2020
Assessment of Biomass Smoke Induced Pulmonary Response and the Protective Effect of Magnolol Using Physiologically Relevant Normal- and Chronic Bronchitis-Like Bronchial Mucosa Models
Upadhyay S, Rinaldi S, Thimraj T, Lin E, O'Brien F, Koelmel J, Ernstgård L, Johanson G, Mahesh P, Pollitt K, Palmberg L, Ganguly K. Assessment of Biomass Smoke Induced Pulmonary Response and the Protective Effect of Magnolol Using Physiologically Relevant Normal- and Chronic Bronchitis-Like Bronchial Mucosa Models. 2020, a2889-a2889. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2889.Peer-Reviewed Original Research
2018
Comparison of Airway Responses Induced in a Mouse Model by the Gas and Particulate Fractions of Gasoline Direct Injection Engine Exhaust
Maikawa CL, Zimmerman N, Ramos M, Shah M, Wallace JS, Pollitt KJG. Comparison of Airway Responses Induced in a Mouse Model by the Gas and Particulate Fractions of Gasoline Direct Injection Engine Exhaust. International Journal Of Environmental Research And Public Health 2018, 15: 429. PMID: 29494515, PMCID: PMC5876974, DOI: 10.3390/ijerph15030429.Peer-Reviewed Original ResearchConceptsAirway hyperresponsivenessAllergic asthma murine modelAsthma murine modelNon-allergic miceMethacholine responsivenessAirway responsesPulmonary responsePeripheral tissuesMurine modelMouse modelShort-term exposureAcute exposureGDI engine exhaustPolycyclic aromatic hydrocarbon metabolismUpregulation of genesHyperresponsivenessParticulate fractionHealth impactsAromatic hydrocarbon metabolismPrevalenceMiceExposureDiesel exhaustAnimalsResponse
2016
Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions
Maikawa CL, Zimmerman N, Rais K, Shah M, Hawley B, Pant P, Jeong CH, Delgado-Saborit JM, Volckens J, Evans G, Wallace JS, Pollitt K. Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions. The Science Of The Total Environment 2016, 568: 1102-1109. PMID: 27369091, DOI: 10.1016/j.scitotenv.2016.06.173.Peer-Reviewed Original ResearchConceptsLung slicesPulmonary responseBALB/c miceMurine precision-cut lung slicesOxidative stressPrecision-cut lung slicesOxidative stress markersOne-hour exposurePulmonary effectsC miceGDI engine exhaustAcute responseCYP1B1 expressionStress markersVivo modelPolycyclic aromatic hydrocarbon metabolismUpregulation of genesElectrostatic aerosolParticulate fractionAromatic hydrocarbon metabolismExposureUpregulated genesMRNA productionMetabolismAir-liquid interface