2023
Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada
Weichenthal S, Lavigne E, You H, Pollitt K, Shin T, Kulka R, Stieb D, Hatzopoulou M, Evans G, Burnett R. Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada. Epidemiology 2023, 34: 897-905. PMID: 37732880, DOI: 10.1097/ede.0000000000001651.Peer-Reviewed Original ResearchMeSH KeywordsAgedCanadaCross-Over StudiesDustHospitalizationHumansMyocardial IschemiaOxidative StressTemperatureConceptsIschaemic heart disease eventsHeart disease eventsAcute cardiovascular eventsCardiovascular eventsDisease eventsOdds ratioPotential time-varying confoundersAcute cardiovascular effectsFine particulate air pollutionCase-crossover studyOutdoor fine particulate air pollutionHealth impactsCardiovascular health impactsParticulate air pollutionCardiovascular effectsHighest tertileTime-varying confoundersOlder subjectsHospitalizationObserved associationsOxidative stressOxidative potentialPM2.5 oxidative potentialMonthsAssociation
2022
Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential.
Korsiak J, Lavigne E, You H, Pollitt K, Kulka R, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1370-1378. PMID: 35802828, DOI: 10.1164/rccm.202205-0896oc.Peer-Reviewed Original ResearchConceptsRespiratory hospitalizationsConditional logistic regression modelsPediatric respiratory hospitalizationsFine particulate air pollutionCase-crossover studyLogistic regression modelsParticulate air pollutionOxidant gasesRespiratory healthEffect modificationOdds ratioHospitalizationParticle oxidative potentialStrong associationConfidence intervalsOxidative potentialMedianPositive associationChildrenAssociationMedian valueRegression modelsFine particulate matterOutdoor fine particlesAir pollutionLong-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential
Toyib O, Lavigne E, Traub A, Umbrio D, You H, Ripley S, Pollitt K, Shin T, Kulka R, Jessiman B, Tjepkema M, Martin R, Stieb DM, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Long-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential. Epidemiology 2022, 33: 767-776. PMID: 36165987, PMCID: PMC9531968, DOI: 10.1097/ede.0000000000001538.Peer-Reviewed Original ResearchConceptsLong-term exposureOxidative stressFine particulate air pollutionProportional hazards modelAir pollution health effectsHealth impactsObserved health impactsParticulate air pollutionCohort studyMortality outcomesOxidant gasesEffect modificationInterquartile increaseHazards modelAdverse health impactsNonaccidental mortalityGSH levelsHealth effectsMortalityLand use regression modelsOxidative potentialMedianRegression modelsExposurePM 2.5
2021
Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada
Ripley S, Minet L, Zalzal J, Godri Pollitt K, Gao D, Lakey PSJ, Shiraiwa M, Maher BA, Hatzopoulou M, Weichenthal S. Predicting Spatial Variations in Multiple Measures of PM2.5 Oxidative Potential and Magnetite Nanoparticles in Toronto and Montreal, Canada. Environmental Science And Technology 2021, 56: 7256-7265. PMID: 34965092, DOI: 10.1021/acs.est.1c05364.Peer-Reviewed Original ResearchAssociation of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults
Weichenthal S, Lavigne E, Traub A, Umbrio D, You H, Pollitt K, Shin T, Kulka R, Stieb DM, Korsiak J, Jessiman B, Brook JR, Hatzopoulou M, Evans G, Burnett RT. Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults. Environmental Health Perspectives 2021, 129: 107005. PMID: 34644144, PMCID: PMC8513754, DOI: 10.1289/ehp9449.Peer-Reviewed Original ResearchConceptsAcute cardiovascular eventsCardiovascular eventsCase-crossover studyOdds ratioConditional logistic regression modelsFine particulate air pollutionLogistic regression modelsParticulate air pollutionStrength of associationCanadian adultsPopulation health risksObserved associationsRecent evidenceWeak associationOxidative potentialHealth impactsMenAssociationHealth risksMedian valueRegression modelsInfluence associationsAssociated health impactsSimilar patternOutdoor PM2.5Predicting Spatial Variations in Multiple Measures of Oxidative Burden for Outdoor Fine Particulate Air Pollution across Canada
