2018
Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats
Gao HT, Xu R, Cao WX, Di QN, Li RX, Lu L, Xu Q, Yu SQ. Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats. Toxicology And Applied Pharmacology 2018, 341: 87-97. PMID: 29366639, DOI: 10.1016/j.taap.2018.01.013.Peer-Reviewed Original ResearchConceptsRat reproductive systemFood emulsifier glycerin monostearateReproductive systemMale rat reproductive systemSteroidogenic proteinsMale reproductive toxicityMale reproductive systemTime-dependent mannerSerum testosteroneAndrogen metabolismMale ratsReproductive toxicityMorphological damageUbiquitous phthalate estersMetabonomic analysisDaily dietSimultaneous exposureToxic effectsRatsGlycerin monostearateMixPToxicityHormone biosynthesisExposureGavage
2016
Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats
Gao HT, Xu R, Cao WX, Zhou X, Yan YH, Lu L, Xu Q, Shen Y. Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats. PLOS ONE 2016, 11: e0161253. PMID: 27575856, PMCID: PMC5004918, DOI: 10.1371/journal.pone.0161253.Peer-Reviewed Original ResearchConceptsInternal exposure levelsReproductive toxicityExposure levelsMale ratsTestosterone levelsFood emulsifier glycerin monostearatePAE exposureHistopathology of testesMale reproductive toxicityDEHP groupRat urineUbiquitous phthalate estersRatsPhthalate monoestersHistopathologyInjuryToxicityTestisGlycerin monostearatePrimary metabolitesExposureUPLC-MSFood additivesGavageLevels