2019
Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume
Spartano NL, Davis-Plourde KL, Himali JJ, Andersson C, Pase MP, Maillard P, DeCarli C, Murabito JM, Beiser AS, Vasan RS, Seshadri S. Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume. JAMA Network Open 2019, 2: e192745. PMID: 31002329, PMCID: PMC6481600, DOI: 10.1001/jamanetworkopen.2019.2745.Peer-Reviewed Original ResearchConceptsLight-intensity physical activityTotal brain volumeHigher total brain volumeMagnetic resonance imagingPA guidelinesPhysical activityBrain volumeBrain agingVigorous PA levelsCommunity-based cohort studyPA levelsBrain magnetic resonance imagingAssociation of accelerometerCurrent PA guidelinesBrain MRI measuresFramingham Heart Study participantsVigorous physical activityAdditional hourMost older adultsFramingham Heart StudyHigher brain volumesCohort studyDementia preventionDementia riskMean age
2018
APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality
Satizabal CL, Samieri C, Davis-Plourde KL, Voetsch B, Aparicio HJ, Pase MP, Romero JR, Helmer C, Vasan RS, Kase CS, Debette S, Beiser AS, Seshadri S. APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality. Stroke 2018, 49: 2822-2829. PMID: 30571417, PMCID: PMC6310220, DOI: 10.1161/strokeaha.118.022132.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseAPOE ε4 carriersRisk of strokeHeart diseaseSD unit increaseCause strokeIschemic strokeCause mortality eventsPlasma fatty acidsFatty acidsAPOE ε4 genotypeRandom-effects modelFatty acid levelsUnit increaseMeta-analysis resultsMetabolism of lipidsLinoleic acidCause mortalityMean agePotential confoundersCardiovascular healthRisk factorsAPOE genotypeCardiovascular diseaseDietary fat