2019
MNGI-12. PLEIOTROPIC MLLT10 VARIATION CONFERS RISK OF MENINGIOMA, BREAST, AND OVARIAN CANCERS
Walsh K, Zhang C, Calvocoressi L, Hansen H, Berchuck A, Schildkraut J, Bondy M, Wiemels J, Claus E. MNGI-12. PLEIOTROPIC MLLT10 VARIATION CONFERS RISK OF MENINGIOMA, BREAST, AND OVARIAN CANCERS. Neuro-Oncology 2019, 21: vi142-vi142. PMCID: PMC6847155, DOI: 10.1093/neuonc/noz175.594.Peer-Reviewed Original ResearchBody mass indexER- breast cancerRisk of meningiomaOvarian cancerBreast cancerMeningioma riskCancer riskElevated body mass indexHigher body fat percentageRisk allelesExogenous hormone useEstrogen receptor statusFemale breast cancerBreast cancer riskOvarian cancer riskBody fat percentageEndogenous hormonal factorsRecent genome-wide association studiesReceptor statusWaist circumferenceHormone useMass indexEpidemiologic studiesEstrogenic mechanismsHigh riskMendelian randomization provides support for obesity as a risk factor for meningioma
Takahashi H, Cornish AJ, Sud A, Law PJ, Disney-Hogg L, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Schildkraut JM, Simon M, Bondy M, Wrensch M, Wiemels JL, Claus EB, Turnbull C, Houlston RS. Mendelian randomization provides support for obesity as a risk factor for meningioma. Scientific Reports 2019, 9: 309. PMID: 30670737, PMCID: PMC6343031, DOI: 10.1038/s41598-018-36186-6.Peer-Reviewed Original ResearchConceptsRisk of meningiomaMeningioma riskObesity-related traitsLipoprotein cholesterolBlood pressureRisk factorsOdds ratioLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolMendelian randomizationCause of meningiomaGenetic instrumentsDiastolic blood pressureEpidemiological observational studiesSystolic blood pressureBody mass indexBody fat percentageWaist circumferenceTotal cholesterolMass indexObservational studyMeningioma patientsMeningiomasBasal metabolic rateObesity
2016
MNGO-11. REPORT FROM THE MENINGIOMA CONSORTIUM: CONFIRMATION OF A MENINGIOMA RISK LOCUS AT 10p12
Claus E, Calvocoressi L, Schildkraut J, Walsh K, Hansen H, Smirnov I, McCoy L, Lu L, Ma X, Bondy M, Wrensch M, Wiemels J. MNGO-11. REPORT FROM THE MENINGIOMA CONSORTIUM: CONFIRMATION OF A MENINGIOMA RISK LOCUS AT 10p12. Neuro-Oncology 2016, 18: vi103-vi103. DOI: 10.1093/neuonc/now212.432.Peer-Reviewed Original ResearchOdds ratioMeningioma riskMeningioma casesPrimary brain tumorsPopulation-based controlsCase/control studyNon-Hispanic CaucasiansAllele odds ratioGenome-wide association studiesKaiser Permanente Research ProgramSpinal cordSuch lesionsBrain tumorsControl studyConfidence intervalsFirst genome-wide association studyMeningiomasTumorsRisk lociUnited StatesSusceptibility lociRisk
2014
Endogenous and exogenous hormone exposure and the risk of meningioma in men.
Schildkraut JM, Calvocoressi L, Wang F, Wrensch M, Bondy ML, Wiemels JL, Claus EB. Endogenous and exogenous hormone exposure and the risk of meningioma in men. Journal Of Neurosurgery 2014, 120: 820-6. PMID: 24484233, PMCID: PMC4386752, DOI: 10.3171/2013.12.jns131170.Peer-Reviewed Original ResearchConceptsBody mass indexMeningioma riskOdds ratioHigher body mass indexExogenous hormone exposureMultivariate logistic regressionRelated risk factorsConfidence intervalsRisk of meningiomaPrevalence of exposureConsiderable morbidityMale patientsMass indexRisk factorsEndogenous estrogensReduced riskHormonal factorsHormone exposureIntracranial meningiomasExogenous exposureMeningiomasLogistic regressionUse of soyMenRisk
2012
Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females.
