2020
tRFtarget: a database for transfer RNA-derived fragment targets
Li N, Shan N, Lu L, Wang Z. tRFtarget: a database for transfer RNA-derived fragment targets. Nucleic Acids Research 2020, 49: d254-d260. PMID: 33035346, PMCID: PMC7779015, DOI: 10.1093/nar/gkaa831.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase PairingBase SequenceCaenorhabditis elegansDatabases, Nucleic AcidDrosophila melanogasterGene OntologyHumansMiceMolecular Sequence AnnotationNucleic Acid ConformationNucleic Acid HybridizationRhodobacter sphaeroidesRNA, MessengerRNA, Small UntranslatedRNA, TransferSchizosaccharomycesThermodynamicsXenopusZebrafishConceptsTarget genesTransfer RNASmall non-coding RNAsGene Ontology annotationsNon-coding RNAsFunctional pathway analysisAccessible web-based databaseMolecular functionsOntology annotationsBiological functionsPathway analysisMolecular mechanismsPhysiological processesTarget predictionHuman diseasesGenesMRNA transcriptsRNAWeb-based databaseConvenient linkTRFImportant roleRNAhybridTargetIntaRNA
2016
Metformin alters DNA methylation genome-wide via the H19/SAHH axis
Zhong T, Men Y, Lu L, Geng T, Zhou J, Mitsuhashi A, Shozu M, Maihle NJ, Carmichael GG, Taylor HS, Huang Y. Metformin alters DNA methylation genome-wide via the H19/SAHH axis. Oncogene 2016, 36: 2345-2354. PMID: 27775072, PMCID: PMC5415944, DOI: 10.1038/onc.2016.391.Peer-Reviewed Original ResearchConceptsS-adenosylhomocysteine hydrolaseDNA methylation genomeGenome-wide alterationsNovel mechanismSubset of genesDNA methyltransferase 3BMethylation genomeDNA methylationEpigenetic dysregulationPathway genesMolecular basisAMPK activationLet-7Methyltransferase 3BMolecular mechanismsEndometrial cancer tissue samplesH19 knockdownGene methylationCell proliferationCancer tissue samplesCancer cellsNormal cellsConcomitant inhibitionGenesMethylationH19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction
Zuckerwise L, Li J, Lu L, Men Y, Geng T, Buhimschi CS, Buhimschi IA, Bukowski R, Guller S, Paidas M, Huang Y. H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction. Oncotarget 2016, 7: 38398-38407. PMID: 27223264, PMCID: PMC5122399, DOI: 10.18632/oncotarget.9534.Peer-Reviewed Original ResearchConceptsFetal growth restrictionGrowth restrictionExtravillous trophoblastsDownregulation of H19Type III TGF-β receptorCell migrationEVT cell migrationNon-canonical TGFTGF-β receptorFGR placentasNeurodevelopmental impairmentPerinatal mortalityRisk factorsTherapeutic modalitiesEVT cellsH19 knockdownOnset disordersPlacentaInvasionMolecular mechanismsH19Let-7Novel regulatory targetMorbidityRegulatory pathways