2019
Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives
Hung S, Mohan A, Reckhow DA, Godri Pollitt KJ. Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives. Chemosphere 2019, 234: 902-908. PMID: 31519098, DOI: 10.1016/j.chemosphere.2019.06.086.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesNormal human colon cellsHuman liver cancer cellsConcentration-dependent decreaseLiver cancer cellsIntracellular reactive oxygen speciesHuman colon cellsStudy designCell culture mediumCancer cellsColon cellsROS productionCulture mediumGreater cytotoxicityCell linesAcute cytotoxicityCell viabilityToxicological profileToxicological studiesCytotoxicityToxicityEnhanced toxicityOxygen speciesCell mediumPotential underestimation
2016
Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma
Maikawa CL, Weichenthal S, Wheeler AJ, Dobbin NA, Smargiassi A, Evans G, Liu L, Goldberg MS, Pollitt KJ. Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma. Environmental Health Perspectives 2016, 124: 1616-1622. PMID: 27152705, PMCID: PMC5047770, DOI: 10.1289/ehp175.Peer-Reviewed Original ResearchOxidative burdenAirway inflammationNitric oxideAsthmatic school-aged childrenExhaled Nitric OxideReactive oxygen speciesPM2.5 personal exposureFeNO levelsFeNO responseCorticosteroid useAsthmatic symptomsAsthmatic childrenSchool-aged childrenRespiratory tractOxygen speciesEpidemiological studiesFeNOFluid liningConsecutive daysPersonal exposurePersonal exposure samplesAsthmaBurdenAllergyChildren