantsContinuous infusionMesenteric circulationRelative riskRisk differencePatent ductus arteriosus closureCerebral blood flow velocityAdverse effectsCochrane Neonatal reviewsContinuous infusion groupIntermittent bolus dosesSymptomatic preterm infants
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose