2024
Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression
Kienzl P, Deloria A, Hunjadi M, Hadolt J, Haering M, Bothien A, Mejri D, Korkut-Demirbaş M, Sampl S, Weber G, Pirker C, Laengle S, Braunschmid T, Dragona E, Marian B, Gagos S, Lu L, Henson J, Lau L, Reddel R, Mikulits W, Stättner S, Holzmann K. Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression. Cellular Oncology 2024, 1-9. PMID: 39222177, DOI: 10.1007/s13402-024-00986-y.Peer-Reviewed Original ResearchSevere combined immunodeficiency diseaseTelomerase reverse transcriptaseProliferating cell nuclear antigenEpithelial-mesenchymal transitionColorectal cancerTelomerase RNA componentTumor tissuesTelomerase activityTelomeric repeat-containing RNAProliferating cell nuclear antigen expressionAssociated with favorable prognosisOverall survival rateCombined immunodeficiency diseaseTelomere lengthEpithelial splicing regulatory protein 1TERRA expressionColorectal cancer tumor tissuesCell nuclear antigenNon-canonical functions of telomerase reverse transcriptaseCRC tumor growthExpression levelsFavorable prognosisNon-tumor tissuesImmunodeficiency diseaseAdjacent non-tumor tissues
2022
Tiliroside suppresses triple-negative breast cancer as a multifunctional CAXII inhibitor
Han R, Yang H, Ling C, Lu L. Tiliroside suppresses triple-negative breast cancer as a multifunctional CAXII inhibitor. Cancer Cell International 2022, 22: 368. PMID: 36424626, PMCID: PMC9685933, DOI: 10.1186/s12935-022-02786-6.Peer-Reviewed Original ResearchTriple-negative breast cancerBreast cancerTNBC cellsBreast cancer treatmentNegative breast cancerCaspase-3 activity analysisExpression levelsSpheroid formation assayFurther RT-PCRTNBC patientsTumor burdenEarly recurrencePoor prognosisAggressive subtypeChemotherapy responseAlternative therapiesPreclinical studiesTNBC progressionMouse modelTherapeutic implicationsPreclinical experimentsSurvival rateTherapeutic useClinic practiceLevel assaysThe steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
Zhou Y, Gu B, Brichant G, Singh JP, Yang H, Chang H, Zhao Y, Cheng C, Liu ZW, Alderman MH, Lu L, Yang X, Gao XB, Taylor HS. The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract. BMC Biology 2022, 20: 93. PMID: 35491423, PMCID: PMC9059368, DOI: 10.1186/s12915-022-01293-4.Peer-Reviewed Original ResearchConceptsEstrogen receptorMaintenance of pregnancyFetal mouse brainReproductive systemE3 micePregnancy outcomesEstrogen actionEstrogen potencyPregnant miceEstrogen exposureEstrogen signalingFetal developmentMouse brainSteroid hormonesUnexpected functional rolesPregnancyReproductive tractHormone estriolBrainReceptorsExpression levelsFetusesExploratory behaviorMiceNovel mechanism
2020
MicroRNA‑34a expression affects breast cancer invasion in vitro and patient survival via downregulation of E2F1 and E2F3 expression.
Han R, Zhao J, Lu L. MicroRNA‑34a expression affects breast cancer invasion in vitro and patient survival via downregulation of E2F1 and E2F3 expression. Oncology Reports 2020, 43: 2062-2072. PMID: 32186770, DOI: 10.3892/or.2020.7549.Peer-Reviewed Original ResearchConceptsBreast cancerNormal breast tissueMDA-MB-231 cellsPatient survivalT-47DKaplan-Meier survival curvesBreast tissueCancer-associated mortalityLonger survival timeCommon cancer typesExpression levelsReverse transcription-quantitative PCRPotential therapeutic toolBreast cancer invasionMicroRNA-34a expressionTranscription-quantitative PCRTumor cell proliferationOverall survivalUnderlying molecular mechanismsCaspase-3 activityDownregulation of E2F1Clinical managementExpression of E2F1Survival timeClinical relevance
2014
Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line
Hu X, Zhang J, Jiang Y, Lei Y, Lu L, Zhou J, Huang H, Fang D, Tao G. Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line. Toxicology In Vitro 2014, 28: 1377-1385. PMID: 25063376, DOI: 10.1016/j.tiv.2014.07.004.Peer-Reviewed Original ResearchConceptsPregnane X receptorThyroid receptorX receptorRegulation of CYP3A4Microsomal phase ITetra-bromodiphenyl etherHuman pregnane X receptorDual-luciferase reporterHepG2 cell modelBDE-47Human hepatoma cell lineDetailed underlying mechanismsMetabolic enzymesHepatoma cell lineThyroid hormonesBDE-47 treatmentToxicological evidencePhase IHealth effectsThyroid disruptionReceptorsExpression levelsHPXRUnderlying mechanismUGT1A3