Xu JW, Martin RV, Evans GJ, Umbrio D, Traub A, Meng J, van Donkelaar A, You H, Kulka R, Burnett RT, Pollitt K, Weichenthal S. Predicting Spatial Variations in Multiple Measures of Oxidative Burden for Outdoor Fine Particulate Air Pollution across Canada. Environmental Science And Technology 2021, 55: 9750-9760. PMID: 34241996, DOI: 10.1021/acs.est.1c01210.Peer-Reviewed Original ResearchUse of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum
Jin L, Godri Pollitt KJ, Liew Z, Rosen Vollmar AK, Vasiliou V, Johnson CH, Zhang Y. Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum. Current Environmental Health Reports 2021, 8: 7-22. PMID: 33420964, DOI: 10.1007/s40572-020-00298-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir PollutantsAir PollutionChildEnvironmental ExposureFemaleHumansMetabolomicsOxidative StressParticulate MatterPregnancyConceptsAir pollutant exposureAdverse health effectsSpecific adverse health effectsOxidative stressHealth effectsPerturbation of metabolitesAir pollution exposureUntargeted metabolomicsPollutant exposureSteroid metabolic pathwaysPregnant womenInflammatory responseDisease continuumReviewThe purposeHealth outcomesLarger sample sizeMetabolic pathwaysDisease statusPollution exposureIdentified metabolitesMetabolic perturbationsMetabolic changesSummaryOur reviewAir pollution componentsMetabolomic analysis
2020
Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management
Gao D, Ripley S, Weichenthal S, Godri Pollitt KJ. Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management. Free Radical Biology And Medicine 2020, 151: 7-25. PMID: 32430137, DOI: 10.1016/j.freeradbiomed.2020.04.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsHumansOxidation-ReductionOxidative StressParticulate MatterRisk ManagementConceptsOxidative potentialRedox-active metalsRedox propertiesPM chemical constituentsOrganic speciesPM oxidative potentialTarget moleculesFine PM massOP assaysChemical constituentsChemical determinantsParticulate matter toxicityOP responseMass concentrationAssociated health effectsPM speciesAir pollution exposure assessmentMetalsEpidemiological studiesHealth outcomesEpidemiologic literaturePollution exposure assessmentHealth effectsRedoxExposure assessment
2018
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study
Liu L, Urch B, Szyszkowicz M, Evans G, Speck M, Van Huang A, Leingartner K, Shutt RH, Pelletier G, Gold DR, Brook JR, Godri Pollitt K, Silverman FS. Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environment International 2018, 121: 1331-1340. PMID: 30420132, PMCID: PMC6396878, DOI: 10.1016/j.envint.2018.10.055.Peer-Reviewed Original ResearchConceptsUbiquitin C-terminal hydrolase L1Vascular endothelium growth factorBiomarker levelsPost exposureSystemic inflammationOxidative stressNeural biomarkersS100 calcium-binding protein BCalcium-binding protein BNeural functionHealthy non-smoking volunteersConcentrated ambient PMAssessment of biomarkersNon-smoking volunteersStress marker cortisolAmbient PMUrinary malondialdehydeUrinary biomarkersUrinary cortisolInterleukin-6Mixed regression modelsVanillylmandelic acidInflammationMean concentrationGrowth factorFine Particulate Air Pollution and Adverse Birth Outcomes: Effect Modification by Regional Nonvolatile Oxidative Potential
Lavigne É, Burnett RT, Stieb DM, Evans GJ, Godri Pollitt KJ, Chen H, van Rijswijk D, Weichenthal S. Fine Particulate Air Pollution and Adverse Birth Outcomes: Effect Modification by Regional Nonvolatile Oxidative Potential. Environmental Health Perspectives 2018, 126: 077012. PMID: 30073952, PMCID: PMC6108848, DOI: 10.1289/ehp2535.Peer-Reviewed Original ResearchConceptsTerm low birth weightLow birth weightAdverse birth outcomesPreterm birthBirth outcomesHighest quartileBirth weightEffect modificationFirst trimester PMRetrospective cohort studyTerm birth weightFine particulate air pollutionPossible effect modificationDays of deliveryFine particulate matter air pollutionParticulate matter air pollutionMatter air pollutionEffects of PMEstimate of effectParticulate air pollutionPreterm deliveryCohort studySingleton birthsPrenatal exposureImpact of PM
