2021
Autonomic Imbalance and Risk of Dementia and Stroke
Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke. Stroke 2021, 52: 2068-2076. PMID: 33874747, PMCID: PMC8154675, DOI: 10.1161/strokeaha.120.030601.Peer-Reviewed Original ResearchConceptsHeart rate variabilityAutonomic imbalanceHeart rateDementia riskRate variabilityStroke riskNormal intervalsCardiac autonomic imbalanceLower heart rate variabilityLower stroke riskCommunity-based cohortRisk of dementiaSuccessive differencesAutonomic nervous systemNormal RR intervalsOlder-aged adultsExam 7Incident strokeDementia pathophysiologyIncident dementiaPotential confoundersStroke occurrenceDementia incidenceThird examinationNervous system
2019
Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. The Lancet Neurology 2019, 19: 61-70. PMID: 31706889, PMCID: PMC7391421, DOI: 10.1016/s1474-4422(19)30393-x.Peer-Reviewed Original ResearchConceptsBlood pressure strataAntihypertensive medicationsBlood pressureRisk of dementiaIndividual participant dataIncident dementiaAlzheimer's diseaseDementia eventsDrug classesAging Intramural Research ProgramHigh blood pressure strataProspective community-based studyStudy-specific effect estimatesParticipant dataSpecific antihypertensive medicationsAlzheimer's Drug Discovery FoundationNormal blood pressureProspective cohort studyEligible observational studiesHigh blood pressureClinical Alzheimer's diseaseBurden of diseaseCommunity-based studyFuture clinical guidelinesCommunity-dwelling adultsAssociation of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts
Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, Haan MN, Seshadri S. Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts. PLOS ONE 2019, 14: e0212293. PMID: 30768625, PMCID: PMC6377188, DOI: 10.1371/journal.pone.0212293.Peer-Reviewed Original ResearchConceptsInsulin useMRI measuresDementia/AD riskCognitive functionAssociation of metforminGlycemic control propertiesNew-onset dementiaSacramento Area Latino StudyCox regression analysisBrain MRI measuresPopulation-based cohortRisk of dementiaAdverse cognitive outcomesLife style changesGlobal cognitive functionFramingham Heart StudySulfonylurea useDiabetes medicationsReykjavik StudyGlycemic dysregulationRenal functionGlycemic controlRotterdam StudyDementia riskIncident dementia
2018
O3‐11‐01: USE OF BLOOD PRESSURE–LOWERING DRUGS AND RISK OF INCIDENT DEMENTIA AND ALZHEIMER'S DISEASE IN OLDER PEOPLE WITH AND WITHOUT HIGH BLOOD PRESSURE: A META‐ANALYSIS OF INDIVIDUAL PARTICIPANT DATA FROM PROSPECTIVE COHORT STUDIES
Ding J, Davis-Plourde K, Sedaghat S, Tully P, Wang W, Windham B, Phillips C, Griswold M, White L, Gudnason V, Debette S, Seshadri S, Ikram M, Meirelles O, Tzourio C, Launer L, Group M. O3‐11‐01: USE OF BLOOD PRESSURE–LOWERING DRUGS AND RISK OF INCIDENT DEMENTIA AND ALZHEIMER'S DISEASE IN OLDER PEOPLE WITH AND WITHOUT HIGH BLOOD PRESSURE: A META‐ANALYSIS OF INDIVIDUAL PARTICIPANT DATA FROM PROSPECTIVE COHORT STUDIES. Alzheimer's & Dementia 2018, 14: p1045-p1046. DOI: 10.1016/j.jalz.2018.06.2831.Peer-Reviewed Original Research