2020
Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia
Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues J, Davis‐Plourde K, Debette S, Di Angelantonio E, Feart C, Frikke‐Schmidt R, Gregson J, Haan MN, Hassing LB, Hayden KM, Hoevenaar‐Blom M, Kaprio J, Kivimaki M, Lappas G, Larson EB, LeBlanc ES, Lee A, Lui L, van Charante E, Ninomiya T, Nordestgaard L, Ohara T, Ohkuma T, Palviainen T, Peres K, Peters R, Qizilbash N, Richard E, Rosengren A, Seshadri S, Shipley M, Singh‐Manoux A, Strand BH, van Gool W, Vuoksimaa E, Yaffe K, Huxley RR. Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia. Obesity Reviews 2020, 21: e12989. PMID: 31898862, PMCID: PMC7079047, DOI: 10.1111/obr.12989.Peer-Reviewed Original ResearchConceptsVascular dementia riskRisk of dementiaDementia riskWaist circumferenceWeight changeWeight lossLow-normal weightProspective cohort studyUpper normal levelBody mass indexAssociation of anthropometryCases of dementiaPercent weight changeCause dementia riskGlobal obesity epidemicNon-linear associationCohort studyCause dementiaVascular dementiaMass indexWeight maintenanceDementia subtypesPathophysiological changesClinical trialsUnderweight individuals
2019
Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. The Lancet Neurology 2019, 19: 61-70. PMID: 31706889, PMCID: PMC7391421, DOI: 10.1016/s1474-4422(19)30393-x.Peer-Reviewed Original ResearchConceptsBlood pressure strataAntihypertensive medicationsBlood pressureRisk of dementiaIndividual participant dataIncident dementiaAlzheimer's diseaseDementia eventsDrug classesAging Intramural Research ProgramHigh blood pressure strataProspective community-based studyStudy-specific effect estimatesParticipant dataSpecific antihypertensive medicationsAlzheimer's Drug Discovery FoundationNormal blood pressureProspective cohort studyEligible observational studiesHigh blood pressureClinical Alzheimer's diseaseBurden of diseaseCommunity-based studyFuture clinical guidelinesCommunity-dwelling adults