2016
Fine Particulate Matter and Emergency Room Visits for Respiratory Illness. Effect Modification by Oxidative Potential
Weichenthal SA, Lavigne E, Evans GJ, Pollitt K, Burnett RT. Fine Particulate Matter and Emergency Room Visits for Respiratory Illness. Effect Modification by Oxidative Potential. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 577-86. PMID: 26963193, DOI: 10.1164/rccm.201512-2434oc.Peer-Reviewed Original ResearchConceptsEmergency room visitsAcute respiratory morbidityRespiratory illnessRoom visitsImpact of PM2.5Respiratory morbidityChronic obstructive pulmonary diseaseAcute respiratory illnessObstructive pulmonary diseaseFine particulate air pollutionCases of asthmaConditional logistic regressionCase-crossover studyParticulate air pollutionRespiratory outcomesPulmonary diseaseEmergency roomEffect modificationRespiratory tractDaily air pollution dataInterquartile changeTime-varying covariatesOxidative burdenIllnessLogistic regressionMurine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions
Maikawa CL, Zimmerman N, Rais K, Shah M, Hawley B, Pant P, Jeong CH, Delgado-Saborit JM, Volckens J, Evans G, Wallace JS, Pollitt K. Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions. The Science Of The Total Environment 2016, 568: 1102-1109. PMID: 27369091, DOI: 10.1016/j.scitotenv.2016.06.173.Peer-Reviewed Original ResearchConceptsLung slicesPulmonary responseBALB/c miceMurine precision-cut lung slicesOxidative stressPrecision-cut lung slicesOxidative stress markersOne-hour exposurePulmonary effectsC miceGDI engine exhaustAcute responseCYP1B1 expressionStress markersVivo modelPolycyclic aromatic hydrocarbon metabolismUpregulation of genesElectrostatic aerosolParticulate fractionAromatic hydrocarbon metabolismExposureUpregulated genesMRNA productionMetabolismAir-liquid interface
2015
Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC)
Weichenthal S, Crouse DL, Pinault L, Godri-Pollitt K, Lavigne E, Evans G, van Donkelaar A, Martin RV, Burnett RT. Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC). Environmental Research 2015, 146: 92-99. PMID: 26745732, DOI: 10.1016/j.envres.2015.12.013.Peer-Reviewed Original ResearchConceptsCause-specific mortalityFine particulate air pollutionOxidative burdenParticulate air pollutionHazard ratioLung cancer hazard ratiosLong-term mortality riskCox proportional hazards modelCanadian Census HealthCancer hazard ratioLung cancer mortalityRisk of mortalityProportional hazards modelRespiratory tract lining fluidCanadian Long Form CensusEnvironment CohortSynthetic respiratory tract lining fluidCancer mortalityLung cancerLining fluidMortality riskHazards modelIndividual-level covariatesInterquartile changeLong-form census
2013
PM2.5, oxidant defence and cardiorespiratory health: a review
Weichenthal SA, Godri Pollitt K, Villeneuve PJ. PM2.5, oxidant defence and cardiorespiratory health: a review. Environmental Health 2013, 12: 40. PMID: 23641908, PMCID: PMC3652795, DOI: 10.1186/1476-069x-12-40.Peer-Reviewed Original ResearchConceptsHealth effectsOxidant defenseAnti-oxidant related genesFurther evaluationOxidative stressCardiorespiratory health effectsLittle epidemiological evidenceAnti-oxidant supplementationPotential modifying roleAmbient air quality managementAcute health effectsImpact of polymorphismsHeart rate variabilityCardiorespiratory outcomesChronic outcomesRespiratory outcomesEpidemiological evidenceCardiorespiratory healthPM2.5 exposureHealth outcomesRate variabilityModifying roleExposure metricsOutcomesCommon outcome