Claus EB, Calvocoressi L, Bondy ML, Wrensch M, Wiemels JL, Schildkraut JM. Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females. Journal Of Neurosurgery 2012, 118: 649-56. PMID: 23101448, PMCID: PMC3756881, DOI: 10.3171/2012.9.jns12811.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedBody Mass IndexBreast FeedingConnecticutContraceptives, OralEstrogen Replacement TherapyFemaleHumansMassachusettsMenarcheMeningeal NeoplasmsMeningiomaMenopauseMiddle AgedMultivariate AnalysisNorth CarolinaOdds RatioParityRegistriesReproductive HistoryRisk AssessmentRisk FactorsSan FranciscoSmokingTexasConceptsBody mass indexMeningioma riskMass indexIntracranial meningiomasExogenous hormone useHormone replacement therapyRisk of meningiomaYears of ageCurrent useResidents of ConnecticutHormone medicationWomen 29Postmenopausal womenPremenopausal womenCurrent smokingFertility medicationsOral contraceptivesHormone useMenstrual factorsSignificant positive associationCigarette smokingReplacement therapyRisk factorsReproductive factorsSignificant elevationCigarette Smoking and Risk of Meningioma: The Effect of Gender
Claus EB, Walsh KM, Calvocoressi L, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL. Cigarette Smoking and Risk of Meningioma: The Effect of Gender. Cancer Epidemiology Biomarkers & Prevention 2012, 21: 943-950. PMID: 22473761, PMCID: PMC3613227, DOI: 10.1158/1055-9965.epi-11-1059.Peer-Reviewed Original ResearchConceptsCigarette smokingIntracranial meningiomasCase-control studyRisk of meningiomaDuration of useEffect of genderPast smokersMenopausal statusHormonal etiologyFemale casesMale casesMeningioma riskReduced riskElevated riskMeningioma casesSmokingCase statusGreater riskSimilar findingsMeningiomasRiskAdditional investigationNumber of studiesInconsistent findingsWomen
2011
Family and personal medical history and risk of meningioma.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. Journal Of Neurosurgery 2011, 115: 1072-7. PMID: 21780859, PMCID: PMC3241000, DOI: 10.3171/2011.6.jns11129.Peer-Reviewed Original ResearchConceptsFirst-degree family historyPersonal medical historyMedical historyFamily historyMeningioma riskEpidemiology of meningiomaPrimary brain tumorsCase-control studyRisk of meningiomaUterine fibroid tumorsImmune conditionsThyroid cancerYoungest caseBreast cancerRole of hormonesBrain tumorsFibroid tumorsImmune systemControl individualsPatientsMeningiomasInfluence of geneticsStrong associationFurther studiesTumors
2007
Exogenous hormone use and meningioma risk
Claus EB, Black PM, Bondy ML, Calvocoressi L, Schildkraut JM, Wiemels JL, Wrensch M. Exogenous hormone use and meningioma risk. Cancer 2007, 110: 471-476. PMID: 17580362, DOI: 10.1002/cncr.22783.Peer-Reviewed Original ResearchConceptsCase-control studyExogenous hormone useHormone replacement therapyMeningioma riskOral contraceptivesHormone useReplacement therapyHospital-based case-control studyPopulation-based case-control studyRandomized clinical trial dataTumor receptor subtypeRetrospective cohort studyCommon clinical questionsLarge national cohortRisk of meningiomaClinical trial dataEnglish-language literatureCohort studyNational cohortReceptor subtypesClinical questionsIntracranial meningiomasTrial dataFurther evaluationExogenous hormones