2018
Vascular risk at younger ages most strongly associates with current and future brain volume.
Pase MP, Davis-Plourde K, Himali JJ, Satizabal CL, Aparicio H, Seshadri S, Beiser AS, DeCarli C. Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology 2018, 91: e1479-e1486. PMID: 30232248, PMCID: PMC6202941, DOI: 10.1212/wnl.0000000000006360.Peer-Reviewed Original ResearchConceptsVascular risk factor burdenRisk factor burdenVascular risk factorsLower brain volumeRisk factorsStrength of associationBrain volumeYounger ageAge decadeFramingham Stroke Risk ProfileAge 45 yearsPotential therapeutic effectsStroke Risk ProfileLongitudinal analysisFramingham Heart StudyCross-sectional analysisStroke riskVascular riskDementia riskAge 45Therapeutic effectHeart StudyRisk profileBrain structuresCross-sectional data
2017
Atrial fibrillation and cognitive decline in the Framingham Heart Study
Nishtala A, Piers RJ, Himali JJ, Beiser AS, Davis-Plourde KL, Saczynski JS, McManus DD, Benjamin EJ, Au R. Atrial fibrillation and cognitive decline in the Framingham Heart Study. Heart Rhythm 2017, 15: 166-172. PMID: 28943482, PMCID: PMC5881912, DOI: 10.1016/j.hrthm.2017.09.036.Peer-Reviewed Original ResearchConceptsPrevalent atrial fibrillationVascular risk factorsAtrial fibrillationFramingham Heart StudyAF statusRisk factorsAPOE4 statusHeart StudyOffspring CohortVascular risk factor burdenCognitive performanceNP assessmentExecutive functionLongitudinal declineRisk factor burdenDomain-specific cognitive performanceApolipoprotein ε4 statusBaseline neuropsychological assessmentCross-sectional analysisInter-test intervalEligible participantsOriginal cohortVascular profilesΕ4 statusCognitive decline