Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models
Ganguly K, Nordström A, Thimraj TA, Rahman M, Ramström M, Sompa SI, Lin EZ, O’Brien F, Koelmel J, Ernstgård L, Johanson G, Pollitt KJG, Palmberg L, Upadhyay S. Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models. Scientific Reports 2020, 10: 20460. PMID: 33235237, PMCID: PMC7686373, DOI: 10.1038/s41598-020-77452-w.Peer-Reviewed Original ResearchConceptsElectronic cigarettesSafety profilingInjury/repairMucosa modelEpithelial barrier functionExpression of markersNicotine contentAnti-microbial defenseTissue injury/repairNicotine presenceHuman bronchialFlavoring agentBarrier functionLung modelOxidative stressEvidence-based policy recommendationsSignificant differencesRespiratory treeMulti-disciplinary approachLimited toxicity dataMultiple factorsAir-liquid interfaceSpecific roleToxicityCytotoxic compoundsClinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020
Anand M, Larsson K, Johanson G, Phuleria HC, Ravindra PV, Ernstgård L, Mabalirajan U, Krishna M, Palmberg L, Pollitt KJG, Upadhyay S, Ganguly K. Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020. Toxics 2020, 8: 68. PMID: 32899560, PMCID: PMC7560295, DOI: 10.3390/toxics8030068.Peer-Reviewed Original ResearchAdverse health effectsHealth effectsBiomass smoke exposureAdverse health outcomesPotential protective mechanismDeterminants of healthSmoke exposureEpidemiological field studiesHealth outcomesAdult cohortDietary exposureVivo modelProtective mechanismPersonalized exposure assessmentExposure assessmentStudy objectiveNew screening methodExposureMysuruMulti-disciplinary approachFuture studiesOutcomesSpecific aimScreening methodPlausible strategy