2021
Autonomic Imbalance and Risk of Dementia and Stroke
Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke. Stroke 2021, 52: 2068-2076. PMID: 33874747, PMCID: PMC8154675, DOI: 10.1161/strokeaha.120.030601.Peer-Reviewed Original ResearchConceptsHeart rate variabilityAutonomic imbalanceHeart rateDementia riskRate variabilityStroke riskNormal intervalsCardiac autonomic imbalanceLower heart rate variabilityLower stroke riskCommunity-based cohortRisk of dementiaSuccessive differencesAutonomic nervous systemNormal RR intervalsOlder-aged adultsExam 7Incident strokeDementia pathophysiologyIncident dementiaPotential confoundersStroke occurrenceDementia incidenceThird examinationNervous system
2020
27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium
Wolters FJ, Chibnik LB, Waziry R, Anderson R, Berr C, Beiser A, Bis JC, Blacker D, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Davis-Plourde KL, de Wolf F, Debette S, Dufouil C, Fornage M, Goudsmit J, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Joas E, Kern S, Kuller LH, Launer L, Lopez OL, Matthews FE, McRae-McKee K, Meirelles O, Mosley TH, Pase MP, Psaty BM, Satizabal CL, Seshadri S, Skoog I, Stephan BCM, Wetterberg H, Wong MM, Zettergren A, Hofman A. 27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium. Neurology 2020, 95: 10.1212/wnl.0000000000010022. PMID: 32611641, PMCID: PMC7455342, DOI: 10.1212/wnl.0000000000010022.Peer-Reviewed Original Research
2019
Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. The Lancet Neurology 2019, 19: 61-70. PMID: 31706889, PMCID: PMC7391421, DOI: 10.1016/s1474-4422(19)30393-x.Peer-Reviewed Original ResearchConceptsBlood pressure strataAntihypertensive medicationsBlood pressureRisk of dementiaIndividual participant dataIncident dementiaAlzheimer's diseaseDementia eventsDrug classesAging Intramural Research ProgramHigh blood pressure strataProspective community-based studyStudy-specific effect estimatesParticipant dataSpecific antihypertensive medicationsAlzheimer's Drug Discovery FoundationNormal blood pressureProspective cohort studyEligible observational studiesHigh blood pressureClinical Alzheimer's diseaseBurden of diseaseCommunity-based studyFuture clinical guidelinesCommunity-dwelling adultsAssociation of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts
Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, Haan MN, Seshadri S. Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts. PLOS ONE 2019, 14: e0212293. PMID: 30768625, PMCID: PMC6377188, DOI: 10.1371/journal.pone.0212293.Peer-Reviewed Original ResearchConceptsInsulin useMRI measuresDementia/AD riskCognitive functionAssociation of metforminGlycemic control propertiesNew-onset dementiaSacramento Area Latino StudyCox regression analysisBrain MRI measuresPopulation-based cohortRisk of dementiaAdverse cognitive outcomesLife style changesGlobal cognitive functionFramingham Heart StudySulfonylurea useDiabetes medicationsReykjavik StudyGlycemic dysregulationRenal functionGlycemic controlRotterdam StudyDementia riskIncident dementia
2017
Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium
Chibnik LB, Wolters FJ, Bäckman K, Beiser A, Berr C, Bis JC, Boerwinkle E, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Debette S, Davis-Plourde KL, Dufouil C, Fornage M, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Kern S, Kuller LH, Launer L, Lopez OL, Matthews F, Meirelles O, Mosley T, Ower A, Psaty BM, Satizabal CL, Seshadri S, Skoog I, Stephan BCM, Tzourio C, Waziry R, Wong MM, Zettergren A, Hofman A. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. European Journal Of Epidemiology 2017, 32: 931-938. PMID: 29063414, PMCID: PMC5680377, DOI: 10.1007/s10654-017-0320-5.Peer-Reviewed Original ResearchConceptsIncidence of dementiaCox proportional hazards regressionPopulation-based cohortProportional hazards regressionRisk of dementiaBurden of diseaseInternational population-based cohortsRange of followPoisson regression modelsHazards regressionDementia occurrenceIncidence rateAPOE genotypeAverage ageCohortPreventive effortsDementiaUnderlying causeIncidenceCumulative hazardImpact of genderRegression modelsFollowOverweight, Obesity, and Survival After Stroke in the Framingham Heart Study
Aparicio HJ, Himali JJ, Beiser AS, Davis‐Plourde K, Vasan RS, Kase CS, Wolf PA, Seshadri S. Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study. Journal Of The American Heart Association 2017, 6: e004721. PMID: 28647687, PMCID: PMC5669145, DOI: 10.1161/jaha.116.004721.Peer-Reviewed Original ResearchConceptsIschemic strokeNormal weightStroke casesBody weightBody mass index measurementsWeight lossStable normal weightUnknown protective factorsStroke-free controlsNormal-weight participantsIschemic stroke casesCommunity-based sampleCase-control designFramingham Heart StudyCause mortalityBMI 18.5BMI categoriesHemorrhagic strokeObese participantsOverweight participantsBMI measurementsHeart StudyLower mortalityCase statusStroke