2023
Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada
Weichenthal S, Lavigne E, You H, Pollitt K, Shin T, Kulka R, Stieb D, Hatzopoulou M, Evans G, Burnett R. Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada. Epidemiology 2023, 34: 897-905. PMID: 37732880, DOI: 10.1097/ede.0000000000001651.Peer-Reviewed Original ResearchConceptsIschaemic heart disease eventsHeart disease eventsAcute cardiovascular eventsCardiovascular eventsDisease eventsOdds ratioPotential time-varying confoundersAcute cardiovascular effectsFine particulate air pollutionCase-crossover studyOutdoor fine particulate air pollutionHealth impactsCardiovascular health impactsParticulate air pollutionCardiovascular effectsHighest tertileTime-varying confoundersOlder subjectsHospitalizationObserved associationsOxidative stressOxidative potentialPM2.5 oxidative potentialMonthsAssociationWithin-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort
Ripley S, Gao D, Pollitt K, Lakey P, Shiraiwa M, Hatzopoulou M, Weichenthal S. Within-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort. Environmental Epidemiology 2023, 7: e257. PMID: 37545813, PMCID: PMC10403014, DOI: 10.1097/ee9.0000000000000257.Peer-Reviewed Original ResearchCanadian Census HealthCardiovascular mortalityReactive oxygen species concentrationParticulate air pollutionEnvironment CohortMeasures of PMRetrospective cohort studyFine particulate air pollutionRelevant confounding factorsProportional hazards modelOutdoor fine particulate air pollutionPopulation health impactHealth impactsCardiovascular health impactsOutdoor air pollutionCardiovascular deathCohort studyOxidant gasesEffect modificationHazards modelConfounding factorsMortalityOxidative stressHealth effectsOxidative potential
2022
Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential.
Korsiak J, Lavigne E, You H, Pollitt K, Kulka R, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1370-1378. PMID: 35802828, DOI: 10.1164/rccm.202205-0896oc.Peer-Reviewed Original ResearchConceptsRespiratory hospitalizationsConditional logistic regression modelsPediatric respiratory hospitalizationsFine particulate air pollutionCase-crossover studyLogistic regression modelsParticulate air pollutionOxidant gasesRespiratory healthEffect modificationOdds ratioHospitalizationParticle oxidative potentialStrong associationConfidence intervalsOxidative potentialMedianPositive associationChildrenAssociationMedian valueRegression modelsFine particulate matterOutdoor fine particlesAir pollutionLong-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential
Toyib O, Lavigne E, Traub A, Umbrio D, You H, Ripley S, Pollitt K, Shin T, Kulka R, Jessiman B, Tjepkema M, Martin R, Stieb DM, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Long-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential. Epidemiology 2022, 33: 767-776. PMID: 36165987, PMCID: PMC9531968, DOI: 10.1097/ede.0000000000001538.Peer-Reviewed Original ResearchConceptsLong-term exposureOxidative stressFine particulate air pollutionProportional hazards modelAir pollution health effectsHealth impactsObserved health impactsParticulate air pollutionCohort studyMortality outcomesOxidant gasesEffect modificationInterquartile increaseHazards modelAdverse health impactsNonaccidental mortalityGSH levelsHealth effectsMortalityLand use regression modelsOxidative potentialMedianRegression modelsExposurePM 2.5
2021
Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults
Weichenthal S, Lavigne E, Traub A, Umbrio D, You H, Pollitt K, Shin T, Kulka R, Stieb DM, Korsiak J, Jessiman B, Brook JR, Hatzopoulou M, Evans G, Burnett RT. Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults. Environmental Health Perspectives 2021, 129: 107005. PMID: 34644144, PMCID: PMC8513754, DOI: 10.1289/ehp9449.Peer-Reviewed Original ResearchConceptsAcute cardiovascular eventsCardiovascular eventsCase-crossover studyOdds ratioConditional logistic regression modelsFine particulate air pollutionLogistic regression modelsParticulate air pollutionStrength of associationCanadian adultsPopulation health risksObserved associationsRecent evidenceWeak associationOxidative potentialHealth impactsMenAssociationHealth risksMedian valueRegression modelsInfluence associationsAssociated health impactsSimilar patternOutdoor PM2.5
2020
Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management
Gao D, Ripley S, Weichenthal S, Godri Pollitt KJ. Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management. Free Radical Biology And Medicine 2020, 151: 7-25. PMID: 32430137, DOI: 10.1016/j.freeradbiomed.2020.04.028.Peer-Reviewed Original ResearchConceptsOxidative potentialRedox-active metalsRedox propertiesPM chemical constituentsOrganic speciesPM oxidative potentialTarget moleculesFine PM massOP assaysChemical constituentsChemical determinantsParticulate matter toxicityOP responseMass concentrationAssociated health effectsPM speciesAir pollution exposure assessmentMetalsEpidemiological studiesHealth outcomesEpidemiologic literaturePollution exposure assessmentHealth effectsRedoxExposure assessmentCharacterization and comparison of PM2.5 oxidative potential assessed by two acellular assays
Gao D, Pollitt K, Mulholland J, Russell A, Weber R. Characterization and comparison of PM2.5 oxidative potential assessed by two acellular assays. Atmospheric Chemistry And Physics 2020, 20: 5197-5210. DOI: 10.5194/acp-20-5197-2020.Peer-Reviewed Original ResearchWater-soluble CuOP assaysMetal ionsOxidative potentialMetal-metal interactionsChemical componentsHumic-like substancesAscorbic acidSynthetic respiratory tract lining fluidDepletion of dithiothreitolMetal speciesOrganic compoundsPM2.5 oxidative potentialBrown carbonMajor chemical componentsOPGSHIonsRespiratory tract lining fluidAcellular assaysParticle composition dataElemental carbonCuCarbonOPAAOPDTT