2022
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
Zhou Y, Gu B, Brichant G, Singh JP, Yang H, Chang H, Zhao Y, Cheng C, Liu ZW, Alderman MH, Lu L, Yang X, Gao XB, Taylor HS. The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract. BMC Biology 2022, 20: 93. PMID: 35491423, PMCID: PMC9059368, DOI: 10.1186/s12915-022-01293-4.Peer-Reviewed Original ResearchConceptsEstrogen receptorMaintenance of pregnancyFetal mouse brainReproductive systemE3 micePregnancy outcomesEstrogen actionEstrogen potencyPregnant miceEstrogen exposureEstrogen signalingFetal developmentMouse brainSteroid hormonesUnexpected functional rolesPregnancyReproductive tractHormone estriolBrainReceptorsExpression levelsFetusesExploratory behaviorMiceNovel mechanism
2020
Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium
Jordan SJ, Na R, Weiderpass E, Adami H, Anderson KE, van den Brandt P, Brinton LA, Chen C, Cook LS, Doherty JA, Du M, Friedenreich CM, Gierach GL, Goodman MT, Krogh V, Levi F, Lu L, Miller AB, McCann SE, Moysich KB, Negri E, Olson SH, Petruzella S, Palmer JR, Parazzini F, Pike MC, Prizment AE, Rebbeck TR, Reynolds P, Ricceri F, Risch HA, Rohan TE, Sacerdote C, Schouten LJ, Serraino D, Setiawan VW, Shu X, Sponholtz TR, Spurdle AB, Stolzenberg‐Solomon R, Trabert B, Wentzensen N, Wilkens LR, Wise LA, Yu H, La Vecchia C, De Vivo I, Xu W, Zeleniuch‐Jacquotte A, Webb PM. Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium. International Journal Of Cancer 2020, 148: 2068-2078. PMID: 33105052, PMCID: PMC7969437, DOI: 10.1002/ijc.33360.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskFull-term pregnancyLast full-term pregnancyEndometrial Cancer ConsortiumCancer riskEndometrial cancerIndividual participant dataIncomplete pregnanciesPooled analysisAdditional pregnanciesOdds ratioCancer ConsortiumFirst full-term pregnancyParticipant dataPregnancy-related factorsPooled odds ratioCase-control studyHigh progesterone levelsRisk reductionLast pregnancyPregnancy outcomesSingleton pregnanciesControl womenLast trimesterProgesterone levels