2021
Autonomic Imbalance and Risk of Dementia and Stroke
Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke. Stroke 2021, 52: 2068-2076. PMID: 33874747, PMCID: PMC8154675, DOI: 10.1161/strokeaha.120.030601.Peer-Reviewed Original ResearchConceptsHeart rate variabilityAutonomic imbalanceHeart rateDementia riskRate variabilityStroke riskNormal intervalsCardiac autonomic imbalanceLower heart rate variabilityLower stroke riskCommunity-based cohortRisk of dementiaSuccessive differencesAutonomic nervous systemNormal RR intervalsOlder-aged adultsExam 7Incident strokeDementia pathophysiologyIncident dementiaPotential confoundersStroke occurrenceDementia incidenceThird examinationNervous system
2017
Atrial fibrillation and cognitive decline in the Framingham Heart Study
Nishtala A, Piers RJ, Himali JJ, Beiser AS, Davis-Plourde KL, Saczynski JS, McManus DD, Benjamin EJ, Au R. Atrial fibrillation and cognitive decline in the Framingham Heart Study. Heart Rhythm 2017, 15: 166-172. PMID: 28943482, PMCID: PMC5881912, DOI: 10.1016/j.hrthm.2017.09.036.Peer-Reviewed Original ResearchConceptsPrevalent atrial fibrillationVascular risk factorsAtrial fibrillationFramingham Heart StudyAF statusRisk factorsAPOE4 statusHeart StudyOffspring CohortVascular risk factor burdenCognitive performanceNP assessmentExecutive functionLongitudinal declineRisk factor burdenDomain-specific cognitive performanceApolipoprotein ε4 statusBaseline neuropsychological assessmentCross-sectional analysisInter-test intervalEligible participantsOriginal cohortVascular profilesΕ4 statusCognitive decline