1999
Magnetic resonance imaging and neurological recovery in acute spinal cord injury: observations from the National Acute Spinal Cord Injury Study 3
Shepard M, Bracken M. Magnetic resonance imaging and neurological recovery in acute spinal cord injury: observations from the National Acute Spinal Cord Injury Study 3. Spinal Cord 1999, 37: 833-837. PMID: 10602525, DOI: 10.1038/sj.sc.3100927.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingAcute spinal cord injurySpinal cord injuryCord injuryMotor functionResonance imagingSpinal cord injury centerBlind clinical trialInitial neurological examinationInitial clinical examinationLight touch sensationComplete cord injurySpinal cord surgeryMultiple logistic regressionNational InstitutePresence of edemaComplete injuryNeurological recoveryRandomized patientsStudy drugCord edemaNeurological statusCord surgeryNeurological examinationNeurological assessment
1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-Care
1997
Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study.
Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, Fehlings M, Herr DL, Hitchon PW, Marshall LF, Nockels RP, Pascale V, Perot PL, Piepmeier J, Sonntag VK, Wagner F, Wilberger JE, Winn HR, Young W. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997, 277: 1597-604. PMID: 9168289, DOI: 10.1001/jama.277.20.1597.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNational Acute Spinal Cord Injury StudyFunctional Independence MeasureHours of injuryCord injuryTirilazad groupRegimen groupMethylprednisolone infusionAcute Spinal Cord Injury StudySpinal Cord Injury StudySpinal cord injury centerEfficacy of methylprednisoloneImproved motor recoveryMotor recovery rateAdministration of methylprednisoloneMotor function changesSteroid therapyMethylprednisolone groupSevere sepsisTirilazad mesylateMotor recoveryControlled TrialsInitial presentationIntravenous bolus
1994
The effectiveness of surgery on the treatment of acute spinal cord injury and its relation to pharmacological treatment.
Duh M, Shepard M, Wilberger J, Bracken M. The effectiveness of surgery on the treatment of acute spinal cord injury and its relation to pharmacological treatment. Neurosurgery 1994, 35: 240-8; discussion 248-9. PMID: 7969831, DOI: 10.1227/00006123-199408000-00009.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryPharmacological treatmentSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudySevere spinal cord injuryTraumatic spinal cord injuryValue of surgeryRole of surgeryEffectiveness of surgerySpinal cord surgeryNASCIS IINeurological improvementEarly surgeryIncomplete injuriesNeurological recoveryNeurological scoreLate surgeryCord surgeryRandomized studySurgical treatmentMotor scores
1992
Respiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasing hormone and glucocorticoid
Ballard R, Ballard P, Bracken M, Moya F, Gross I, Creasy K, Padbury J, Polk D. Respiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasing hormone and glucocorticoid. The Lancet 1992, 339: 510-515. PMID: 1346877, DOI: 10.1016/0140-6736(92)90337-3.Peer-Reviewed Original ResearchMeSH KeywordsBetamethasoneChronic DiseaseDouble-Blind MethodDrug Therapy, CombinationFemaleHumansInfant, Low Birth WeightInfant, NewbornInfant, Premature, DiseasesLung DiseasesMalePregnancyPrenatal CareRespiration, ArtificialRespiratory Distress Syndrome, NewbornRisk FactorsThyrotropin-Releasing HormoneConceptsChronic lung diseaseThyrotropin-releasing hormoneRespiratory distress syndromePrenatal thyrotropin-releasing hormoneDistress syndromePostconceptional ageBirthweight infantsLung diseaseSevere respiratory distress syndromeSteroid-alone groupNeonatal respiratory morbidityComplications of prematurityUnadjusted relative riskPrenatal glucocorticoid treatmentWeeks postconceptional ageTRH therapyPreterm deliveryRespiratory morbidityWeeks' gestationGlucocorticoid treatmentNeonatal periodAdverse outcomesTotal incidencePrenatal treatmentRelative riskMethylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function
1991
Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial.
Bracken M. Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial. Journal Of Neurotrauma 1991, 8 Suppl 1: s47-50; discussion s51-2. PMID: 1920461.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseDouble-Blind MethodHumansMethylprednisoloneNaloxoneNeurologic ExaminationSpinal Cord InjuriesTime FactorsConceptsAcute spinal cord injurySpinal cord injuryCord injuryAdministration of methylprednisoloneApparent contraindicationsNeurological improvementClinical trialsPermanent paralysisMethylprednisoloneLow dosesInjuryAdministrationDosesTrialsTreatmentMulticenterPlaceboContraindicationsNaloxoneParalysisDose
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose
1985
Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Hellenbrand K, Collins W, Leo L, Freeman D, Wagner F, Flamm E, Eisenberg H, Goodman J, Perot P, Green B, Grossman R, Meagher J, Young W, Fischer B, Clifton G, Hunt W, Rifkinson N. Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1985, 63: 704-13. PMID: 3903070, DOI: 10.3171/jns.1985.63.5.0704.Peer-Reviewed Original ResearchConceptsTotal steroid doseNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyHigh-dose methylprednisoloneSteroid treatment protocolFunction 1 yearCase fatality rateSpinal cord injuryPinprick responseSteroid doseNeurological recoveryCord injuryStandard dosePatient genderClinical trialsMotor functionTreatment protocolStudy groupInjury studiesTreatment groupsFatality rateInjuryMethylprednisoloneTreatment effects
1984
Efficacy of Methylprednisolone in Acute Spinal Cord Injury
Bracken M, Collins W, Freeman D, Shepard M, Wagner F, Silten R, Hellenbrand K, Ransohoff J, Hunt W, Perot P, Grossman R, Green B, Eisenberg H, Rifkinson N, Goodman J, Meagher J, Fischer B, Clifton G, Flamm E, Rawe S. Efficacy of Methylprednisolone in Acute Spinal Cord Injury. JAMA 1984, 251: 45-52. PMID: 6361287, DOI: 10.1001/jama.1984.03340250025015.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryEarly case fatalityEfficacy of methylprednisoloneHigh-dose regimenLight touch sensationHigh-dose protocolGroups six weeksNeurological recoveryCase fatalityWound infectionStandard doseMotor functionInitial lesionHigh doseOperative siteSix weeksInjuryMethylprednisoloneTreatment effectsTouch sensationDoseEfficacyMulticenter